Effect of haloperidol on the development of the solid ehrlich tumor in mice

Kleeb, Silvia Regina; Xavier, José Guilherme; Frussa‐Filho, Roberto; Dagli, M.L.

doi:10.1016/s0024-3205(96)00636-4

Cited by 21 publications

(13 citation statements)

References 7 publications

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“…transplantations of 2.5 Â 10 6 tumor cells. To the experiments with solid tumor, 2.5 Â 10 6 tumor cells were injected in a volume of 0.05 mL in the footpad of rats (Kleeb et al, 1997).…”

Section: Ehrlich Ascitic and Solid Tumormentioning

confidence: 99%

Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice

Pereira

Barbosa

et al. 2013

Drug Delivery

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Context: Methotrexate (MTX) is used in the treatment of malignancies; however, its clinical application is limited by its toxic dose-related side effects. An alternative to overcome the toxicity of the MTX in healthy tissues is the design of an implantable device capable of controlling the delivery of this drug for an extended period within the tumor site. Objective: To develop methotrexate-loaded poly("-caprolactone) implants (MTX PCL implants) and to demonstrate their efficacy as local drug delivery systems capable of inhibiting Ehrlich solid tumor bearing mice. Materials and methods: MTX PCL implants were produced by the melt-molding technique and were characterized by FTIR, WAXS, DSC and SEM. The in vitro and in vivo release of MTX from the PCL implants was also evaluated. The efficacy of implants in inhibiting tumor cells in culture and the solid tumor in a murine model was revealed. Results and discussion: The chemical and morphological integrity of the drug was preserved into the polymeric matrix. The in vitro and in vivo release processes of the MTX from the PCL implants were modulated by diffusion. MTX diffused from the implants revealed an antiproliferative effect on tumor cells. Finally, MTX controlled and sustained released from the polymeric implants efficiently reduced 42.7% of the solid tumor in mice paw. Conclusion: These implantable devices represented a contribution to improve the efficacy and safety of chemotherapy treatments, promoting long-term local drug accumulation in the targeted site.

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“…transplantations of 2.5 Â 10 6 tumor cells. To the experiments with solid tumor, 2.5 Â 10 6 tumor cells were injected in a volume of 0.05 mL in the footpad of rats (Kleeb et al, 1997).…”

Section: Ehrlich Ascitic and Solid Tumormentioning

confidence: 99%

Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice

Pereira

Barbosa

et al. 2013

Drug Delivery

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“…Ehrlich ascitic tumor (EAT) is an experimental tumor model, characterized by a spontaneous murine carcinoma that can grow rapidly in almost any mouse strain, producing ascitic or solid tumors across histocompatibility barriers [14,15,16,17,18]. In the present study, we aimed to verify whether sleep deprivation, occurring during tumor development, would have a potentiating effect on EAT growth in female mice and if this possible potentiating effect would have an influence on the survival of mice.…”

Section: Introductionmentioning

confidence: 99%

Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

Maragno-Correa

Patti

Zanin

et al. 2013

Neuroimmunomodulation

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Objectives: Sleep deprivation is a growing public health hazard, yet it is still under-recognized. Sleep disorders and disruption of sleep patterns may compromise the immune function and adversely affect host resistance to infectious diseases. This is a particular risk in cancer patients, who report a high frequency of sleep disturbances. The present study investigated the effects of sleep deprivation on the development of Ehrlich ascitic tumors (EAT) in female BALB/c mice. Our study also evaluated whether EAT would induce alterations in sleep pattern. Spleen lymphocyte cell populations and mortality were also quantified. Methods: Female BALB/c mice were intraperitoneally inoculated with EAT cells. Immediately after the inoculation procedure, animals were sleep deprived for 72 h. Ten or 15 days after inoculation, the number of tumoral cells was quantified and the lymphocytic cell population in the spleen was characterized by flow cytometry. In addition, the effect of sleep deprivation on EAT-induced mortality was quantified and the influence of EAT on sleep patterns was determined. Results: Sleep deprivation did not potentiate EAT growth, but it significantly increased mortality. Additionally, both EAT and sleep deprivation decreased frequencies of splenic CD4+, CD8+ and CD19+ cells. With respect to sleep patterns, EAT significantly enhanced paradoxical sleep time. Conclusions: Although sleep deprivation did not potentiate EAT growth, it decreased the survival of female tumor-bearing mice.

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“…The reliable criteria for judging the value of any anti cancer drug are the prolongation of life span of animals 16 . A reduction in the number of ascetic tumor cells may indicate either an effect of MESP on peritoneal macrophages or other components of the immune system 17 , therefore increasing their capacity of killing the tumor cells, or a direct effect on the tumor cell growth. MESP is inhibiting significantly the tumor volume, viable cell count and enhancement in survival time of DAL bearing mice and there by acts as anti-neoplastic agent.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Phytochemical and Pharmacological Activity of Methanolic Extract of Solanum Pubescens

Hemamalini¹,

Bhargav²

2013

Int. Res. J. Pharm.

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Traditional medicine has a long history of serving people all over the world. In recent years, the use of traditional medicine information in cancer research received considerable interest. Solanum pubescens has been used in traditional and folklore medicine for the treatment of cancer. The aim of the present study was to evaluate the effect of methanol extract of the leaves against intraperitoneally injected Dalton's Ascitic Lymphoma (DAL) cell line in swiss albino mice. DAL cells were injected intraperitoneally (1 ×10 6 cells / ml / mouse) to the mice. The MESP at a dose of 100 mg / kg and 200 mg / kg body weight were administered orally for 14 consecutive days to the tumor bearing group of animals. Derived parameters, haematological parameters, serum enzyme and lipid parameters were measured and compared to the cancer control group. 5-Flurouracil (20 mg / kg) was used as a standard. Both the dose of MESP decreased average increase in body weight, reduced the packed cell volume, viable tumor cell count and increased the life span of DAL treated mice and brought back the haematological parameters, serum enzyme and lipid profile near to normal values. All the values were found to be statistically significant with cancer control group at P < 0.01. These observations are suggestive of the protective effect of extracts in Dalton's Ascitic Lymphoma (DAL). All these findings enable to conclude that MESP at 200 mg / kg dose possess a protective effect against DAL.

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Effect of haloperidol on the development of the solid ehrlich tumor in mice

Cited by 21 publications

References 7 publications

Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice

Efficacy of methotrexate-loaded poly(ε-caprolactone) implants in Ehrlich solid tumor-bearing mice

Sleep Deprivation Increases Mortality in Female Mice Bearing Ehrlich Ascitic Tumor

Evaluation of Phytochemical and Pharmacological Activity of Methanolic Extract of Solanum Pubescens

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