Effect of green tea on pharmacokinetics of 5-fluorouracil in rats and pharmacodynamics in human cell lines in vitro

Qiao, Jie; Gu, Chenxin; Shang, Weihu; Du, Jinglei; Yin, Wei; Zhu, Meilin; Wang, Wei; Han, Mei; Lü, Weidong

doi:10.1016/j.fct.2011.03.033

Cited by 54 publications

(34 citation statements)

References 31 publications

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“…Some recent studies have described this effect for 5-FU, 5 doxorubicin (DOX), 6,7 or tamoxifen. 8 To explain EGCG-induced increased intracellular drug concentration, different mechanisms have been suggested.…”

Section: Alteration Of Anticancer Drug Pharmacokineticsmentioning

confidence: 99%

“…As previously described, increased plasma 5-FU concentration in rats was related to redox activities exerted by EGCG leading to the modulation of the enzyme DPD through its NADPH binding site. 5 Regarding EGCG-induced generation of ROS, hydrogen peroxide production induced by EGCG has been associated with 3-to 6-fold enhancement of cisplatin efficacy in ovarian cancer cells, even in some cell lines highly resistant to the treatment with the drug alone. 24 In leukemia cancer cells, co-treatment with arsenic trioxide (ATO) and EGCG showed oxidative-mediated induction of mitochondrial-dependent apoptosis.…”

Section: Redox Modulation Of Anticancer Drugs Effectmentioning

confidence: 99%

“…Modulation of dihydropyrimidine dehydrogenase (DPD), a rate-limiting enzyme in the elimination of 5-FU, has been recently proposed as underlying event for the significantly increased 5-FU plasma concentration in rats treated with 5-FU and EGCG. 5 The redox activity exerted by EGCG could modulate DPD through its NADPH binding site. This modulation could result in a reduction of 5-FU catabolism thus leading to increased plasma concentrations.…”

Section: Alteration Of Anticancer Drug Pharmacokineticsmentioning

confidence: 99%

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Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

et al. 2013

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s u m m a r yBackground & aims: Green tea catechins, especially epigallocatechin-3-gallate (EGCG), have been associated with cancer prevention and treatment. This has resulted in an increased number of studies evaluating the effects derived from the use of this compound in combination with chemo/radiotherapy. This review aims at compiling latest literature on this subject. Methods: Keywords including EGCG, cancer, chemotherapy, radiotherapy and side effects, were searched using PubMed and ScienceDirect databases to identify, analyze, and summarize the research literature on this topic. Most of the studies on this subject up to date are preclinical. Relevance of the findings, impact factor, and date of publication were critical parameters for the studies to be included in the review. Results: Additive and synergistic effects of EGCG when combined with conventional cancer therapies have been proposed, and its anti-inflammatory and antioxidant activities have been related to amelioration of cancer therapy side effects. However, antagonistic interactions with certain anticancer drugs might limit its clinical use. Conclusions: The use of EGCG could enhance the effect of conventional cancer therapies through additive or synergistic effects as well as through amelioration of deleterious side effects. Further research, especially at the clinical level, is needed to ascertain the potential role of EGCG as adjuvant in cancer therapy.

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Section: Alteration Of Anticancer Drug Pharmacokineticsmentioning

confidence: 99%

Section: Redox Modulation Of Anticancer Drugs Effectmentioning

confidence: 99%

Section: Alteration Of Anticancer Drug Pharmacokineticsmentioning

confidence: 99%

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Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

et al. 2013

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“…EGCG, in particular, has been shown to modulate epigenetic-related enzymes such as DNA methyltransferase. 80 Other cancer preventive effects of GTPs include enhancement of bioavailability of commonly prescribed cancer treatments such as 5-fluorouracil, 81 suggesting that a synergistic relationship between GTPs and cancer drugs may be relevant for cancer prevention.…”

Section: Introductionmentioning

confidence: 99%

Cancer Preventive Effects of Green Tea Polyphenols

Forester

Lambert

2014

Polyphenols in Human Health and Disease

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“…The study found the AUC of 5-FU increased by 524 % and the C max increased by 151 % in the green tea-treated group compared with the controls. The investigators suggested that patients habitually drinking green tea might be candidates for therapeutic drug monitoring if it were consumed concurrently with 5-FU [31].…”

Section: Interaction Assessments Using Animal Modelsmentioning

confidence: 99%

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2017

Planta Med

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Effect of green tea on pharmacokinetics of 5-fluorouracil in rats and pharmacodynamics in human cell lines in vitro

Cited by 54 publications

References 31 publications

Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

Cancer Preventive Effects of Green Tea Polyphenols

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