Comparison of the efficacy of blood and polyethylene glycol‐hemoglobin in recovery of newborn piglets from hemorrhagic hypotension: effect on blood pressure, cortical oxygen, and extracellular dopamine in the brain

Song, Dekun; Olano, Marta; Df, Wilson; Pastuszko, Anna; Tammela, Outi; Nho, Kwang; Shorr, Robert G. L.

doi:10.1046/j.1537-2995.1995.35795357876.x

Cited by 26 publications

(7 citation statements)

References 25 publications

(6 reference statements)

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“…PEG-Hb™ has been previously reported to be safe and effective in a number of animal species models [59,60,61,62]. Changes in the plasma concentration of PEG-Hb™ after a top-load infusion (25 mL/kg) was examined in rats and rabbits, and the findings showed that the mean half-life was approximately 17 h and 43 h in rats and rabbits, respectively [61,63].…”

Section: Acellular Type Hbocsmentioning

confidence: 99%

Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers

Taguchi

Yamasaki

Maruyama

et al. 2017

JFB

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Hemoglobin (Hb) is an ideal material for use in the development of an oxygen carrier in view of its innate biological properties. However, the vascular retention of free Hb is too short to permit a full therapeutic effect because Hb is rapidly cleared from the kidney via glomerular filtration or from the liver via the haptogloblin-CD 163 pathway when free Hb is administered in the blood circulation. Attempts have been made to develop alternate acellular and cellular types of Hb based oxygen carriers (HBOCs), in which Hb is processed via various routes in order to regulate its pharmacokinetic properties. These HBOCs have been demonstrated to have superior pharmacokinetic properties including a longer half-life than the Hb molecule in preclinical and clinical trials. The present review summarizes and compares the pharmacokinetic properties of acellular and cellular type HBOCs that have been developed through different approaches, such as polymerization, PEGylation, cross-linking, and encapsulation.

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Section: Acellular Type Hbocsmentioning

confidence: 99%

Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers

Taguchi

Yamasaki

Maruyama

et al. 2017

JFB

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“…PEG‐Hb, with its high colloidal osmotic pressure and long circulating half‐life, is exemplary for plasma expansion. In addition, PEG‐Hb has been shown preclinically to readily deliver oxygen to major organs and tissues including brain, muscle, liver, kidney and spleen (16,17). In fact, evidence of tissue oxygenation with PEG‐Hb resuscitation following hemorrhagic insult has been documented (16,18,19).…”

mentioning

confidence: 99%

PEG‐Hemoglobin as a Resuscitation Solution in the Treatment of Hypovolemic Shock in the Anesthetized Rat

et al. 1999

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This study was designed to determine the advantages of using the hemoglobin-based oxygen carrier, polyethylene glycol conjugated bovine hemoglobin (PEG-Hb), as an additive to Ringer's lactate solution (RLS) for the treatment of acute hemorrhage in anesthetized female rats. Different compositions of PEG-Hb and RLS were administered intravenously in a paradigm that provided 30 ml/kg of resuscitation fluid following an episode of 15 min of hypotension. Hypotension was achieved by the removal of blood (1 ml/min) from the femoral vein until the mean arterial pressure was lowered to or below 50 mmHg and subsequently maintained until resuscitation. Short-term cardiovascular assessment showed that resuscitation fluids containing PEG-Hb resulted in higher mean arterial pressure, aortic blood flow, renal blood flow, and less dramatic shifts in arterial base excess and respiratory blood gases than plain RLS. The long-term survival experiment showed lower lactate dehydrogenase, alkaline phosphatase, and serum glutamic pyruvic transaminase levels in most groups resuscitated with solutions containing PEG-Hb, but no differences in survival (100%) were observed. The data suggest that the addition of PEG-Hb to RLS improves its resuscitative effects. Specifically, a solution of 50% RLS:50% PEG-Hb appeared to have the most favorable cardiovascular and metabolic effects in this anesthetized rat hypovolemic shock resuscitation model. Presumably, the improved effects seen with the addition of PEG-Hb were due to its innate plasma expansion and oxygen-delivery capabilities.

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“…This change in the design strategy came from the observation that DecaPEGylated bovine Hb of Enzon is unique and distinct from other derivatives of Hb designed so far as HBOC in that it is a conjugated protein and exhibits plasma expander like properties (Shorr et al 1999, Song et al 1995). A new PEG conjugated Hb, EAF P5K6 Hb, was designed and developed at Einstein using the new Extension Arm Chemistry based PEGylation platform.…”

Section: Discussionmentioning

confidence: 99%

PEGylation of αα-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG αα-Hbs

Meng

Tsai²,

Intaglietta³

et al. 2014

Artificial Cells, Nanomedicine, and Biotechnology

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PEGylation of intramolecularly crosslinked Hb has been studied here to overcome the limitation of dissociation of Hb tetramers. New hexa and deca PEGylated low oxygen affi nity PEG-αα-Hbs have been generated. Infl uence of PEG conjugation chemistry and the PEG shell structure on the functional properties as well as PEGylation induced plasma expander like properties of the protein has been delineated. The results have established that in the design of PEG-Hbs as oxygen therapeutics, the infl uence of conjugation chemistry and the PEG shell structure on the oxygen affi nity of Hb needs to be optimized independently besides optimizing the PEG shell structure for inducing resuscitation fluid like properties.

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Comparison of the efficacy of blood and polyethylene glycol‐hemoglobin in recovery of newborn piglets from hemorrhagic hypotension: effect on blood pressure, cortical oxygen, and extracellular dopamine in the brain

Cited by 26 publications

References 25 publications

Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers

Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers

PEG‐Hemoglobin as a Resuscitation Solution in the Treatment of Hypovolemic Shock in the Anesthetized Rat

PEGylation of αα-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG αα-Hbs

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