Effect of hawthorn seed extract on the gastrointestinal function of rats with diabetic gastroparesis

Niu, Zhenzhen; Yan, Meixing; Zhao, Xinling; Jin, Hongyu; Gong, Yanling

doi:10.1016/j.sajb.2020.01.032

Cited by 16 publications

(14 citation statements)

References 24 publications

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“…Today, Crataegus berries and flowers are officially recognized as herbal raw materials and have been included in European, American, and Canadian pharmacopeias. Recent research confirmed and extended the possibilities of the traditional use of this plant, among others, to anti-inflammatory [ 8 , 9 ], anti-oxidant [ 10 , 11 ], anti-aging [ 12 ], anti-depressant [ 13 ], anti-viral, anti-fungal, anti-bacterial [ 14 ], hypoglycemic, hepatoprotective [ 15 ], gastroprotective [ 16 ], immunostimulatory, hypolipidemic, hypocholesterolemic, and anti-atherosclerotic effects [ 17 ]. Furthermore, Crataegus extracts are considered as putative therapeutic agents for the treatment of hepatocellular carcinoma, breast cancer, melanoma, and colorectal cancer [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells

et al. 2021

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Crataegus contains numerous health-promoting compounds that are also proposed to have anti-cancer properties. Herein, we aimed at a contemporaneous evaluation of the effects of polyphenol-rich extracts of berries, leaves, and flowers of six Crataegus species on the viability and invasive potential on the highly aggressive human glioblastoma U87MG cell line. The treatment with the extracts evoked cytotoxic effects, with the strongest in the berry extracts. All extracts not only promoted the apoptosis-related cleavage of poly (ADP-ribose) polymerase 1 (PARP1) but also substantially inhibited the activity of pro-survival kinases, focal adhesion kinase (FAK), and protein kinase B (PKB; also known as Akt), thus indicating the suppression of proliferative and invasive potentials of the examined glioblastoma cells. The qualitative and quantitative characterization of the extracts’ content was also performed and revealed that amongst 37 polyphenolic compounds identified in the examined Crataegus extracts, the majority (29) was detected in berries; the leaf and flower extracts, exerting milder cytotoxic effects, contained only 14 and 13 compounds, respectively. The highest polyphenol content was found in the berries of C. laevigata x rhipidophylla x monogyna, in which flavan-3-ols and phenolic acids predominated. Our results demonstrated that a high content of polyphenolic compounds correlated with the extract cytotoxicity, and especially berries were a valuable source of compounds with anti-cancer potential. This might be a promising option for the development of an effective therapeutic strategy against highly malignant glioblastomas in the future.

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Section: Introductionmentioning

confidence: 99%

Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells

et al. 2021

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“…Furthermore, the risk of developing DGP, being over 7 and 30-times for T2DM and T1DM, respectively. DGP is a highly symptomatic disorder determined by fullness, anorexia [ 66 ], early satiety, abdominal pain [ 67 ], weight loss, abdominal distension, nausea and vomiting [ 68 ], gastric dysrhythmia, antral hypomotility, and/or delayed gastric emptying [ 65 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

“…Numerous factors such as autonomic system neuropathy, disturbance in neurotransmission [ 69 ], hyperglycemia, neurological disorders, alterations in gastrointestinal (GI) hormones, microvascular and GI smooth muscle abrasions, and structural and practical irregularity of interstitial cells of Cajal (ICC) are involved in the pathogenesis of DGP [ 68 ]. Hyperglycemia-induced oxidative stress is a major mechanism for various complications of diabetes including DGP and leads to cellular malfunction and tissue damage [ 70 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

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Molecular Mechanisms of Hawthorn Extracts in Multiple Organs Disorders in Underlying of Diabetes: A Review

Gheitasi

Savari

Akbari

et al. 2022

International Journal of Endocrinology

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Diabetes mellitus (DM) is one of the most important metabolic disorders associated with chronic hyperglycemia and occurs when the body cannot manage insulin secretion, insulin action, or both. Autoimmune destruction of pancreatic beta cells and insulin resistance are the major pathophysiological factors of types 1 and 2 of DM, respectively. Prolonged hyperglycemia leads to multiple organs dysfunctions, including nephropathy, neuropathy, cardiomyopathy, gastropathy, and micro- and macrovascular disorders. The basis of the metabolic abnormalities in carbohydrate, fat, and protein in diabetes is insufficient action of insulin on various target tissues. Medicinal plants are rich sources of bioactive chemical compounds with therapeutic effects. The beneficial effects of leaves, fruits, and flowers extracts of Crataegus oxyacantha, commonly called hawthorn, belonging to the Rosaceae family, are widely used as hawthorn-derived medicines. Data in this review have been collected from the scientific articles published in databases such as Science Direct, Scopus, PubMed, Web of Science, and Scientific Information Database from 2000 to 2021. Based on this review, hawthorn extracts appear both therapeutic and protective effects against diabetic-related complications in various organs through molecular mechanisms, such as decreasing triglyceride, cholesterol, very low density lipoprotein and increasing the antioxidant activity of superoxide dismutase, catalase, glutathione peroxidase, total antioxidant capacity, decreasing malondialdehyde level, and attenuating tumor necrosis factor alpha, interleukin 6 and sirtuin 1/AMP-activated protein kinase (AMPK)/nuclear factor kappa B (NF-κB) pathway and increasing the phosphorylation of glucose transporter 4, insulin receptor substrate 1, AKT and phosphoinositide 3-kinases, and attenuating blood sugar and regulation of insulin secretion, insulin resistance, and improvement of histopathological changes in pancreatic beta cells. Collectively, hawthorn can be considered as one new target for the research and development of innovative drugs for the prevention or treatment of DM and related problems.

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“…As indicated above, many beneficial properties have been attributed to hawthorn, including anticancer [55], anti-HIV, anti-diabetic [56], and anticoagulant activity [57], cardioprotective effects [58][59][60][61][62][63][64][65], hepatoprotective effects, antihyperglycemic and antihyperlipidemic activities, wound healing effects [66], antimicrobial effects, gastroprotective effects, treatment of metabolic syndrome [67], regulation of cholesterol homeostasis [68], anti-atherosclerosis effects [69][70][71][72], anti-aging effects [73], ischemia protective effects [74], treatment of cognitive disorders, neuroprotective effects, regulating gastrointestinal motility [75], anti-inflammatory activities [76,77], regulation of the gut-brain axis [78], treatment of hypertension [79], antioxidant activity [80][81][82][83][84][85], anti-hypoxic activities [86], antidepressant effects [87], anti-Alzheimer's effects, and treatment of intestinal microbial disorder [88].…”

Section: In Vitro and In Vivo Therapeutic Potentials Of Hawthorn: An mentioning

confidence: 99%

Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties

Nazhand

Lucarini²,

Durazzo³

et al. 2020

Forests

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Medicinal plants, many of which are wild, have recently been under the spotlight worldwide due to growing requests for natural and sustainable eco-compatible remedies for pathological conditions with beneficial health effects that are able to support/supplement a daily diet or to support and/or replace conventional pharmacological therapy. The main requests for these products are: safety, minimum adverse unwanted effects, better efficacy, greater bioavailability, and lower cost when compared with synthetic medications available on the market. One of these popular herbs is hawthorn (Crataegus spp.), belonging to the Rosaceae family, with about 280 species present in Europe, North Africa, West Asia, and North America. Various parts of this herb, including the berries, flowers, and leaves, are rich in nutrients and beneficial bioactive compounds. Its chemical composition has been reported to have many health benefits, including medicinal and nutraceutical properties. Accordingly, the present review gives a snapshot of the in vitro and in vivo therapeutic potential of this herb on human health.

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Effect of hawthorn seed extract on the gastrointestinal function of rats with diabetic gastroparesis

Cited by 16 publications

References 24 publications

Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells

Polyphenolic Compounds of Crataegus Berry, Leaf, and Flower Extracts Affect Viability and Invasive Potential of Human Glioblastoma Cells

Molecular Mechanisms of Hawthorn Extracts in Multiple Organs Disorders in Underlying of Diabetes: A Review

Hawthorn (Crataegus spp.): An Updated Overview on Its Beneficial Properties

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