Effect of Crocin and Voluntary Exercise on P53 Protein in Pancreas of Type2 Diabetic Rats

Ghorbanzadeh, Vajihe; Mohammadi, Mustafa; Mohaddes, Gisou; Darishnejad, Hassan; Chodari, Leila

doi:10.15171/ps.2017.27

Cited by 17 publications

(12 citation statements)

References 31 publications

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“…In this current study, exercise markedly attenuated the pancreatic apoptotic cells noticed in the stressed group. It was in the same line with Ghorbanzadeh et al (2017) who suggested that voluntary exercise has synergistic anti-apoptotic effects on pancreas tissue of type 2 diabetic rats. Protective effects of this intervention were probably carried out through the reduction of glucose and hemoglobin A1C blood levels of rats suffering from diabetes (Ghorbanzadeh et al 2017).…”

Section: Discussionsupporting

confidence: 73%

Impact of chronic exercise on counteracting chronic stress-induced functional and morphological pancreatic changes in male albino rats

Elbassuoni

Hafez

2019

Cell Stress and Chaperones

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Chronic stress has been linked to many diseases resulted from dysfunction of both the nervous system and peripheral organ systems. Yet, the effects of chronic stress on the pancreas have received relatively little attention. This work aims to investigate the influence of chronic stress exposure on both the endocrine and exocrine pancreatic function and morphology and its possible mechanism of action, and also to evaluate the impact of chronic exercise with moderate intensity on ameliorating the stressinduced pancreatic changes. Forty adult male albino rats were used and divided into four groups: control group, exercised group (3 weeks of swimming exercise), stressed group (3 weeks of immobilization stress), and stressed group practicing exercise (3 weeks of exercise, concomitant with 21 daily sessions of stress). On the final day of the experiment, all rats were sacrificed. Biochemical, immunohistochemical, and histological studies were conducted. The results showed that chronic immobilization stress produced hyperglycemia, hyperinsulinemia, and increased homeostatic model assessment of insulin resistance index (HOMA-IR) with increasing exocrine pancreatic injury markers by increasing oxidative and inflammatory status of the pancreatic tissue. Histological study showed the injurious effect of stress on the morphology of pancreatic tissue. Physical exercise protected the pancreas from the negative effects of stress through its antiinflammatory and anti-oxidative effects, evidenced by increasing pancreatic interleukin 10 and total antioxidant capacity and decreasing pancreatic tumor necrosis factor-alpha, and malondialdehyde with ameliorating most of the histological changes induced by stress exposure. Physical exercise effectively counteracts chronic stressinduced pancreatic changes through different mechanisms.

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Section: Discussionsupporting

confidence: 73%

Impact of chronic exercise on counteracting chronic stress-induced functional and morphological pancreatic changes in male albino rats

Elbassuoni

Hafez

2019

Cell Stress and Chaperones

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“…An increase in leptin mRNA and protein has also been reported following the crocin supplementation in animal models of diabetes mellitus (37). On the other hand, the protective effect of crocin on glycemic control can be attributed to induction of the GLUT4 expression/localization, improvement in β-cell function, lowering of free fatty acids and triglycerides, and suppression of in ammatory responses (36,(38)(39)(40)(41). In support of our nding, in an experiment conducted by Shirali et al (24), crocin could signi cantly decrease hemoglobin A1c and insulin resistance in diabetic rats, probably through prevention of oxidative stress and improvement of lipid pro le.…”

Section: Discussionmentioning

confidence: 98%

The Effect of Crocin Supplementation on Glycemic Control, Insulin Resistance and Active AMPK Levels in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Behrouz¹,

Dastkhosh²,

Hedayati³

et al. 2020

Preprint

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Background Crocin as a carotenoid exerts anti-oxidant, anti-inflammatory, anti-cancer, neuroprotective and cardioprotective effects. Besides, the increasing prevalence of diabetes mellitus and its allied complications, and also patients' desire to use natural products for treating their diseases, led to the design of this study to evaluate the efficacy of crocin on glycemic control, insulin resistance and active adenosine monophosphate-activated protein kinase (AMPK) levels in patients with type-2 diabetes (T2D). Methods In this clinical trial with a parallel-group design, 50 patients with T2D received either 15-mg crocin or placebo, twice daily, for 12 weeks. Anthropometric measurements, dietary intake, physical activity, blood pressure, glucose homeostasis parameters, active form of AMPK were assessed at the beginning and at the end of the study.Results Compared with the placebo group, crocin improved fasting glucose level (P=0.015), hemoglobin A1c (P=0.045), plasma insulin level (P=0.046), insulin resistance (P=0.001), and insulin sensitivity (P=0.001). Based on the within group analysis, crocin led to significant improvement in plasma levels of glucose, insulin, hemoglobin A1c, systolic blood pressure, insulin resistance and insulin sensitivity. The active form of AMPK did not change within and between groups after intervention. Conclusions The findings indicate that crocin supplementation can improve glycemic control and insulin resistance in patients with T2D. Further studies are needed to confirm these findings. Trial Registration This study has been registered at Clinicaltrial.gov with registration number NCT04163757.

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“…It is proposed that crocin can decrease myocardial apoptosis through reducing the Bax/Bcl‐2 ratio and normalizing the autophagy dysfunction in diabetic myocardium via increasing the phosphorylation of AMPK (Feidantsis, Mellidis, Galatou, Sinakos, & Lazou, 2018). Furthermore, crocin has inhibitory effects on beta‐cell apoptosis by reducing P53 levels (Ghorbanzadeh, Mohammadi, Mohaddes, Darishnejad, & Chodari, 2017). Roshanravan et al reported that crocin decreased FBG insignificantly, which might be due to the heterogeneity in results.…”

Section: Discussionmentioning

confidence: 99%

The effect of saffron supplementation on glycemic parameters: An overview of systematic reviews

Sadigi

Yarani

Mirghafourvand

et al. 2022

Phytotherapy Research

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Due to the widespread use of herbal medicine and evidence pointing to the health benefits of saffron supplementation, this review was performed to evaluate the effects of saffron supplementation on glycemic parameters and lipid profiles based on previous reviews. Relevant articles were retrieved from various databases, which included PubMed, Scopus, ProQuest, Web of Science, Embase, and Cochrane until 2020, with no date restrictions. The quality of the included reviews was assessed using the Assessment of Multiple Systematic Reviews (AMSTAR) checklist. Finally, of 877 obtained articles, eight reviews meeting the inclusion criteria were included for analysis. Among the eight included reviews, seven articles were meta-analyses. In addition, one review had an average quality while seven had a good quality. A narrative description of the included reviews was performed, while a network meta-analysis was not conducted. A brief review of the results was reported according to the weighted mean difference and mean difference. Seven included reviews assessed the effects of saffron or crocin supplementation on glycemic parameters, and six examined these effects on lipid profile parameters. Almost half of the articles reported significant effects of these supplements on glycemic parameters and lipid profiles. Taken together, results suggest that saffron supplementation may improve glycemic and lipid profile parameters; however, further high-quality studies are needed to confirm the clinical efficacy of saffron on glycemic parameters and lipid profiles

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Effect of Crocin and Voluntary Exercise on P53 Protein in Pancreas of Type2 Diabetic Rats

Cited by 17 publications

References 31 publications

Impact of chronic exercise on counteracting chronic stress-induced functional and morphological pancreatic changes in male albino rats

Impact of chronic exercise on counteracting chronic stress-induced functional and morphological pancreatic changes in male albino rats

The Effect of Crocin Supplementation on Glycemic Control, Insulin Resistance and Active AMPK Levels in Patients with Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

The effect of saffron supplementation on glycemic parameters: An overview of systematic reviews

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