Effect of Green Tea and Green Tea Rich with Catechin on Blood Glucose Levels , Serum Lipid Profile and Liver and Kidney Functions in Diabetic Rats

Mostafa, Usama

doi:10.12816/0008206

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…39 In addition, research conducted by Mustofa explained that the decrease in triglycerides was caused by catechin being able to inhibit the absorption of exogenous fats from high cholesterol and fat diets. 40 Synthesis of cholesterol is carried out in four stages and begins with acetyl-CoA. The first stage is the synthesis of mevalonate from acetyl-CoA; the second stage converts mevalonate to activated isoprenes; the third stage of squalene synthesis; the fourth stage of cholesterol synthesis.…”

Section: Discussionmentioning

confidence: 99%

Gambir (Uncaria gambir Roxb.) as A Potential Alternative Treatment for Hyperlipidemia

Yunarto

Sulistyaningrum

Kurniatri

et al. 2021

mpk

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Gambir (Uncaria gambir Roxb.) is a member of family of Rubiaceae. In Asia including Indonesia, extracts of gambir are empirically used daily to weed out. The high content of catechin flavonoids in gambir has a pharmacological effect in the treatment of hyperlipidemia that potential to be developed into traditional medicine. This literature review aimed to examine the potency of pharmacological effect of gambir as hyperlipidemia treatment therapy based on the results of studies in silico, in vitro, in vivo pharmacological effects and its safety to provide evidence of scientific information to the community. The literatures used for analysis in this study including evidence-based articles on both pharmacology and safety which are available in Pubmed and Google Scholar. The results showed a very strong potency of gambir plants in the treatment of hyperlipidemia with catechin as bioactive compounds. In silico study revealed mechanism action of catechin as antihyperlipidemic using 2 pathways, inhibition of the enzyme HMG-CoA reductase and increase the LDL receptors. In vitro studies of catechin are able to inhibit lipid absorption in the intestine through inhibition of pancreatic lipase activity, lipid hydrolysis and emulsification, micelle cholesterol deposition. Pre-clinical tests on animals showed that the ethyl acetate fraction of gambir leaves was able to reduce the levels of total cholesterol, triglycerides, LDL and increase blood plasma HDL. The long-term use of gambir leaves has been proven to be safe, not mutagenic, no hematological, clinical biochemical abnormalities and no abnormalities in the vital organs of the animal models. Abstrak Gambir (Uncaria gambir Roxb) adalah tumbuhan perdu dari suku Rubiaceae. Di Asia termasuk Indonesia, secara empiris ekstrak gambir digunakan sehari-hari untuk menyirih. Kandungan flavonoid katekin yang tinggi dalam gambir memiliki efek farmakologi dalam pengobatan hiperlipidemia yang berpotensi untuk dikembangkan menjadi obat tradisional. Kajian literatur ini bertujuan untuk mengkaji potensi farmakologi gambir sebagai terapi pengobatan hiperlipidemia berdasarkan hasil studi efek farmakologi in silico, in vitro, in vivo efek farmakologi dan keamanannya, sehingga memberikan bukti informasi ilmiah kepada masyakarat. Literatur yang digunakan dalam proses review meliputi literatur dengan berbasis bukti baik farmakologi maupun keamanan yang tersedia di Pubmed dan Google Scholar. Hasil kajian menunjukkan potensi yang sangat kuat dari tanaman gambir dalam pengobatan hiperlipidemia dengan katekin sebagai senyawa bioaktif utama. Studi in silico menunjukkan mekanisme aksi katekinsebagai antihiperlipidemia menggunakan dua jalur yaitu penghambatan enzim HMG-CoA reduktase dan peningkatan reseptor LDL. Studi in vitro katekin mampu menghambat penyerapan lipid di usus melalui penghambatan aktivitas lipase pankreas, hidrolisis lipid dan emulsifikasi, serta pengendapan kolesterol misel. Studi in vivo menunjukkan fraksi etil asetat daun gambir mampu menurunkan kadar kolesterol total, trigliserida, LDL dan meningkatkan HDL plasma darah. Penggunaan daun gambir dalam jangka panjang terbukti aman, tidak mutagen, tidak ditemukan kelainan hematologi, biokimia klinis dan tidak menyebabkan kelainan organ vital hewan uji.

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Section: Discussionmentioning

confidence: 99%

Gambir (Uncaria gambir Roxb.) as A Potential Alternative Treatment for Hyperlipidemia

Yunarto

Sulistyaningrum

Kurniatri

et al. 2021

mpk

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“…Catechin Green tea stimulation of NF-κB system through the inhibition cytokines constructions [17] Chocolate Beans Cherry…”

Section: Flavonolmentioning

confidence: 99%

“…This lack of insulin results in a condition Known as diabetes or in laymen dialect, it is known as "Sugar". [13][14][15][16][17][18][19][20][21][22][23][24] It might bring about different dangerous medical problems including heart issue, night visual deficiency, and renal dysfunctioning. This sickness is considered to be the seventh principal reason of death in The United States of America.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Sharma¹

2018

IJGP

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Context: Diabetes mellitus is not a solitary sickness yet is a gathering of metabolic issue influencing countless on the planet. It is essentially described by incessant hyperglycemia because of deformities in insulin discharge or insulin activity. It is predicated that the quantity of diabetes individual on the planet could reach up to 366 million by the year 2030. Even though the instances of diabetes are expanding step by step, aside from insulin and oral hypoglycemic medications, no other method for treatment has been effectively grown up until now. Objective: In the present study, an initiative is tried to delineate the usefulness of prediction of activity spectra for substances (PASS) online software and molecular docking technique for providing new molecular ways of predicting new antidiabetic drug targets of potential phytoconstituents. Materials and Methods: In the study, important phytoconstituents having reported in vitro and in vivo antidiabetic activities have been reviewed. Among them, few phytoconstituents were selected for presenting to PASS online software. Pa and Pi value was predicted for these phytoconstituents on different antidiabetic target sites. Based on PASS prediction, five phytoconstituents were selected for molecular docking study using AutoDock Vina 4.0. Three target sites which were dipeptidyl peptidase-4 (DPP-4), glucagon-like peptide-1 (GLP-1), and α glucosidase were selected for prediction of probable affinities of these 5 selected phytoconstituents. Result and Discussion: Among these five constituents, diosmin showed best binding affinity with DPP-4, GLP-1, and α glucosidase that was −10.2 kcal/mol, −8.3 kcal/mol, and −9.7kcal/mol, followed by kaempferol. Results of the present study can be utilized for designing of further in vitro and in vivo antidiabetic studies for these phytoconstituents. Conclusion: This study suggested the usefulness of these software in predicting the probable antidiabetic targets sites of potential antidiabetic phytoconstituents.

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The protective effect of green tea on diabetes-induced hepato-renal pathological changes: a histological and biochemical study

Atia

Sakr

Damanhory

et al. 2020

Archives of Physiology and Biochemistry

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Effect of Green Tea and Green Tea Rich with Catechin on Blood Glucose Levels , Serum Lipid Profile and Liver and Kidney Functions in Diabetic Rats

Cited by 7 publications

References 20 publications

Gambir (Uncaria gambir Roxb.) as A Potential Alternative Treatment for Hyperlipidemia

Gambir (Uncaria gambir Roxb.) as A Potential Alternative Treatment for Hyperlipidemia

Untitled

The protective effect of green tea on diabetes-induced hepato-renal pathological changes: a histological and biochemical study

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