Effect of green tea extract on obese women: A randomized, double-blind, placebo-controlled clinical trial

Hsu, Cheng Hsiung; Tsai, Tung Hu; Kao, Ying-Jer; Hwang, Kung‐Chang; Tseng, Ting Yu; Chou, Pesus

doi:10.1016/j.clnu.2008.03.007

Cited by 238 publications

(242 citation statements)

References 47 publications

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“…In this regard, it seems unlikely that the lack of effect seen here was due to low dose or short time of experimentation. Nonetheless, clinical studies with active or inactive obese individuals did not support the action of green tea improving glucose homeostasis (HSU et al, 2008;MAKI et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Some authors found reduction of cholesterol in mice (KIM et al, 2009;RICHARD et al, 2009), while others did not find any difference (FARDET et al, 2008;ZHENG et al, 2004). The controversy also exists in clinical studies showing beneficial (HSU et al, 2008;NAGAO;HASE;TOKIMITSU, 2007) or no effect on blood cholesterol (MAKI et al, 2009) after green tea supplementation. Since antioxidant agents such as green and white tea do affect quantitatively the circulating lipoproteins and cholesterol, it is not surprising that they did not affect blood concentration of cholesterol.…”

Section: Discussionmentioning

confidence: 99%

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White tea (Camellia sinensis) extract reduces oxidative stress and triacylglycerols in obese mice

et al. 2012

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White tea is an unfermented tea made from young shoots of Camellia sinensis protected from sunlight to avoid polyphenol degradation. Although its levels of catechins are higher than those of green tea (derived from the same plant), there are no studies addressing the relationship between this tea and obesity associated with oxidative stress.The objective of this study was to evaluate the effect of white tea on obesity and its complications using a diet induced obesity model. Forty male C57BL/6 mice were fed a high-fat diet to induce obesity (Obese group) or the same diet supplemented with 0.5% white tea extract (Obese + WTE) for 8 weeks. Adipose tissue, serum lipid profile, and oxidative stress were studied. White tea supplementation was not able to reduce food intake, body weight, or visceral adiposity. Similarly, there were no changes in cholesterol rich lipoprotein profile between the groups. A reduction in blood triacylglycerols associated with increased cecal lipids was observed in the group fed the diet supplemented with white tea. White tea supplementation also reduced oxidative stress in liver and adipose tissue. In conclusion, white tea extract supplementation (0.5%) does not influence body weight or adiposity in obese mice. Its benefits are restricted to the reduction in oxidative stress associated with obesity and improvement of hypertriacylglycerolemia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

White tea (Camellia sinensis) extract reduces oxidative stress and triacylglycerols in obese mice

et al. 2012

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“…However, findings on the potential effects of tea on high‐density lipoprotein cholesterol (HDL‐C) are mixed. Some clinical trials reported a significant increase,10, 11, 12, 13 whereas other trials reported null effects14 on HDL‐C concentrations. Of note, no clinical trials examined the potential dose‐response effect of tea and were limited by the small sample sizes (10 to ≈200) and short intervention period (3 weeks to 3 months).…”

Section: Introductionmentioning

confidence: 99%

Tea Consumption and Longitudinal Change in High‐Density Lipoprotein Cholesterol Concentration in Chinese Adults

Huang

et al. 2018

JAHA

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BackgroundThe relation between tea consumption and age‐related changes in high‐density lipoprotein cholesterol (HDL‐C) concentrations remains unclear, and longitudinal human data are limited. The aim of current study was to examine the relation between tea intake and longitudinal change in HDL‐C concentrations.Methods and ResultsBaseline (2006) tea consumption was assessed via a questionnaire, and plasma HDL‐C concentrations were measured in 2006, 2008, 2010, and 2012 among 80 182 individuals (49±12 years of age) who did not have cardiovascular diseases or cancer, or did not use cholesterol‐lowering agents both at baseline (2006) and during the follow‐up period (2006–2012). The associations between baseline tea consumption and rate of change in HDL‐C concentrations were examined using generalized estimating equation models. Tea consumption was inversely associated with a decreased rate of HDL‐C concentrations (P‐trend <0.0001) in the fully adjusted model. The adjusted mean difference in the HDL‐C decreased rate was 0.010 (95% confidence interval, 0.008, 0.012) mmol/L per year for tea consumers versus nonconsumers (never or less than once/month group). Interactions between tea consumption and age, sex, lifestyle scores, and metabolic syndrome (all P‐interaction <0.0001) were identified. The associations between greater tea consumption and slower decrease in HDL‐C concentrations were more pronounced in men, individuals aged 60 or older, individuals with a lower lifestyle score, and individuals with metabolic syndrome (all P‐trend <0.0001).ConclusionsTea consumption was associated with slower age‐related decreases in HDL‐C concentrations during 6 years of follow‐up.Clinical Trial Registration URL: http://www.chictr.org. Unique identifier: ChiCTR‐TNRC‐11001489.

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“…[10][11][12][13][14][15][16][17] On the other hand, studies with Caucasian subjects reported mixed results. [18][19][20] Moreover, the amount of regular caffeine intake may also influence the effectiveness of catechins.…”

Section: Introductionmentioning

confidence: 99%

The effects of green tea on weight loss and weight maintenance: a meta-analysis

2009

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Introduction. Different outcomes of the effect of green tea on weight loss (WL) and weight maintenance (WM) have been reported in studies with subjects differing in ethnicity and habitual caffeine intake. Purpose. To elucidate by meta-analysis whether green tea indeed has a function in body weight regulation. Methods. English-language studies about WL and WM after green tea supplementation were identified through PubMed and based on the references from retrieved articles. Out of the 49 studies initially identified, a total of 11 articles fitted the inclusion criteria and provided useful information for the meta-analysis. Effect sizes (mean weight change in treatment versus control group) were computed and aggregated based on a random-effects model. The influence of several moderators on the effect sizes was examined. Results. Catechins significantly decreased body weight and significantly maintained body weight after a period of WL (m ¼ À1.31 kg; Po0.001). Inhibition of this effect by high habitual caffeine intake (4300 mg per day) failed to reach significance (m ¼ À0.27 kg for high andm ¼ À1.60 kg for low habitual caffeine intake; P ¼ 0.09). Also, the seemingly smaller effect of catechins in Caucasian (m ¼ À0.82 kg) subjects compared with Asians (m ¼ -1.51 kg; P ¼ 0.37) did not reach significance. Interaction of ethnicity and caffeine intake was a significant moderator (P ¼ 0.04). Conclusions. Catechins or an epigallocatechin gallate (EGCG)-caffeine mixture have a small positive effect on WL and WM. The results suggest that habitual caffeine intake and ethnicity may be moderators, as they may influence the effect of catechins.

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Effect of green tea extract on obese women: A randomized, double-blind, placebo-controlled clinical trial

Cited by 238 publications

References 47 publications

White tea (Camellia sinensis) extract reduces oxidative stress and triacylglycerols in obese mice

White tea (Camellia sinensis) extract reduces oxidative stress and triacylglycerols in obese mice

Tea Consumption and Longitudinal Change in High‐Density Lipoprotein Cholesterol Concentration in Chinese Adults

The effects of green tea on weight loss and weight maintenance: a meta-analysis

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