Effect of heavy metals in the meconium on preterm mortality: Preliminary study

Turker, Gülcan; Özsoy, Gamze; Özdemir, Semra; Barutçu, Bora; Gökalp, Ayşe Sevim

doi:10.1111/j.1442-200x.2012.03744.x

Cited by 13 publications

(7 citation statements)

References 24 publications

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“…In this study, the profiling of detected heavy metal residues in meconium suggested that the participants might commonly expose to these metals (Table 2). Compared to other reports, the extent of exposure may be area specific (Table 4), e.g., Pb, Hg and Cd exposure in inhabitants from heavily contaminated regions and/or industrialized metropolis [34-36] is noticeably higher than those from remote and/or rural areas [14,37,38]. Selected metals detected in our studied subjects may have similar sources, which could be mainly related to contaminated dietary items [39-41] and dust ingestion [42], as a consequence of rapid industrialization and increasing environmental pollution throughout China.…”

Section: Discussionmentioning

confidence: 83%

A nested case-control study indicating heavy metal residues in meconium associate with maternal gestational diabetes mellitus risk

et al. 2015

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BackgroundEnvironmental pollutant exposure may play certain roles in the pathogenesis and progression of diabetes mellitus including gestational diabetes mellitus (GDM). We hypothesize that heavy metal exposure may trigger GDM during pregnancy. The objective of this study was to investigate the possible associations between selected heavy metal exposure and GDM risk.MethodsThis investigation is a retrospective case–control study nested within a cohort of 1359 pregnant women. These participants were recruited in Xiamen Maternity and Child Care Hospital, China, during June to July, 2012. All their newborns’ meconium samples were collected. By reviewing the antenatal care records, 166 GDM mothers were screened out from the 1359 participants; 137 of 166 GDM mothers offered their newborns’ meconium samples for the metal analysis. Those 137 mothers were set as the case group. Similarly, 294 healthy mothers without any gestational complication were initially screened out from the rest 1193 non-GDM mothers. 190 of the 294 healthy mothers offered their newborns’ meconium samples for the metal analysis. Those 190 mothers were set as the control group. Arsenic (As), mercury (Hg), lead (Pb), cadmium (Cd), and chromium (Cr) levels in these case–control meconium samples were measured by inductively coupled plasma mass spectrometry. The possible association between the metal levels and maternal GDM risk of studied subjects was assessed by binary logistic regression.ResultsGDM prevalence of 12.21% was observed in the investigated 1359 participants. The concentrations of As, Hg, Cr and Cd in studied cases were significantly higher (p < 0.05) than those of controls. After adjustments for maternal age, pre-pregnant body mass index, gravidity, parity, hepatitis B virus infection, and newborn sex, As, Cd and Cr were found to be positively associated with GDM prevalence in dose-dependent manners. Among them, As was detected in all samples and its levels associated the maternal GDM with the adjusted odds ratios of 3.28 [95% CI 1.24, 8.71], 3.35 [95% CI 1.28, 8.75] and 5.25 [95% CI 1.99, 13.86] for the 2nd, 3rd and 4th quartiles, respectively.ConclusionsThe present work implies that exposure to some of the selected metals (noticeably As) may contribute to maternal GDM risk during pregnancy.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-015-0004-0) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 83%

A nested case-control study indicating heavy metal residues in meconium associate with maternal gestational diabetes mellitus risk

et al. 2015

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“…The reason is that the concentrations of toxic metals and trace elements in a newborn's blood mostly depend on the instantaneous status of circulation and metabolism. 27,28 Meconium is the dark viscous stool that is passed by newborns in the first few days of life. This material may provide an index of mineral accumulation by the fetus, as stool is normally not excreted during intrauterine life.…”

Section: Cadmium Iron Zinc Coppermentioning

confidence: 99%

Do toxic metals and trace elements have a role in the pathogenesis of conotruncal heart malformations?

et al. 2016

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“…However, the potential of remote sensing in conjunction with GIS largely remains largely underutilized in local mortality surveillance. Few studies incorporating geospatial tools to evaluate all the causes of death of a study area have been reported [ 27 , 28 ]. In our current study, we investigated the land use changes of Suxian District from 1985 to 2012, and explored the association between the disease mortality risk and distance to the Suxian District mining industries area.…”

Section: Introductionmentioning

confidence: 99%

Study on Association between Spatial Distribution of Metal Mines and Disease Mortality: A Case Study in Suxian District, South China

Song

Jiang

Wang

et al. 2013

IJERPH

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Metal mines release toxic substances into the environment and can therefore negatively impact the health of residents in nearby regions. This paper sought to investigate whether there was excess disease mortality in populations in the vicinity of the mining area in Suxian District, South China. The spatial distribution of metal mining and related activities from 1985 to 2012, which was derived from remote sensing imagery, was overlapped with disease mortality data. Three hotspot areas with high disease mortality were identified around the Shizhuyuan mine sites, i.e., the Dengjiatang metal smelting sites, and the Xianxichong mine sites. Disease mortality decreased with the distance to the mining and smelting areas. Population exposure to pollution was estimated on the basis of distance from town of residence to pollution source. The risk of dying according to disease mortality rates was analyzed within 7–25 km buffers. The results suggested that there was a close relationship between the risk of disease mortality and proximity to the Suxian District mining industries. These associations were dependent on the type and scale of mining activities, the area influenced by mining and so on.

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Effect of heavy metals in the meconium on preterm mortality: Preliminary study

Abstract: Meconium lead level and gestational age are associated with increased mortality risk in preterm neonates.

Cited by 13 publications

References 24 publications

A nested case-control study indicating heavy metal residues in meconium associate with maternal gestational diabetes mellitus risk

A nested case-control study indicating heavy metal residues in meconium associate with maternal gestational diabetes mellitus risk

Do toxic metals and trace elements have a role in the pathogenesis of conotruncal heart malformations?

Study on Association between Spatial Distribution of Metal Mines and Disease Mortality: A Case Study in Suxian District, South China

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