Effect of Growth Hormone Treatment on Fractures and Quality of Life in Postmenopausal Osteoporosis: A 10-Year Follow-Up Study

Krantz, Emily; Trimpou, Penelope; Landin‐Wilhelmsen, Kerstin

doi:10.1210/jc.2015-1757

Cited by 41 publications

(32 citation statements)

References 20 publications

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“…Since GH treatment has been shown to increase both bone formation and resorption, GH therapy has not been evaluated fully to treat osteoporotic patients. Promisingly, a recent study has reported that GH therapy in postmenopausal women with osteoporosis significantly improved BMD and fracture outcomes after ten years, although overall quality of life measures were unaffected (Krantz et al, 2015). What effect this report will have on the use of GH to treat osteoporosis remains to be seen.…”

Section: Gh/igf Therapymentioning

confidence: 99%

Skeletal effects of growth hormone and insulin-like growth factor-I therapy

Lindsey

Mohan

2016

Molecular and Cellular Endocrinology

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The growth hormone/insulin-like growth factor (GH/IGF) axis is critically important for the regulation of bone formation, and deficiencies in this system have been shown to contribute to the development of osteoporosis and other diseases of low bone mass. The GH/IGF axis is regulated by a complex set of hormonal and local factors which can act to regulate this system at the level of the ligands, receptors, IGF binding proteins (IGFBPs), or IGFBP proteases. A combination of in vitro studies, transgenic animal models, and clinical human investigations has provided ample evidence of the importance of the endocrine and local actions of both GH and IGF-I, the two major components of the GH/IGF axis, in skeletal growth and maintenance. GH- and IGF-based therapies provide a useful avenue of approach for the prevention and treatment of diseases such as osteoporosis.

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Section: Gh/igf Therapymentioning

confidence: 99%

Skeletal effects of growth hormone and insulin-like growth factor-I therapy

Lindsey

Mohan

2016

Molecular and Cellular Endocrinology

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“…A double‐blind, randomized placebo‐controlled study from Sweden investigated the effects of GH treatment for 3 years in postmenopausal women with osteoporosis and showed a 14% increase in BMD . In the 10‐year follow‐up study, a lasting beneficial effect on bone and fracture outcomes was observed compared with controls . Other studies found no positive effects of GH therapy on BMD.…”

Section: Discussionmentioning

confidence: 99%

Associations of insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 with bone quality in the general adult population

Böker

Völzke

Nauck

et al. 2018

Clinical Endocrinology

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“…A double-blind, randomized study conducted in Sweden by Krant et al [28] followed menopausal women with osteoporosis (n = 80) for 10 years, all undergoing estrogenic hormone replacement therapy, where one group received re-combinant GH for 36 months and the other received placebo for 18 months.…”

Section: Gh/igf-1 and Bone Mineral Densitymentioning

confidence: 99%

Growth Hormone Replacement Therapy in Patients without Adult Growth Hormone Deficiency: What Answers Do We Have So Far?

Rucker¹,

Sá²,

Arbex³

2017

Health

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Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) have been suggested as "anti-aging" therapies, or for improving quality of life with aging. In this study, we focus on the actions of GH in the main organs and organ systems of the human body, like skeletal muscle, bones and brain, particularly in regard to data and research on the use of GH replacement therapy in adults without growth hormone deficiency, especially elderly patients. Several different studies have been carried out to show what the effects and side effects of GH replacement in healthy people and what would be the impact in quality of life and life span. In this review, we demonstrate what answers we have so far about the effects of GH replacement in many organs and systems in healthy people.

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Effect of Growth Hormone Treatment on Fractures and Quality of Life in Postmenopausal Osteoporosis: A 10-Year Follow-Up Study

Abstract: GH treatment was beneficial for bone and fracture outcome after 10 years but did not affect the QoL of the women with postmenopausal osteoporosis.

Cited by 41 publications

References 20 publications

Skeletal effects of growth hormone and insulin-like growth factor-I therapy

Skeletal effects of growth hormone and insulin-like growth factor-I therapy

Associations of insulin‐like growth factor‐I and insulin‐like growth factor binding protein‐3 with bone quality in the general adult population

Growth Hormone Replacement Therapy in Patients without Adult Growth Hormone Deficiency: What Answers Do We Have So Far?

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