The effects of green tea on weight loss and weight maintenance: a meta-analysis

Hursel, Rick; Viechtbauer, Wolfgang; Westerterp-Plantenga, Margriet S.

doi:10.1038/ijo.2009.135

Cited by 258 publications

(102 citation statements)

References 21 publications

(17 reference statements)

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“…It also shows that genetic predisposition may be a moderating factor as previously hypothesized in several manuscripts. The current results support the conclusions of a meta-analysis [10] that showed a seemingly smaller effect of catechins in Caucasian (−0.82 kg; 95% CI: −2.13 to 0.50) subjects compared with Asian subjects (−1.51 kg; 95% CI: −2.37 to −0.65) (21). Jurgens et al [11] drew a similar conclusion from their meta-analysis.…”

Section: Discussionsupporting

confidence: 89%

“…However, a thermogenic effect as well as a weight reducing effect has not been unanimously shown, indicating the presence of moderating factors. The difference in outcome between several ethnic populations suggests a role for genetic predisposition, which was supported by recent meta-analyses [10], [11] that addressed effects of GT on weight loss and thermogenesis. Different polymorphisms for COMT enzyme activity exist and these may be responsible for the variability in flavonoid O-methylation that was previously reported by Hodgson et al [12].…”

Section: Introductionmentioning

confidence: 83%

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The Role of Catechol-O-Methyl Transferase Val(108/158)Met Polymorphism (rs4680) in the Effect of Green Tea on Resting Energy Expenditure and Fat Oxidation: A Pilot Study

et al. 2014

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IntroductionGreen tea(GT) is able to increase energy expenditure(EE) and fat oxidation(FATox) via inhibition of catechol-O-methyl transferase(COMT) by catechins. However, this does not always appear unanimously because of large inter-individual variability. This may be explained by different alleles of the functional COMT Val108/158Met polymorphism that are associated with COMT enzyme activity; high-activity enzyme, COMTH(Val/Val genotype), and low-activity COMTL(Met/Met genotype).MethodsFourteen Caucasian subjects (BMI: 22.2±2.3 kg/m2, age: 21.4±2.2 years) of whom 7 with the COMTH-genotype and 7 with the COMTL-genotype were included in a randomized, cross-over study in which EE and substrate oxidation were measured with a ventilated-hood system after decaffeinated GT and placebo(PL) consumption.ResultsAt baseline, EE, RQ, FATox and carbohydrate oxidation(CHOox) did not differ between groups. Significant interactions were observed between COMT genotypes and treatment for RQ, FATox and CHOox (p<0.05). After GT vs. PL, EE(GT: 62.2 vs. PL: 35.4 kJ.3.5 hrs; p<0.01), RQ(GT: 0.80 vs. PL: 0.83; p<0.01), FATox(GT: 18.3 vs. PL: 15.3 g/d; p<0.001) and CHOox(GT: 18.5 vs. PL: 24.3 g/d; p<0.001) were significantly different for subjects carrying the COMTH genotype, but not for subjects carrying the COMTL genotype (EE, GT: 60.3 vs. PL: 51.7 kJ.3.5 hrs; NS), (RQ, GT: 0.81 vs. PL: 0.81; NS), (FATox, GT: 17.3 vs. PL: 17.0 g/d; NS), (CHOox, GT: 22.1 vs. PL: 21.4 g/d; NS).ConclusionSubjects carrying the COMTH genotype increased energy expenditure and fat-oxidation upon ingestion of green tea catechins vs, placebo, whereas COMTL genotype carriers reacted similarly to GT and PL ingestion. The differences in responses were due to the different responses on PL ingestion, but similar responses to GT ingestion, pointing to different mechanisms. The different alleles of the functional COMT Val108/158Met polymorphism appear to play a role in the inter-individual variability for EE and FATox after GT treatment.Trial RegistrationNederlands Trial register NTR1918

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 83%

The Role of Catechol-O-Methyl Transferase Val(108/158)Met Polymorphism (rs4680) in the Effect of Green Tea on Resting Energy Expenditure and Fat Oxidation: A Pilot Study

et al. 2014

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“…In a meta-analysis of 11 green tea intervention studies with 1226 participants, green tea catechins plus caffeine were effective in promoting weight loss and maintaining weight after a period of negative energy balance, with participants losing an estimated 1.31 kg more/gaining 1.31 kg less on average compared to the control (95% CI: À2.05 to À0.57; P < 0.001). 36 Individual decreases in apparent green tea efficacy through (i) increased habitual caffeine intake or (ii) Caucasian vs. Asian ethnicity were statistically insignificant, yet both remained significant moderators of green tea efficacy (p ¼ 0.04). The importance of caffeine was also highlighted in a meta-analysis of 15 trials (1243 participants) considering body weight, waist circumference, waist to hip ratio and body mass index (BMI).…”

Section: Green Tea and Weight Loss/body Shapementioning

confidence: 93%

Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials

Williamson

Coppens²,

Serra-Majem

et al. 2011

Food Funct.

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We assess the evidence for health benefits of three commonly consumed plant food supplements (PFS), green tea, isoflavone and aloe vera, based on published systematic reviews of randomised controlled trials (RCTs). Whilst the potential benefits of green tea have been reported in a wide range of health areas, it is only in the area of the metabolic syndrome that the number of RCTs is approaching sufficient to judge such efficacy. Isoflavone supplements are widely used, and RCTs indicate that they affect bone resorption at lower doses in postmenopausal women undergoing estrogen-related bone loss, but this is only translated to attenuation of bone loss at higher doses of isoflavones. A systematic review on RCTs concluded that the effects of isoflavones on hot flashes in postmenopausal women were highly variable and no conclusions could be drawn. Despite the popularity of aloe vera as a PFS, the evaluation of its efficacy as a coadjuvant therapy for certain metabolic or digestive pathologies remains scarce; it constitutes a typical example of a naturally occurring ingredient whose efficacy in topical applications presupposes its efficacy in systemic applications. Nevertheless, its possible toxic effects on oral consumption call for caution in its utility as a PFS. Since 2007, efficacy evaluation of PFS in Europe has been covered by European Union Nutrition and Health Claims legislation. The European Food Safety Authority has adopted an approach relying on RCTs, while medicinal effects are accepted based on traditional use. In general, there are insufficient RCTs for claims to be made, and conclusive results on PFS should be obtained in the future by conducting studies with more homogeneous populations, by using supplements with optimised and measured bioavailability, and by conducting larger RCTs.

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“…Also, the optimum consumption pattern is not well understood yet. On the other hand, the available data from similar clinical trials cannot be generalized to other populations as it is strongly supposed that people are genetically predisposed to the effect of epigallocatechin-3-gallate (EGCG)-caffeine mixtures with different extend (15). Considering the importance of the issue and lack of safe, long lasting, and effective strategies, green tea as a costeffective and easy-to-use plant with the least side effects is worthy to be studied.…”

Section: Introductionmentioning

confidence: 99%

The Anti-Obesity Effects of Green Tea: A Controlled, Randomized, Clinical Trial

Nabi¹,

Sedighinejad²,

Haghighi³

et al. 2018

Iran Red Crescent Med J

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Background: Obesity is a global health threatening issue with increasing prevalence in the developed and developing world. The limited efficacy and side effects of conventional treatments motivated the researchers to look for novel, safe, and effective therapeutic strategies. Objectives: The current study aimed at investigating the anti-obesity effects of green tea in a population in North of Iran. Methods: The current single-blind, placebo-controlled, parallel, clinical trial was conducted in Guilan outpatient clinic in Rasht, Iran, from January to December 2015. Eligible subjects were randomly allocated into 2 groups of green tea and control. In the GT Group, a cup of green tea and in the C group an equal amount of mineral water was taken 30 minutes after breakfast and lunch. The outcomes including body weight (BW), body mass index (BMI), hip circumference, waist circumference, and waist-to-hip ratio were measured at baseline, as well as 8 and 12 weeks after the intervention (T0,T_1, T_2).Results: Finally, data obtained from 84 cases in groups GT (n = 41) and C (n = 43) were analyzed. No significant difference was observed in terms of baseline demographics and measurements between the 2 groups including male/female (P = 0.766), age (P = 0.376), weight (P = 0.846), height (P = 0.413), waist circumference (P = 0.619), hip circumference (P = 0.619), and waist-to-hip ratio (P = 0.301). According to the intragroup analyses, the trend of changes from baseline to 12 weeks after intervention were significant in both groups (P = 0.001); BW (79.88 ± 7.06 to 72.44 ± 6.82 kg) and (80.21 ± 7.16 to77.07 ± 7.22 kg) , BMI (29.95 ± 1.79 to 26.86 ± 2.59 kg/m 2 ) and (29.69 ± 2.1 to 27.07 ± 2.22 kg/m 2 ) , waist circumference (87.77±6.06 to 83.913 ± 6.13 cm) and (86.94 ± 8.05 to 85.23 ± 7.89 cm), and hip circumference (102.41 ± 7.35 to 98.3 ± 7.54 cm) and (101.02 ± 8.47 to 99.31 ± 8.81 cm) in GT and C groups, respectively. However no such difference was observed in waist/hip ratio in the GT and C groups (P = 0.087) and (P = 0.322), respectively. A significant difference was observed at T1 (P = 0.024 and P = 0.025) and T2 (P = 0.025 and P = 0.006), according to weight and BMI, respectively. However, the differences were not statistically significant based on the other variables. Conclusions: Green tea could be a safe and effective choice for patients with obesity. However, further well-designed trials are required to confirm these findings.

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The effects of green tea on weight loss and weight maintenance: a meta-analysis

Cited by 258 publications

References 21 publications

The Role of Catechol-O-Methyl Transferase Val(108/158)Met Polymorphism (rs4680) in the Effect of Green Tea on Resting Energy Expenditure and Fat Oxidation: A Pilot Study

The Role of Catechol-O-Methyl Transferase Val(108/158)Met Polymorphism (rs4680) in the Effect of Green Tea on Resting Energy Expenditure and Fat Oxidation: A Pilot Study

Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials

The Anti-Obesity Effects of Green Tea: A Controlled, Randomized, Clinical Trial

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