The effect of Helicobacter pylori eradication on insulin resistance and HbA1c level in people with normal glucose levels: a prospective study

Abstract

Background and Aim. Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrome. These conditions are attributed to systemic inflammation, leptin or ghrelin changes due to H. pylori infection. Therefore, increasing trends in the management of H. pylori infection are ordered to maintain glycemic control. In this study, we evaluated the effect of H. pylori eradication on insulin resistance in patients with normal blood glucose concentrations. Method. A total of 370 patients with successful eradication were included in the study. Patients with H. pylori were given triple eradication treatment. All patients with H. pylori infection were tested for fasting glucose, fasting insulin, glicated hemoglobin (HbA1c) at baseline and 6 months after eradication treatment. Also, insulin resistance was calculated using the homeostatic model assessment of insulin resistance (HOMA-IR). Body mass index was also determined as a metabolic syndrome criteria effecting insulin resistance.Results. There were significant differences in fasting glucose, fasting insulin, HbA1c, and HOMA-IR values between before treatment and after treatment(P <0.04, <0.01, <0.01, <0.01). The favorable effect of eradication was more significant in patients with BMI≥25 mg/m²(P<0.05). Conclusion. Eradication treatment has beneficial effects on insulin resistance in patients with normal glucose concentrations.

Effect of Helicobacter pylori eradication on insulin resistance among prediabetic patients: A pilot study and single-blind randomized controlled clinical trial

“…Also, significant difference of FPI and HOMA-B (as an insulin secretion index) between the treatment group and placebo group confirmed increasing insulin resistance of the treatment group. In fact, in contrast to other studies,[232429303132333435] HP eradication with antibiotics did not improve insulin resistance but increased it.…”

“…There are several studies, which confirmed the relationship between HP infection and insulin resistance. [232429303132333435] Among them, some researches specifically studied the effect of HP eradication on insulin resistance. In a study by Dogan et al .,[30] 370 patients with HP infection were chosen and treated for HP.…”

“…In some studies, the effect of HP eradication was explored among healthy individuals[293036] and the effectiveness of medication on insulin resistance was concluded. However, in this study prediabetic patients were chosen.…”

The Possible Role of Helicobacter pylori Infection in Non-alcoholic Fatty Liver Disease

“…Many other studies also demonstrated the causal relationship between H. pylori and IR (Polyzos et al, 2013b; Chen et al, 2015). A prospective study reported that after H. pylori eradication, the fasting plasma insulin level ( p < 0.01) and HOMA-IR ( p < 0.01) were significantly lower than before treatment, indicating that H. pylori eradication improved IR and may prevent the occurrence of MS, and NAFLD (Abenavoli et al, 2013; Dogan et al, 2015). …”

“…We all know that H. pylori infection is one of the most important environmental risk factors for the diseases of chronic gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. Recently, accumulating evidence implicates H. pylori infection existing in the patients with extragastrointestinal diseases, including idiopathic thrombocytopenic purpura, ischemic heart diseases, obesity, type 2 diabetes mellitus (T2DM) (Wong et al, 2014; Dogan et al, 2015; Nasif et al, 2016). In addition, there is a special focus on the relationship between H. pylori infection and NAFLD.…”