Effect of Gosha-jinki-gan (Chinese herbal medicine: Niu-Che-Sen-Qi-Wan) on insulin resistance in streptozotocin-induced diabetic rats

Effect of Crocin and Voluntary Exercise on P53 Protein in Pancreas of Type2 Diabetic Rats

“…4,5 Crocin is the major active constituents of saffron which used in the traditional medicine for the treatment of numerous diseases including diabetes, depression, cognitive disorders and cancer. 6,7 Some investigations indicate that saffron and its constituents, crocin, have many pharmacological effects on diabetic animal models such as stimulation of glucose uptake by peripheral tissues, 8 inhibition of intestinal glucose absorption, 9 correction of insulin resistance, 10 stimulation and regeneration of beta cells in islets of langerhans to release more insulin. 11,12 As an interest, Hoshyaret al (2013) reported that Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma.…”

The Kampo Medicine Goshajinkigan Prevents Neuropathy in Breast Cancer Patients Treated with Docetaxel

“…GJG is comprised of 10 herbs, each of which contains numerous active ingredients (Figure 3). Two mechanisms have been suggested for the alleviating effects of GJG on peripheral neurotoxicity (Hu et al, 2003;Gotoh et al, 2004;Yamada et al, 2005). The first is that GJG promotes the release of dynorphin, and thus, improves numbness/pallesthesia via the opiate system.…”

Antidiabetic and hypolipidemic activities of ethanolic leaf extract and fractions of Melanthera scandens

“…Some plants' extracts are reported to exert hypoglycemic action by potentiating the insulin effect, either by stimulating the pancreatic secretion of insulin from the cells of islets of langerhans [22] or its release from bound insulin [23] . While others act through extra pancreatic mechanisms by inhibition of hepatic glucose production [24] or corrections of insulin resistance [25] . These leaf extract and fractions may have acted through one of the above mechanisms.…”