Effect of Heavy Metals on Tyrosine Kinases Signaling during Sperm Capacitation

Kushwaha, Bhawna; Beniwal, Rohit; Mohanty, Aradhana; Singh, Ajay Kumar; Yadav, Raj Kumar; Garg, Satish K.

doi:10.5772/intechopen.99261

Cited by 3 publications

(1 citation statement)

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“…The cellular pathways relating to Ca ++ control sperm motility and act as an indirect measure for sperm mitochondrial function. Pb, being a divalent metal, can mimic Ca ++ entry and its functions, thereby affecting the sperm capacitation process by inhibiting or inducing tyrosine phosphorylation (Kushwaha et al, 2021). The reduction in sperm quality observed in this study may be due to Pb exposure, which is thought to generate ROS in sperm cells, and an increase in ROS can decrease sperm membrane fluidity (Barbier et al, 2010).…”

Section: Discussionmentioning

confidence: 71%

Cytotoxic effects of heavy metals on functional attributes of boar sperm: an in vitro study

Kadirvel,

Diengdoh,

Deori

et al. 2023

Front. Environ. Sci.

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Objective: Reproductive toxicology is a field that deals with the effects of heavy metals on various aspects of reproduction, including sperm count, motility, viability, spermatogenesis, follicular atresia, hormonal imbalance, and oocyte maturation, among others. The present study was carried out to examine the effects of heavy metals, viz., arsenic (As), lead (Pb), and fluoride (F), on boar sperm quality parameters in vitro.Materials and Methods: Forty (40) ejaculates from six (6) boars, averaging eight ejaculates per boar, were collected with the gloved hand technique using a dummy sow. Six (6) different concentrations were selected for the in vitro study: 5, 10, 25, 50, 100, and 200 µM for As and Pb, and 5, 10, 25, 50, 100, and 200 mM for F. The ejaculates were co-incubated with heavy metals at these different concentrations and assessed after different incubation periods (0, 0.5, and 1 h) for sperm functional attributes, viz., sperm progressive motility, viability and membrane integrity, and sperm mitochondrial membrane potential (MMP). The combined effects of heavy metals on sperm functional attributes were also evaluated at different doses (5, 10, 25, 50, 100, and 200 μM/μM for As–Pb; 5, 10, 25, 50, 100, and 200 μM/mM for As–F; and 5, 10, 25, 50, 100, and 200 μM/mM for Pb–F).Results: The present study revealed a highly significant (p <0.001) decrease in sperm progressive motility, viable sperm, membrane integrity, and sperm MMP in samples treated with heavy metals under different incubation periods; furthermore, the longer the incubation time, the greater the toxicity. There was also a significant (p <0.05) decrease in sperm motility, membrane integrity, and MMP in the samples treated with combined heavy metals (As–Pb, As–F, and Pb–F), as compared to the control, after different incubation periods. A significant (p <0.05) reduction in sperm quality attributes was recorded even at the lowest concentrations in the case of heavy metal combinations.Conclusion: It can be concluded that As, Pb, and F are toxic to boar spermatozoa in vitro, causing reductions in sperm functional attributes in a dose- and time-dependent manner.

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Section: Discussionmentioning

confidence: 71%

Cytotoxic effects of heavy metals on functional attributes of boar sperm: an in vitro study

Kadirvel,

Diengdoh,

Deori

et al. 2023

Front. Environ. Sci.

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Assessing the impact and mechanisms of environmental pollutants (heavy metals and pesticides) on the male reproductive system: a comprehensive review

Gautam,

Priyadarshini,

Patel

et al. 2024

Journal of Environmental Science and Health, Part C

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Recent Research Advances on Heavy Metals, Microplastics, Persistent Organic Pollutants, and Solid Waste in Aquatic and Terrestrial Ecosystems

Zhang,

Xu,

Guo

et al. 2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Effect of Heavy Metals on Tyrosine Kinases Signaling during Sperm Capacitation

Cited by 3 publications

References 141 publications

Cytotoxic effects of heavy metals on functional attributes of boar sperm: an in vitro study

Cytotoxic effects of heavy metals on functional attributes of boar sperm: an in vitro study

Assessing the impact and mechanisms of environmental pollutants (heavy metals and pesticides) on the male reproductive system: a comprehensive review

Recent Research Advances on Heavy Metals, Microplastics, Persistent Organic Pollutants, and Solid Waste in Aquatic and Terrestrial Ecosystems

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