Effect of He-Ne laser radiation on lipids in platelets

Trofimov, V. A.; Kiseleva, R. E.; Vlasov, A. P.; Minnebaev, M. M.; Nikolaev, V. T.

doi:10.1007/bf02432795

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…Charge modification results in changes in the entire structure of the cell membrane. R/NIR leads to conformational changes in membrane proteins or transport 45 , resulting in the activation of a cellular system, and the synthesis of the secondary messengers 47 . Such assumptions indicate that the cell membrane structure is involved in the modification of PLT activity by light.…”

Section: Discussionmentioning

confidence: 99%

Low-level light therapy reduces platelet destruction during extracorporeal circulation

Drohomirecka

Iwaszko

Walski

et al. 2018

Sci Rep

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Extracorporeal circulation causes many deleterious effects on blood cells. Low-level light therapy (LLLT) in the red/near-infrared spectral range is known for its cytoprotective properties but its use during cardiopulmonary bypass (CPB) has not yet been studied. We aimed to assess whether LLLT protects platelets during CPB. 24 pigs were connected to 1-hour-CPB and observed for the next 23 hours. In 12 animals, blood circulating through the oxygenator was treated with LLLT. Platelet count and function were monitored throughout the experiment. The decrease in platelet count was greater in the control group, especially during CPB and after 24 hours. In LLLT group CD62P expression remained quite stable up to the 12th hour of the experiment, whereas in the control group it continuously decreased till the end of observation. Platelets in the control group were more prone to aggregation in the postoperative period than at the beginning of the experiment, whereas platelets in the LLLT group aggregated similarly or less intense. Limitation of platelet loss, pattern of aggregation and CD62P expression suggest that LLLT may stabilize platelet function during CPB and diminish the negative effects associated with the interaction of cells with an artificial surface.

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Section: Discussionmentioning

confidence: 99%

Low-level light therapy reduces platelet destruction during extracorporeal circulation

Drohomirecka

Iwaszko

Walski

et al. 2018

Sci Rep

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“…The molecular pathogenetic mechanism of peritonitis includes profound changes in blood plasma lipids [7]. Twenty-four hours after BP modeling the contents of cholesterol and β-lipoproteins increased to 4.42±0.22 mmol/liter (p<0.01) and 35.47±3.29 U (p<0.001), respectively.…”

Section: Resultsmentioning

confidence: 96%

Water-electrolyte balance, lipid and protein metabolism, and state of cell plasma membranes during experimental bile peritonitis

Petrosyan¹,

Сергиенко²,

Gorbov³

et al. 2005

Bull Exp Biol Med

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“…Finally, R/NIR radiation causes biochemical changes in the membrane of PLTs in the lipid phase 35 , 40 , 41 . The authors suggest that the observed changes in the microviscosity of the lipid bilayer, also in the contact regions of lipids and proteins, may cause the activation of the cellular regulatory system and the synthesis of secondary messengers 40 . Such assumptions indicate that cell membrane structures contribute to the light modification of PLT activity.…”

Section: Discussionmentioning

confidence: 99%

Near-infrared photobiomodulation of blood reversibly inhibits platelet reactivity and reduces hemolysis

Walski

Grzeszczuk-Kuć

Gałecka

et al. 2022

Sci Rep

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Photobiomodulation (PBM) in the red/near-infrared (R/NIR) spectral range has become widely recognized due to its anti-inflammatory and cytoprotective potential. We aimed to assess the effects of blood PBM on platelets function and hemolysis in an in vitro setting. Porcine blood samples were separated into four aliquots for this study, one of which served as a control, while the other three were subjected to three different NIR PBM dosages. The platelet count and functions and the plasma free haemoglobin and osmotic fragility of red blood cells were measured during the experiment. The control group had a considerable drop in platelet number, but the NIR exposed samples had more minimal and strictly dose-dependent alterations. These modifications were consistent with ADP and collagen-induced platelet aggregation. Furthermore, red blood cells that had received PBM were more resistant to osmotic stress and less prone to hemolysis, as seen by a slightly lower quantity of plasma free hemoglobin. Here we showed under well-controlled in vitro conditions that PBM reversibly inhibits platelet activation in a dose-dependent manner and reduces hemolysis.

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Effect of He-Ne laser radiation on lipids in platelets

Cited by 4 publications

References 5 publications

Low-level light therapy reduces platelet destruction during extracorporeal circulation

Low-level light therapy reduces platelet destruction during extracorporeal circulation

Water-electrolyte balance, lipid and protein metabolism, and state of cell plasma membranes during experimental bile peritonitis

Near-infrared photobiomodulation of blood reversibly inhibits platelet reactivity and reduces hemolysis

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