Effect of Helicobacter pylori Eradication on Insulin Resistance, Serum Lipids and Low-Grade Inflammation

Gen, Ramazan; Demir, Mehmet Emin; Ataseven, Hilmi

doi:10.1097/smj.0b013e3181cf373f

Cited by 114 publications

(115 citation statements)

References 33 publications

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“…It has also been reported that H.pylori infection plays a role in the regulation of leptin and ghrelin (Francois et al, 2011), two hormones involved in energy homeostasis where their interaction affects obesity, insulin sensitivity and glucose homeostasis (Sun et al, 2006;Williams and Mobarhan, 2003). Furthermore, H.pylori eradication seems to have beneficial effects on insulin resistance, lipid abnormalities and low-grade inflammation (Gen et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Cardaropoli

Giuffrida

Piazzese

et al. 2015

Journal of Reproductive Immunology

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Cardaropoli

Giuffrida

Piazzese

et al. 2015

Journal of Reproductive Immunology

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“…The Maastricht IV consensus report declares that H. pylori eradication does not cause or worsen obesity and related illnesses 9. Recent studies showed the relationship between H. pylori and insulin resistance or diabetes 10. Accordingly, a favorable effect of H. pylori eradication on insulin resistance was also documented in some studies 11 . However, this relationship is not well defined yet due to some pitfalls in those studies 12 .…”

Section: Introductionmentioning

confidence: 99%

The effect of Helicobacter pylori eradication on insulin resistance and HbA1c level in people with normal glucose levels: a prospective study

Doğan¹,

Sarıkaya²,

Ergül³

et al. 2015

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background and Aim. Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrome. These conditions are attributed to systemic inflammation, leptin or ghrelin changes due to H. pylori infection. Therefore, increasing trends in the management of H. pylori infection are ordered to maintain glycemic control. In this study, we evaluated the effect of H. pylori eradication on insulin resistance in patients with normal blood glucose concentrations. Method. A total of 370 patients with successful eradication were included in the study. Patients with H. pylori were given triple eradication treatment. All patients with H. pylori infection were tested for fasting glucose, fasting insulin, glicated hemoglobin (HbA1c) at baseline and 6 months after eradication treatment. Also, insulin resistance was calculated using the homeostatic model assessment of insulin resistance (HOMA-IR). Body mass index was also determined as a metabolic syndrome criteria effecting insulin resistance.Results. There were significant differences in fasting glucose, fasting insulin, HbA1c, and HOMA-IR values between before treatment and after treatment(P <0.04, <0.01, <0.01, <0.01). The favorable effect of eradication was more significant in patients with BMI≥25 mg/m²(P<0.05). Conclusion. Eradication treatment has beneficial effects on insulin resistance in patients with normal glucose concentrations.

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“…Other studies show that six weeks after the end of eradication therapy, the mean fasting insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR), triglycerides (TG), light density lipoprotein C (LDL-C), and C-reactive peptide (CRP) levels in patients with successful eradication were significantly decreased from the pretreatment levels and high density lipoprotein C (HDL-C) level was significantly increased from the pretreatment levels. The mean fasting insulin, HOMA-IR, total cholesterol (TC), TG, LDL-C, CRP levels and HDL-C levels in patients with unsuccessful eradication were not significantly changed from pretreatment levels [20]. Other studies also showed positive lipid profile changes and inflammatory marker decrease [21].…”

Section: Metabolic Changes In Hp With T2dmmentioning

confidence: 70%

Untitled

2016

Russ. Open Med. J.

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Abstract:The incidence and prevalence of type 2 diabetes mellitus is considered to be one of the most critical problems in the healthcare system. The pathophysiology of the disease has proven to be complicated and multiple factors are involved in its development. Recently Helicobacter pylori was proposed as a new risk factor for developing type 2 diabetes mellitus as well as other disease. This study is a review of the current data involving Helicobacter pylori association with type 2 diabetes mellitus and its complications.

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Effect of Helicobacter pylori Eradication on Insulin Resistance, Serum Lipids and Low-Grade Inflammation

Abstract: This study showed beneficial effects of HP eradication on insulin resistance, atherogenic lipid abnormalities and low-grade inflammation. The results suggest that HP eradication may prevent coronary artery disease and metabolic syndrome.

Cited by 114 publications

References 33 publications

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

Helicobacter pylori seropositivity and pregnancy-related diseases: a prospective cohort study

The effect of Helicobacter pylori eradication on insulin resistance and HbA1c level in people with normal glucose levels: a prospective study

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