Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome

Sivaprakasapillai, Brahmesh; Edirisinghe, Indika; Randolph, Jody; Steinberg, Francene M.; Kappagoda, Tissa

doi:10.1016/j.metabol.2009.05.030

Cited by 120 publications

(134 citation statements)

References 18 publications

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“…Thus bioavailability may be underestimated due to poor detection and identification of metabolites [26]. Nonetheless, we have demonstrated previously that flavon-3-ol catechins from GSE are absorbed into the blood and the maximum plasma concentrations (C max ) occurs between 90-120 min after ingestion [27]. In the present study, peak plasma glucose and triglyceride concentrations were observed at 30 and 180 min, respectively after meals [8][9][10].…”

Section: Discussionsupporting

confidence: 50%

Effect of grape seed extract on postprandial oxidative status and metabolic responses in men and women with the metabolic syndrome - randomized, cross-over, placebo-controlled study

Edirisinghe

Randolph

Cheema

et al. 2013

FFHD

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Objective: This investigation was undertaken to determine whether a grape seed extract (GSE) that is rich in mono-, oligo-and poly-meric polyphenols would modify postprandial oxidative stress and inflammation in individuals with the metabolic syndrome (MetS). Background:MetS is known to be associated with impaired glucose tolerance and poor glycemic control. Consumption of a meal high in readily available carbohydrates and fat causes postprandial increases in glycemia and lipidemia and markers of oxidative stress, inflammation and insulin resistance.

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Section: Discussionsupporting

confidence: 50%

Effect of grape seed extract on postprandial oxidative status and metabolic responses in men and women with the metabolic syndrome - randomized, cross-over, placebo-controlled study

Edirisinghe

Randolph

Cheema

et al. 2013

FFHD

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“…For example, GSE have an abundance of proanthocyanidins (39-73%) (Ariga, 2004), and have been shown: to have preventative action against diseases caused by free radicals and reactive oxygen species (Bagchi et al, 2000); to be effective against certain skin cancers (Katiyar Santosh, 2008); to be potentially effective against hypertension (Sivaprakasapillai, Edirisinghe, Randolph, Steinberg, & Kappagoda, 2009); to prevent cardiovascular disease (Du, Guo, & Lou, 2007); and to act as an antibacterial agent (Jayaprakasha, Selvi, & Sakariah, 2003). In food, GSE has been used as a dietary antioxidant supplement (Santos-Buelga & Scalbert, 2000).…”

Section: Introductionmentioning

confidence: 99%

Microwave-assistance provides very rapid and efficient extraction of grape seed polyphenols

et al. 2011

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“…Significant reduction in BP of 11/8 mmHg (p < 0.05) were seen in another dose response study with 150 to 300 mg/d of GSE over 4 wk [306] . GSE has high phenolic content which activates the PI3K/Akt signaling pathway that phosphorylates eNOS and increases NO [306,307] .…”

Section: Additional Compoundsmentioning

confidence: 83%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome

Cited by 120 publications

References 18 publications

Effect of grape seed extract on postprandial oxidative status and metabolic responses in men and women with the metabolic syndrome - randomized, cross-over, placebo-controlled study

Effect of grape seed extract on postprandial oxidative status and metabolic responses in men and women with the metabolic syndrome - randomized, cross-over, placebo-controlled study

Microwave-assistance provides very rapid and efficient extraction of grape seed polyphenols

The role of nutrition and nutraceutical supplements in the treatment of hypertension

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