Effect of haemodialysis and residual renal function on serum levels of galectin‐3, B‐type natriuretic peptides and cardiac troponin T

Roberts, Matthew A; Srivastava, Piyush; Hare, David; Ierino, Francesco L.

doi:10.1111/nep.13179

Cited by 6 publications

(4 citation statements)

References 34 publications

(37 reference statements)

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“…When looking at both corrected and uncorrected estimates, three estimates are based on LF-HD 4,16,20 and all report an increase in hs-cTnT after HD. Six estimates (corrected and uncorrected) are available for HF-HD 5,[14][15][16]18 and they range from À16% to 12%. However, one uncorrected estimate 14 are based on patients with a large UF (mean 2.7 L at baseline), increasing the effect from hemoconcentration due to UF.…”

Section: Discussionmentioning

confidence: 99%

The short‐term effect of hemodialysis on the level of high‐sensitive cardiac troponin T — A systematic review

Hunderup,

Kampmann,

Kristensen

et al. 2023

Seminars in Dialysis

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IntroductionPatients with end‐stage renal disease (ESRD) have an increased risk of cardiovascular disease, but interpreting cardiac troponin is difficult in this population. The effect of renal replacement therapy (RRT) is important to consider when interpreting serial cardiac troponin T (cTnT) results for patients with ESRD suspected of acute coronary syndrome (ACS). The aim of this systematic review is to answer how low‐flux hemodialysis (LF‐HD), high‐flux hemodialysis (HF‐HD), and hemodiafiltration (HDF) affect the blood concentration of high‐sensitive cardiac troponin T (hs‐cTnT).MethodSeveral databases were searched and identified records were evaluated independently by two of the authors. Pre‐ and postdialysis hs‐cTnT concentrations together with other relevant data were extracted from the included studies. The quality (potential bias and applicability issues) were assessed for each of the included studies.ResultsThe literature search identified 2,540 records and 15 studies were included. The relative pre‐ to postdialysis change of hs‐cTnT varied from −41 to 29%. LF‐HD increased the hs‐cTnT concentration with relative changes between 2 and 17%. HDF decreased the concentration with relative changes from −41% to −9%. Both increases and decreases were seen for HF‐HD (−16% to 12%).Discussion/ConclusionIn this systematic review, we found LF‐HD to increase the hs‐cTnT concentration and HDF to decrease the concentration. Results for HF‐HD and unspecified HD are more heterogeneous. Because of the differences between the included studies, a meta‐analysis was not meaningful. This systematic review can help with the assessment of patients with ESRD suspected of ACS in relation to hemodialysis/HDF treatment.

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Section: Discussionmentioning

confidence: 99%

The short‐term effect of hemodialysis on the level of high‐sensitive cardiac troponin T — A systematic review

Hunderup,

Kampmann,

Kristensen

et al. 2023

Seminars in Dialysis

View full text Add to dashboard Cite

show abstract

“…In addition, all maintenance HD patients were Asian in the present study, thus the generalizability of the study findings across ethnicities remains unclear. Third, due to the unavailability of data, several traditional and non-traditional risk factors for CV death, such as serum high sensitivity C-reactive protein, smoking, nutritional parameters and residual renal function or urine volume [ 37 ], were not adjusted in multivariable models. Therefore, as with other studies, our study may be limited by residual confounding.…”

Section: Discussionmentioning

confidence: 99%

Serum Galectin-3 levels and all-cause and cardiovascular mortality in maintenance hemodialysis patients: a prospective cohort study

Liu

Zhang

et al. 2022

BMC Nephrol

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Background Higher serum galectin-3 levels are related to adverse outcomes in different disease states. However, the association of galectin-3 with mortality in the maintenance hemodialysis (HD) population has not been fully described. Thus, we aimed to assess the predictive significance of galectin-3 for all-cause and cardiovascular (CV) mortality through a Chinese maintenance HD population. Methods A prospective cohort study was conducted in five hundred and six patients with end-stage renal disease who underwent hemodialysis at Dalian Central Hospital before December 31, 2014. Serum galectin-3 levels were measured at baseline and classified as high (> 8.65 ng/ml) or low (≤ 8.65 ng/ml) according to the “X-tile” program. Primary and secondary outcomes were all-cause and CV mortality, respectively. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated by the Cox proportional hazards regression models. Results During the median follow-up of 60 months, there were 188 all-cause deaths and 125 CV deaths. Compared with maintenance HD population with galectin-3 ≤ 8.65 ng/ml, the adjusted HR for all-cause mortality among those with galectin-3 > 8.65 ng/ml was 1.59 (CI: 0.96–2.65, p = 0.07). Furthermore, multivariable analysis showed that maintenance HD patients with galectin-3 > 8.65 ng/ml had a 2.13-fold higher risk of CV death than those with galectin-3 ≤ 8.65 ng/ml (HR = 2.13, 95% CI 1.07–4.26). Conclusion Galectin-3 is an independent predictor of CV mortality in maintenance HD patients.

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“…Other studies have shown that the levels of this protein correlate with the glomerular filtration rate in patients with a cirrhosis of the liver [ 31 ] or polycystic ovary [ 32 ]. High concentrations of galectin-3 in plasma have been associated with a risk of chronic kidney disease and are reduced using hemodialysis treatments [ 33 , 34 , 35 ]. It has been reported that an increase in the circulating concentration of galectin-3 (as can be observed in some inflammatory diseases) precedes the decrease in glomerular filtration.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study

et al. 2022

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Catheter-related infections (CRIs) include catheter-associated urinary tract infections (CAUTIs) and central line-associated bloodstream infections (CLABSIs), and they are associated with high morbidity, mortality, and healthcare costs. The diagnosis of a CRI is made difficult by its non-specific symptoms. We aimed to investigate the factors influencing the plasma concentration of galectin-3 in catheter-bearing patients and to explore its potential usefulness as an index for CRIs. Circulating the concentrations of galectin-3, we measured the chemokine (C-C) motif ligand 2, procalcitonin, and C-reactive protein in 110 patients with a central catheter, in 165 patients with a urinary catheter, and in 72 control subjects. Catheter-bearing patients had higher concentrations (p < 0.001) of galectin-3 than the control group [central catheter: 19.1 (14.0–23.4) µg/L; urinary catheter: 17.1 (12.7–25.4) µg/L; control group: 6.1 (5.0–8.7) µg/L]. We identified chronic kidney disease as an independent determinant of galectin-3 concentrations in patients with a central catheter, and serum creatinine, cardiovascular disease, and number of days that the catheter was indwelling were identified as determinants in urinary catheter patients. We found that measuring galectin-3 concentrations in urinary catheter patients with a CRI was more accurate for diagnosis than the other parameters. We conclude that the measurement of galectin-3 concentration may be useful for assessing the inflammatory status of catheter-bearing patients and may contribute to the diagnosis of CRIs in those with a urinary catheter.

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Effect of haemodialysis and residual renal function on serum levels of galectin‐3, B‐type natriuretic peptides and cardiac troponin T

Cited by 6 publications

References 34 publications

The short‐term effect of hemodialysis on the level of high‐sensitive cardiac troponin T — A systematic review

The short‐term effect of hemodialysis on the level of high‐sensitive cardiac troponin T — A systematic review

Serum Galectin-3 levels and all-cause and cardiovascular mortality in maintenance hemodialysis patients: a prospective cohort study

Measurement of Plasma Galectin-3 Concentrations in Patients with Catheter Infections: A Post Hoc Retrospective Cohort Study

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