Effect of Heat Shock Preconditioning on Pressure Injury Prevention via Hsp27 Upregulation in Rat Models

Xu, Huiwen; Takashi, En; Liang, Jingyan; Chen, Yajie; Yuan, Yuan; Fan, Jianglin

doi:10.3390/ijms23168955

Cited by 3 publications

(3 citation statements)

References 52 publications

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“…Various combinations of effects are known, for example, when a chemical effect is manifested by a physical one or vice versa. The preconditioning effect is known at the level of the organism [88,89], physiology [90,91], tissues [8,92], cells [93], and biological residues, liquids, aqueous colloids, and solutions [94,95], and, as shown in this study, in water.…”

Section: Influence Of Magnetic Field and Mechanical Action By Pipetti...mentioning

confidence: 88%

Possible Approaches to Studying the Influence of Magnetic Fields and Mechanical Effects on the Physicochemical Properties of Aqueous IgG Colloids

Nagaev,

Molkova,

Pustovoy

et al. 2023

Applied Sciences

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The influence of various mechanical influences (transfusion, stirring, vibration, shaking, etc.) and magnetic installations (used in the application of spin chemistry methods) on colloidal solutions of protein and water, which are often used in pharmaceutical production, was studied. It has been shown that when mechanical influences are applied, physical and chemical properties of water and aqueous colloids of the IgG protein are changed. Magnetic fields do not have a significant effect on water; however, variation in a number of physical and chemical characteristics is observed in protein colloids. Moreover, the effect after exposure to magnetic fields with a frequency of 8 Hz is higher compared to the effect after exposure to magnetic fields with a frequency of 50 Hz. This effect persists even at extremely low concentrations of IgG protein molecules. The measurement system proposed in this work makes it possible to monitor the state of protein molecules in a non-invasive mode. In the future, optical and potentiometric methods built into flow systems can be used at all stages of the production of protein pharmaceuticals.

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Section: Influence Of Magnetic Field and Mechanical Action By Pipetti...mentioning

confidence: 88%

Possible Approaches to Studying the Influence of Magnetic Fields and Mechanical Effects on the Physicochemical Properties of Aqueous IgG Colloids

Nagaev,

Molkova,

Pustovoy

et al. 2023

Applied Sciences

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“…It is thought that this situation is similar to the hormesis phenomenon. Microinjury of the ear skin with the effect of microneedling may have reduced the inflammatory effect of edema formation with xylene due to the preconditioning [73,74].…”

Section: In Vivo Studiesmentioning

confidence: 99%

Development and In Vitro - In Vivo Evaluation of Composite Hydrogel-Forming Microneedles Containing Diclofenac Sodium with Box-Behnken Design Using SLA 3D-Printed Microneedle Molds

Tunçel,

Tort,

Han

et al. 2024

Preprint

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With developing manufacturing technologies, the use of 3D printers in microneedle production is becoming widespread. In recent years, microneedles have gained considerable popularity as dermal drug delivery systems. Hydrogel-forming microneedles (HFMs), a variant of microneedles, demonstrate distinctive features such as a high loading capacity, controlled drug release, and enhanced drug absorption. In this study, the molds, created using a Stereolithography (SLA) 3D printer, were utilized to create composite HFMs containing diclofenac sodium. Using an experimental design approach (Box–Behnken Design), the effects of different polymers on the in vitro performance of the developed HFMs, as well as the impact of polymer mixtures on microneedle formation were investigated. The skin penetration and drug release properties of the proposed formulations were assessed. Ex vivo studies were conducted on formulations to determine drug penetration and accumulation in tissue, and the MTT testing revealed non-cytotoxicity. Subsequently, in in vivo studies, the efficacy of the optimal formulation was assessed for the treatment of xylene-induced ear edema by contrasting it to the conventional dosage form. As a result, it was observed that HFMs could provide high amounts of drug accumulation in the skin tissue.

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“…It has been demonstrated that overexpression of HSPB1 can inhibit erastin‐induced ferroptosis in cancer cells and that this process was dependent on HSF1, 104 underscoring the key role of HF1‐HSPB1 in inhibiting ferroptosis. Xu et al showed that heat shock preconditioning had a preventive effect on pressure injuries via HSP27 upregulation in rat models 105 . Although it is currently unclear whether heat shock proteins can mitigate ferroptotic cell death in the context of DTIs, considering the pathogenic role of ferroptosis in DTIs and the protective role of HSPB1 in pressure injuries, this may provide new insights into the potential role of ferroptosis in the pathophysiological processes of DTIs.…”

Section: Implications Of Ferroptosis In Dtismentioning

confidence: 99%

The potential role of ferroptosis in the physiopathology of deep tissue injuries

Han,

Pei,

Tao

et al. 2023

International Wound Journal

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Deep tissue injuries (DTIs) are a serious type of pressure injuries that mainly occur at the bony prominences and can develop rapidly, making prevention and treatment more difficult. Although consistent research efforts have been made over the years, the cellular and molecular mechanisms contributing to the development of DTIs remain unclear. More recently, ferroptosis, a novel regulatory cell death (RCD) type, has been identified that is morphological, biochemical and genetic criteria distinct from apoptosis, autophagy and other known cell death pathways. Ferroptosis is characterized by iron overload, iron‐dependent lipid peroxidation and shrunken mitochondria. We also note that some of the pathological features of DTI are known to be key features of the ferroptosis pathway. Numerous studies have confirmed that ferroptosis may be involved in chronic wounds, including DTIs. Here, we elaborate on the basic pathological features of ferroptosis. We also present the evidence that ferroptosis is involved in the pathology of DTIs and highlight a future perspective on this emerging field, desiring to provide more possibilities for the prevention and treatment of DTIs.

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Effect of Heat Shock Preconditioning on Pressure Injury Prevention via Hsp27 Upregulation in Rat Models

Cited by 3 publications

References 52 publications

Possible Approaches to Studying the Influence of Magnetic Fields and Mechanical Effects on the Physicochemical Properties of Aqueous IgG Colloids

Possible Approaches to Studying the Influence of Magnetic Fields and Mechanical Effects on the Physicochemical Properties of Aqueous IgG Colloids

Development and In Vitro - In Vivo Evaluation of Composite Hydrogel-Forming Microneedles Containing Diclofenac Sodium with Box-Behnken Design Using SLA 3D-Printed Microneedle Molds

The potential role of ferroptosis in the physiopathology of deep tissue injuries

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