Effect of Gonadotrophins on the Oestrous Cycle in the Guinea-Pig

Das, R. M.; Benson, G. K.

doi:10.1677/joe.0.0470423

Cited by 9 publications

(9 citation statements)

References 9 publications

(9 reference statements)

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“…The incidence of entrapped ova in luteinizing follicles was greatest in the group receiving the combined PMSG-HCG treatment and may represent an excessive stimulation of the follicular apparatus. This is apparently a common response of the guinea pig ovary to exogenous gonadotropin (Hamburger and Pedersen-Bjergaard, 1946;Perry and Rowlands, 1963;Deane sly, 1966;Das and Benson, 1970;Donovan and Lockhart, 1972), and suggests that further decreases in the total gonado tropin dosage may be warranted.…”

Section: Discussionmentioning

confidence: 96%

Effects of Gonadotropins on Follicular Development, Ovulation, and Atresia in the Mature Guinea Pig

Rawson¹,

Galey²,

Weinberg³

et al. 1979

Horm Res

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The induction of follicular growth, ovulation, and atresia by heterologous gonadotropic preparations was studied late in the reproductive cycle of the adult female guinea pig. Human chorionic gonadotropin (HCG) administration (10 IU) 12 days following the first signs of opening of the vaginal membrane was found to stimulate ovulation within 24 h in all animals studied, as evidenced by recovery of ova from their oviducts as well as the presence of postovulatory follicles in their ovaries. Histologically, ovaries of animals receiving HCG exhibited atretic changes in most of the follicles smaller than 999 µmin diameter. Pregnant mares serum gonadotropin (PMSG, 10 IU) administered on days 9 and 10 of the cycle was not sufficient to stimulate ovulation in this species although histological changes in the follicular complement were observed. Administration of PMSG prior to the HCG appeared to have an inhibitory effect on ovulation induction. Follicles luteinizing with entrapped ova were seen in all groups receiving exogenous gonadotropin, although they were most prevalent in the animals receiving the maximum total gonadotropin doses (i.e. PMSG + HCG).

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Section: Discussionmentioning

confidence: 96%

Effects of Gonadotropins on Follicular Development, Ovulation, and Atresia in the Mature Guinea Pig

Rawson¹,

Galey²,

Weinberg³

et al. 1979

Horm Res

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“…Das & Benson (1970) gave FSH, LH or combinations of the two hormones daily to guineapigs between days 12 and 15. With 200/ig NIH-LH-Sl 1 daily the treatment cycles were extended by 5-7f days, and with 400 µg of the hormone by 5J-9 days.…”

Section: Discussionmentioning

confidence: 99%

Growth and Regression of the Corpora Lutea Formed in Guinea-Pigs in Response to Treatment With Exogenous Gonadotrophin

Donovan¹,

Lockhart²

1972

Journal of Endocrinology

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The growth and functional activity of luteal bodies formed in the ovaries of guinea-pigs given exogenous gonadotrophin was examined. Folliclestimulating hormone, luteinizing hormone, both hormones together, and both hormones supplemented with prolactin, were given on day 13. Vaginal oestrus occurred 8-12 days later, irrespective of the kind of hormone given. The sizes of luteal bodies induced in intact and hysterectomized guinea-pigs were compared with those of similarly aged naturally formed corpora lutea 8 and 11 days after ovulation. The artificially induced bodies were smaller than normal corpora lutea, but grew to match their size after hysterectomy.

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“…Exogenous LH appears to be luteotrophic in normal cyclic guinea-pigs (Das & Benson, 1970), and Nalbandov (1961) suggested a luteotrophic role of LH in this species. Unfortunately, on the basis of tinctorial differentiation we found it difficult to distinguish with certainty between gonadotrophs and thyrotrophs, and therefore to identify FSH-and LH-secreting cells.…”

Section: Discussionmentioning

confidence: 97%

Alteration in the Oestrous Cycle Length After Pituitary Homotransplantation in the Guinea-Pig

Das¹,

Benson²

1970

Journal of Endocrinology

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Pituitaries from adult or young guinea-pigs were implanted under the kidney capsule of intact adult female guinea-pigs between the 3rd and 5th days of the oestrous cycle.The oestrous cycles in the recipients ofadult pituitaries were mostly normal in length. Seven out of nine animals engrafted with pituitaries from their own litters had a prolonged dioestrus, ranging from 8 to 16 days longer than normal, at the end of which oestrus and ovulation occurred. When the grafts contained pituitaries from one male and one female pup the cycle extension was more pronounced than when they were composed of pituitaries from two or three female pups.

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Effect of Gonadotrophins on the Oestrous Cycle in the Guinea-Pig

Cited by 9 publications

References 9 publications

Effects of Gonadotropins on Follicular Development, Ovulation, and Atresia in the Mature Guinea Pig

Effects of Gonadotropins on Follicular Development, Ovulation, and Atresia in the Mature Guinea Pig

Growth and Regression of the Corpora Lutea Formed in Guinea-Pigs in Response to Treatment With Exogenous Gonadotrophin

Alteration in the Oestrous Cycle Length After Pituitary Homotransplantation in the Guinea-Pig

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