Effect of Helicobacter pylori eradication in the treatment of Japanese patients with chronic idiopathic urticaria

Fukuda, Shinsaku; Shimoyama, Tadashi; Umegaki, Noriko; Mikami, Taisei; Nakano, Hajime; Munakata, Akihiro

doi:10.1007/s00535-004-1397-7

Cited by 64 publications

(58 citation statements)

References 18 publications

(23 reference statements)

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“…Serum IgG levels for HP were measured by a commercially available direct ELISA kit ("E Plate 'Eiken' HP Antibody" Eiken Kagaku). This ELISA kit was developed in Japan by using the antigen extracted from a domestic strain in Japan and is commonly used in medical studies (26,27). Positivity for HP infection was defined as an anti-HP IgG antibody level greater than 10 U/mL in serum.…”

Section: Ag and Hp Infection Assessmentmentioning

confidence: 99%

ABO Genotype and the Risk of Gastric Cancer, Atrophic Gastritis, and Helicobacter pylori Infection

Nakao

Matsuo

Ito

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Although several studies have investigated the association between ABO blood type and risk of gastric cancer (GC), atrophic gastritis (AG), and Helicobacter pylori (HP) infection, no study has investigated these associations by using ABO genotype.Methods: We conducted a case-control study in 703 patients with GC and 1,465 noncancer patients. We also conducted a cross-sectional study by using 1,406 of these 1,465 controls, who were examined for pepsinogens and anti-HP IgG antibody levels in serum. ABO genotype was determined from single nucleotide polymorphisms in ABO gene. We used rs8176719 to mark the O allele, and rs8176746 and rs8176747 to mark the B allele. ORs and 95% CIs were calculated by a multivariate logistic model.Results: We observed significant associations between ABO genotype and GC, AG, and HP infection. ORs (95% CIs) of GC were 0.70 (0.50-0.99) for OO and 0.53 (0.36-0.77) for BO relative to AA genotype. An increased risk of GC was observed with addition of the A allele (P trend < 0.001), and a decreased risk with that of the B allele (P trend ¼ 0.023). An OR of AG was 0.73 (95% CI, 0.53-0.99) for blood type B relative to blood type A, and an OR of HP infection was 0.39 (95% CI, 0.17-0.87) for BB relative to AA genotype.Conclusion: This study identified a statistically significant association between ABO genotype and GC risk. In addition, ABO gene locus may influence AG prevalence and HP infection.Impact: Further studies are necessary to confirm these findings. Cancer Epidemiol Biomarkers Prev; 20(8); 1665-72. Ó2011 AACR.

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Section: Ag and Hp Infection Assessmentmentioning

confidence: 99%

ABO Genotype and the Risk of Gastric Cancer, Atrophic Gastritis, and Helicobacter pylori Infection

Nakao

Matsuo

Ito

et al. 2011

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…This ELISA kit was developed in Japan using the antigen extracted from the domestic strain of HP in Japan and is commonly used in medical studies. (19,20) Positivity for HP infection was defined as an anti-HP IgG antibody level >10 U ⁄ mL in serum.…”

Section: Methodsmentioning

confidence: 99%

Association between insulin‐like growth factor‐1 polymorphisms and stomach cancer risk in a Japanese population

Ennishi

Shitara²,

Ito

et al. 2011

Cancer Science

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The insulin-like growth factor (IGF) signaling system plays a central role in cellular growth, differentiation and proliferation. Although the association between IGF1 gene polymorphisms and cancer risk has been evaluated for several carcinomas, this association has not yet been examined for stomach cancer. We investigated the association between IGF1 polymorphisms and the risk of stomach cancer in a Japanese population. A total of 703 patients with stomach cancer and 1462 non-cancer control subjects were enrolled in this case-control study. Associations between polymorphisms of 10 IGF1 loci and the risk of stomach cancer were evaluated using odds ratios (OR) and 95% confidence intervals (CI) in multiple logistic regression models. We observed that the C allele in rs1520220 and the G allele in rs4764887 were significantly associated with stomach cancer risk in the per-allele model after adjusting for other risk factors (OR: 1.14 [95% CI: 1.00-1.30] and OR: 1.18 [95% CI: 1.02-1.36], respectively). We also observed a positive and dosedependent association between the number of risk alleles and stomach cancer risk (P-trend: 0.019) when examining the two loci in the same model. These associations were still seen after adjusting for potential confounders, including sex, age, smoking status, history of diabetes and family history of stomach cancer. We did not find any significant interaction between these factors and the number of risk alleles. In conclusion, we observed a significant association between IGF1 polymorphisms and stomach cancer risk among a Japanese population. Examination of the biological significance of IGF1 is warranted. (Cancer Sci 2011; 102: 2231-2235 S tomach cancer remains one of the most common cancers in Japan, as well as worldwide.(1) The known and suspected risk factors for stomach cancer include smoking, diabetes, family history of stomach cancer, green tea intake and Helicobacter pylori infection. Recent studies have focused on the detection of single nucleotide polymorphisms (SNP) that have an incident and prognostic impact in cancer, including stomach cancer. Specifically, SNP in the gene encoding insulin-like growth factor (IGF) have been studied in the context of several cancers, but to our knowledge, their influence in the development of stomach cancer has not yet been investigated.The IGF signaling system plays a central role in cellular growth, differentiation and proliferation.(2) IGF1 is reported to be a potential proliferative molecule, affecting almost every cell type via the RAS-mitogen-activated protein kinase signaling pathway. (3,4) It is also reported to be a powerful antiapoptotic molecule, activating the phosphatidylinositol-3 kinase-AKT pathway, which ultimately activates downstream transcription factors that regulate gene expression of proliferative, differentiation and antiapoptotic factors.(3,4) Given this role of IGF1 in stimulating cellular growth and inhibiting apoptosis, abnormalities in IGF1 levels might contribute to the development of cancer. IGF1 polymorphisms ...

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“…Another suggestion is that Hp-associated lipoprotein 20 (lpp20) could act as an antigen that is involved in molecular mimicry to mast cells, T cells, and B cells as well [51][52][53]. Also in some studies, eradication of Hp infection resulted in remission of CSU symptoms [54,55].…”

Section: Comorbidities and Possible Triggering Factorsmentioning

confidence: 99%

Comorbidities in Chronic Spontaneous Urticaria

Gönül¹,

Ayvaz²,

Kartal³

2017

A Comprehensive Review of Urticaria and Angioedema

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Chronic spontaneous urticaria (CSU) is a disease that makes people's lives miserable with unknown etiology. In recent years, there have been many studies trying to explain the etiology of CSU, and many of them reported that there are some comorbidities or triggering factors related to CSU. However, it has not been clearly known yet that whether these conditions are true comorbidities associated with CSU or they are coincidentally found at the same time. In this chapter, related comorbidities and conditions have been told.

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Effect of Helicobacter pylori eradication in the treatment of Japanese patients with chronic idiopathic urticaria

Abstract: Eradication of H. pylori would be a valid choice for patients with CIU, although the prevalence of H. pylori infection is not higher in patients with CIU than it is in controls.

Cited by 64 publications

References 18 publications

ABO Genotype and the Risk of Gastric Cancer, Atrophic Gastritis, and Helicobacter pylori Infection

ABO Genotype and the Risk of Gastric Cancer, Atrophic Gastritis, and Helicobacter pylori Infection

Association between insulin‐like growth factor‐1 polymorphisms and stomach cancer risk in a Japanese population

Comorbidities in Chronic Spontaneous Urticaria

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