2000
DOI: 10.1089/107999000750053735
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Effect of Granulocyte-Macrophage Colony-Stimulating Factor on the Generation of Epidermal Langerhans Cells

Abstract: The role of granulocyte-macrophage colony-stimulating factor (GM-CSF) and Flt3 ligand in the in vivo development of Langerhans cells (LC) was assessed, considering both the steady-state levels of LC in the epidermis and the rate of LC recovery after depletion following lipopolysaccharide (LPS) treatment. The density of LC was determined by counting following IA-specific immunofluorescent staining of epidermal sections from mouse ears. LC levels were compared in beta common chain receptor null (beta c(-/-)) mic… Show more

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Cited by 24 publications
(18 citation statements)
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“…In addition, FL expands but does not accelerate splenic DC generation from progenitors, therefore FL administration should have no direct effect on LC recovery after UV light-induced inflammation, which is also in accordance with previous data reporting no effect on LC recovery after LPS-induced depletion. 38 We have shown before that splenic DC numbers derived from either CMPs or CLPs increase relative to the percentage of Flk2 ϩ cells within the progenitor population, but independent of their lineage origin. 28 It is therefore likely that in vivo FL administration has the same promoting effects on CMPs and CLPs during LC development in vivo as observed for conventional splenic DCs, with the exception that total LC numbers in the epidermis are not affected by FL.…”
Section: Discussionmentioning
confidence: 80%
See 1 more Smart Citation
“…In addition, FL expands but does not accelerate splenic DC generation from progenitors, therefore FL administration should have no direct effect on LC recovery after UV light-induced inflammation, which is also in accordance with previous data reporting no effect on LC recovery after LPS-induced depletion. 38 We have shown before that splenic DC numbers derived from either CMPs or CLPs increase relative to the percentage of Flk2 ϩ cells within the progenitor population, but independent of their lineage origin. 28 It is therefore likely that in vivo FL administration has the same promoting effects on CMPs and CLPs during LC development in vivo as observed for conventional splenic DCs, with the exception that total LC numbers in the epidermis are not affected by FL.…”
Section: Discussionmentioning
confidence: 80%
“…In contrast to splenic and thymic DC populations, a direct effect of FL administration on LC development is difficult to determine in vivo, as FL injections do not increase total LC numbers in vivo, 38 which is most likely due to limited numbers of available LC niches in the epidermis. In addition, FL expands but does not accelerate splenic DC generation from progenitors, therefore FL administration should have no direct effect on LC recovery after UV light-induced inflammation, which is also in accordance with previous data reporting no effect on LC recovery after LPS-induced depletion.…”
Section: Discussionmentioning
confidence: 99%
“…The epithelial micro-environment is essential to LC recruitment and differentiation, in particular through local secretion of GM-CSF, TGF-b and the CC chemokine CCL20 (macrophage inflammatory protein (MIP)-3a) [51,84,85,[93][94][95][96][97][98][99][100][101][102]. Other factors, such as the expression of E-cadherin by both epithelial cells and LCs, are important for the tissue homing of these cells [103][104][105].…”
Section: Pathogenesismentioning
confidence: 99%
“…Interestingly, abundant GM-CSF production has also been found in skin LCH lesions, and the LCs in these lesions expressed the GM-CSF receptor [117]. In addition, intradermal injection of GM-CSF into patients with leprosy is associated with accumulation of numerous LCs at the injection site, and skin from transgenic animals that overexpress the GM-CSF gene contains far more epidermal LCs than skin from control animals [95,118,119]. Finally, GM-CSF transfection into the lung of mice promotes the differentiation and activation of a myeloid DC population, primarily by acting on macrophages during pulmonary immune responses [120].…”
Section: Bronchiolar Lc Accumulation In Plchmentioning
confidence: 99%
“…Induction of GM-CSF and IL-6 in the cervical tissues would influence the activation status of local antigen-presenting cells, programming phenotypes that impact the ensuing response to antigens processed by those cells (36)(37)(38)(39). The significance of these two cytokines being preferentially expressed in the ectocervix is consistent with this tissue being the primary site for female 'sampling' of paternal antigens.…”
Section: Discussionmentioning
confidence: 85%