Effect of growth hormone treatment on the distribution of insulin-like growth factor-I between plasma and lymph of lactating sheep

Davis, S. R.; Hodgkinson, S. C.; Prosser, Colin G.; Gluckman, P. D.; Buonomo, Frances C.; Collier, R. J.

doi:10.1677/joe.0.1320339

Cited by 14 publications

(16 citation statements)

References 12 publications

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“…In both LW and MS pigs, the GH infusion increased plasma IGF-I levels in accordance with previous findings in pigs Sillence and Etherton, 1987;Owens et al, 1990) and sheep (Davis et al, 1992 (Rose et al, 1991) and IGF-I concentrations (Luna et al, 1983;Massa et al, 1992;Olivi6 et al, 1995) has been described during pubertal development. It is followed by a postpubertal decline in plasma GH and IGF-I concentrations (Corpas et al, 1993).…”

Section: Discussionsupporting

confidence: 90%

Effect of a growth hormone infusion on plasma insulin-like growth factor-I in Meishan and Large White pigs

Louveau¹,

Bonneau²

1996

Reprod. Nutr. Dev.

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Summary ― Plasma growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels were determined in Large White (LW) and Meishan (MS) female pigs at 80 and 185 days of age before and after an infusion of porcine GH. Plasma GH concentration declined with age and was similar in both breeds. Plasma IGF-I concentration did not differ between MS and LW pigs at 80 days of age. It increased with age in LW pigs whereas it remained almost unchanged in MS pigs. GH infusion led to an increase in plasma GH concentration and elicited a rapid and persistent rise in plasma IGF-I levels in both breeds. IGF-I response to GH was lower in LW than in MS pigs at 80 days, whereas the reverse was observed at 185 days of age. It increased with age in LW while it declined in MS pigs. The

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Section: Discussionsupporting

confidence: 90%

Effect of a growth hormone infusion on plasma insulin-like growth factor-I in Meishan and Large White pigs

Louveau¹,

Bonneau²

1996

Reprod. Nutr. Dev.

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“…Column chromatography of plasma revealed this material probably represented degraded products of IGFs. These were presumably formed in vivo after internalization of the peptide by cells (Banskota, et al, 1986;Bar, et al, 1986;Schalch, Sessions, Farley, Masakawa, Elmer & Dills, 1986) Lord et al (1991) for lambs and Davis, Hodgkinson, Prosser & Gluckman (1992) for sheep, but differs from human lymph (Binoux & Hossenlopp, 1988) in that the latter is virtually devoid of the doublet running at 41-46 kDa.…”

Section: Discussionmentioning

confidence: 99%

Transfer of insulin‐like growth factors I and II from plasma to lymph in young goats

Prosser

Baucells²,

Fleet³

1992

Experimental Physiology

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SUMMARYThe plasma clearance of intravenously injected '25I-labelled insulin-like growth factor I (IGF-I, n = 13) and IGF-II (n = 12) and their transfer into lymph draining the foreleg of 3 5-to 8-week-old British Saanen goats was studied. Both peptides were initially distributed into a volume equivalent to the plasma volume, while the final distribution spaces for IGF-I and IGF-II were 90 + 9-8 and 125 + 12 ml/kg live weight respectively. There were two phases to the plasma clearance of both IGF-I and IGF-II, with the half-lives of both phases for IGF-I (9-6 + 0-9 and 287 + 23 min, first and second phase respectively) being significantly (P < 0 001) longer than those of IGF-II (4-2 + 0-6 and 172 + 18 min, respectively). The radioactivity transferred into lymph originated from intact IGF-I and IGF-II as well as degraded products of these compounds, as assessed by precipitation with trichloroacetic acid and gel filtration. Levels of undegraded IGF-I in lymph were 50 % greater than IGF-II. While more than 90 % of either peptide was bound to specific IGF-binding proteins in plasma, in lymph 34 + 2 % of IGF-I and 23 + 3 % of IGF-II remained in the free form 60-80 min after injection. The plasma: lymph ratio for free IGF-I was 2: 1 and for bound IGF-I, 8:1. The corresponding values for IGF-II were 3:2 and 8:1 respectively. These results provide direct experimental evidence for transfer of undegraded IGF-I and IGF-II from blood into lymph of the foreleg, consistent with the ability of these factors to act in an endocrine role in growing tissues.

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“…was inserted into an efferent lymph duct draining the mam¬ mary gland, exteriorised on the flank of the animal and held in a protective pouch attached to the animal by a harness (Davis et al 1992). The surgery was per¬ formed under general anaesthesia after overnight fasting.…”

Section: Animalsmentioning

confidence: 99%

“…The remaining IGF is associated with several different IGFBPs of approximate molecular mass of 40 kDa. This latter fraction in plasma consists of at least three different IGFBPs: IGFBP-1, (Binoux & Hossenlopp 1988, Lord et al 1991, Cohick et al 1992, Davis et al 1992). The function of the IGFBPs is not completely known, but they have the ability to reduce plasma clearance and restrict passage of IGFs out of the vascular space into tissues (Cascieri et al 1988, Francis et al 1988, Ballard et al 1991).…”

Section: Introductionmentioning

confidence: 99%

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Influence of insulin-like growth factor-binding protein-2 on plasma clearance and transfer of insulin-like growth factors-I and -II from plasma into mammary-derived lymph and milk of goats

Prosser¹,

Schwander²

1996

Journal of Endocrinology

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Plasma clearance of insulin-like growth factors-I and -II (IGF-I and -II) and insulin-like growth factor-binding protein-2 (IGFBP-2) from lactating goats (n = 4) was determined following a single intravenous injection of the corresponding 125I-labelled human protein. Transfer of these proteins out of the vascular space was monitored by their subsequent appearance in mammary-derived lymph and milk. Clearance of 125I-IGFBP-2 from circulation was 0.37 +/- 0.06 ml/min/kg, which is markedly greater than that of 125I-IGF-I or -II (0.11 +/- 0.01 and 0.12 +/- 0.01 ml/min/kg respectively). This was also reflected in longer elimination half-lives for IGF-I (353 +/- 6 min) and -II (254 +/- 8 min) compared with IGFBP-2 (110 +/- 9 min). Three hours after injection of the 125I-labelled protein, the plasma:lymph ratio of trichloroacetic acid-precipitable radioactivity was 1.54 +/- 0.04, 3.3 +/- 0.6 and 4.1 +/- 0.4 for IGFBP-2, IGF-I and -II respectively. The form of 125I-IGFBP-2 in lymph was not different from that of plasma. Elevation of plasma concentrations of IGFBP-2 by its intravenous infusion significantly decreased plasma half-life of both IGF-I and -II (251 +/- 8 and 198 +/- 7 min respectively). Although the amount and rate of transfer of IGF into mammary-derived lymph was decreased slightly by IGFBP-2, concentrations eventually obtained were not different from control. However, secretion of IGFs into milk was significantly reduced by IGFBP-2, particularly in the case of IGF-I. These results are consistent with the ability of all three compounds to cross the vascular endothelium intact and of IGFBP-2 to decrease the uptake of IGF by mammary epithelium and subsequent secretion into milk. IGFBP-2 may well have acted to target plasma IGF towards non-mammary tissues, thus explaining the more rapid plasma clearance of IGFs in the presence of elevated IGFBP-2.

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Effect of growth hormone treatment on the distribution of insulin-like growth factor-I between plasma and lymph of lactating sheep

Cited by 14 publications

References 12 publications

Effect of a growth hormone infusion on plasma insulin-like growth factor-I in Meishan and Large White pigs

Effect of a growth hormone infusion on plasma insulin-like growth factor-I in Meishan and Large White pigs

Transfer of insulin‐like growth factors I and II from plasma to lymph in young goats

Influence of insulin-like growth factor-binding protein-2 on plasma clearance and transfer of insulin-like growth factors-I and -II from plasma into mammary-derived lymph and milk of goats

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