Association between insulin‐like growth factor‐1 polymorphisms and stomach cancer risk in a Japanese population

Ennishi, Daisuke; Shitara, Kohei; Ito, Hidemi; Hosono, Satoyo; Watanabe, Miki; Ito, Seiji; Sawaki, Akira; Yatabe, Yasushi; Yamao, Kenji; Tajima, Kazuo; Tanimoto, Mitsune; Tanaka, Hideo; Hamajima, Nobuyuki; Matsuo, Keitaro

doi:10.1111/j.1349-7006.2011.02062.x

Cited by 20 publications

(15 citation statements)

References 23 publications

(38 reference statements)

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“…It is found that the IGF signaling pathway plays an important role in some cancers. 15,16 IGF1 rs5742612 A > G polymorphism was found to be associated with tumor response to chemotherapy in patients with advanced gastric cancer. Dietary interventions and modifications may downregulate IGF1 activity and reduce the susceptibility of cancer by promoting increased glucagon activity.…”

Section: Introductionmentioning

confidence: 98%

Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk

Tang

Chen

Liu

et al. 2018

J of Cellular Biochemistry

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Esophagogastric junction adenocarcinoma (EGJA) may be associated with obesity and overweight. Thus, any variant in energy metabolism–related gene may influence the development of EGJA. In this study, we recruited 720 EGJA cases and 1541 noncancer controls. We selected IGF2BP2 rs4402960 G > T, rs1470579 A > C, IGF1 rs5742612 A > G and IGFBP3 rs3110697 G > A, rs2270628 C > T and rs6953668 G > A loci and assessed the relationship of these polymorphisms with lymph node status and susceptibility of EGJA. We found that IGF2BP2 rs1470579 A > C and IGFBP3 rs6953668 G > A polymorphisms were associated with the decreased risk of EGJA ( IGF2BP2 rs1470579: CC vs AA: adjusted odds ratio [OR] = 0.65, 95% confidence interval [CI] = 0.43‐0.98, P = 0.041 and CC vs AA/AC: adjusted OR = 0.62, 95% CI = 0.41‐0.93, P = 0.021 and IGFBP3 rs6953668: GA vs GG: adjusted OR = 0.66, 95% CI = 0.47‐0.93, P = 0.019 and GA/AA vs GG: adjusted OR = 0.68, 95% CI = 0.48‐0.95, P = 0.026). However, we also found that IGF1 rs5742612 A > G polymorphism increased the risk of LNM among patients with EGJA (GG vs AA: adjusted OR = 1.88, 95% CI = 1.02‐3.46, P = 0.042 and GG vs AA/AG: adjusted OR = 1.92, 95% CI = 1.06‐3.47, P = 0.032). This study suggests that IGF2BP2 rs1470579 A > C and IGFBP3 rs6953668 G > A polymorphisms may decrease genetic susceptibility to EGJA in eastern Chinese Han population. In addition, our findings also indicate that IGF1 rs5742612 A > G polymorphism may increase the susceptibility of LNM among patients with EGJA.

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Section: Introductionmentioning

confidence: 98%

Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk

Tang

Chen

Liu

et al. 2018

J of Cellular Biochemistry

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“…Genetic factors could influence circulating IGF1 concentration [24]. Nowadays, multiple studies in many places have reported the associations between IGF1 polymorphisms and various cancers [25,26,27,28,29,30,31]. However, there have been no studies to investigate the IGF1 polymorphism and risk of childhood ALL.…”

Section: Introductionmentioning

confidence: 99%

Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children

Lu¹,

Wang²,

He³

et al. 2015

Cell Physiol Biochem

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Background/Aims: IGF1 is a key regulator in cell proliferation and apoptosis, and the 3' un-translated region (3'UTR) of the gene plays an important role in gene expression. For the first time, we explored the relationship between polymorphisms in the IGF1 3'UTR region and the risk of childhood acute lymphoblastic leukemia (ALL). Methods: Questionnaires were applied to collect epidemiological data. The genotypes of IGF1 polymorphisms were tested in a population of 744 ALL patients and 1088 cancer-free controls utilizing Taqman. Cell functional studies included real-time PCR, cell culture and transfection and luciferase assays. Results: We found that rs6214 homozygous AA genotype and rs6218 homozygous CC genotype were significantly associated with increased risk of childhood ALL. In addition, rs6218 CC genotype was associated with increased level of IGF1 mRNA in bone marrow, and the mutation in rs6218 led to aberrant binding capacity of hsa-miR-603 and hsa-miR-3941 in the 3'UTR of IGF1. Conclusion: Polymorphisms of rs6214 and rs6218 in the 3'UTR of IGF1 are associated with childhood ALL susceptibility, and the polymorphism of rs6218 is related with IGF1 expression at mRNA level.

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“…The C allele of rs1520220 was found significantly associated with increased serum IGF1 levels and an increased risk of breast cancer in women [68]. Later, the rs1520220 C allele was widely discussed in increasing different types of cancer risks and IGF1 serum levels, such as prostate cancer [69,70], ovarian cancer [71], stomach cancer [72], and more. Of these studies, none have been addressed in melanoma, and hence, the actual causal mechanism of IGF1 rs1520220 in melanoma remains unclear.…”

Section: Discussionmentioning

confidence: 99%

A Possible Link of Genetic Variations in ER/IGF1R Pathway and Risk of Melanoma

Yuan

Yourk

Farhat

et al. 2020

IJMS

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The mechanism of gender disparity in cutaneous melanoma incidence remains unclear. Steroid hormones including estrogens have long been implicated in the course of melanoma, but the conclusion is controversial. Estrogen receptors (ERs) and insulin-like growth factor 1 receptor (IGF1R) show extensive crosstalk in cancer development, but how the ER/IGF1R network impacts melanoma is currently unclear. Here we studied the melanoma associations of selected SNPs from the ER/IGF1R network. Part of the International Genes, Environment, and Melanoma (GEM) cohort was used as a discovery set, and the Gene Environment Association Studies Initiative (GENEVA) dataset served as a validation set. Based on the associations with other malignant disease conditions, thirteen single nucleotide polymorphism (SNP) variants in ESR1, ESR2, IGF1, and IGF1R were selected for candidate gene association analyses. The rs1520220 in IGF1 and rs2229765 in IGF1R variants were significantly associated with melanoma risk in the GEM dataset after Benjamini-Hochberg multiple comparison correction, although they were not validated in the GENEVA set. The discrepancy may be caused by the multiple melanoma characteristics in the GEM patients. Further analysis of gender disparity was carried out for IGF1 and IGF1R SNPs in the GEM dataset. The GG phenotype in IGF1 rs1520220 (recessive model) presented an increased risk of melanoma (OR = 8.11, 95% CI: 2.20, 52.5, p = 0.006) in men but a significant opposite effect in women (OR = 0.15, 95% CI: 0.018, 0.86, p = 0.045). The AA genotype in IGF1R rs2229765 (recessive model) showed a significant protective effect in men (OR = 0.24, 95% CI: 0.07, 0.64, p = 0.008) and no effect in women. Results from the current study are warranted for further validation.

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Association between insulin‐like growth factor‐1 polymorphisms and stomach cancer risk in a Japanese population

Cited by 20 publications

References 23 publications

Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk

Investigation of IGF1, IGF2BP2, and IGFBP3 variants with lymph node status and esophagogastric junction adenocarcinoma risk

Interaction Between IGF1 Polymorphisms and the Risk of Acute Lymphoblastic Leukemia in Chinese Children

A Possible Link of Genetic Variations in ER/IGF1R Pathway and Risk of Melanoma

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