Effect of GnRH analogs in postnatal domestic cats

Carranza, Andrea; Faya, M.; Merlo, M. Lopez; Batista, Pablo Rodrigo; Gobello, Cristina

doi:10.1016/j.theriogenology.2014.03.012

Cited by 24 publications

(39 citation statements)

References 22 publications

(40 reference statements)

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“…This supports the previous studies in which tolerance of deslorelin implantation has been reported in prepubertal cats [7] and [19]. General health of the implanted and the control animals was also monitored by recording the weekly body weights of the cats throughout the study period.…”

Section: Discussionsupporting

confidence: 89%

“…Nonsurgical contraception in the female cat is thought to be potentially a challenge, considering the unique pattern of estrous cycle in this species [2]. However, GnRH-agonists can be used for the purpose of contraception in mammals at a wide range of age and at different stages of estrous cycles [1], [3], [4], [5], [6] and [7]. Although the use of GnRH-agonist for the control of cat population may still be too expensive, cat breeders might consider it as an option to control estrus in breeding queens.…”

Section: Introductionmentioning

confidence: 99%

“…Although the absence of upregulation effect in these dogs has been attributed to their prepubertal status, there are no reports regarding the use of GnRH-agonist treatment in prepubertal female cats. Recent studies on postnatal female cats using 1.6-mg GnRH-agonist (deslorelin) found that puberty in the treated cats was delayed for 16 months and the number of primordial, primary, secondary, and antral follicles in the treated cats were significantly lower than the controls [7] and [8]. However, there is not enough information regarding how long GnRH-agonist treatment could delay puberty in prepubertal female cats.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

GnRH-agonist implants suppress reproductive function and affects ovarian LHR and FSHR expression in prepubertal female cats

et al. 2017

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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GnRH-agonist implants suppress reproductive function and affects ovarian LHR and FSHR expression in prepubertal female cats

et al. 2017

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“…In adult men and women GnRH actions are the master controller of the pituitary-gonadal axis and reproductive function. For this reason, GnRH antagonists or agonists have been used to treat failures of reproductive development and function in humans as well as in animal models (Blanchard et al, 1998;Carranza et al, 2014;Dong et al, 2011). Some of the beneficial effects of GnRH administration are coupled to the regulation of SCF levels in testicular and ovarian cells.…”

Section: Gonadotropin-releasing Hormone (Gnrh)mentioning

confidence: 99%

Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Figueira

Cardoso

Correia

et al. 2014

Progress in Histochemistry and Cytochemistry

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“…At the time of writing, none of the others, ranging in age from 13 to 63 weeks, had come into puberty (Carranza et al. ).…”

Section: Postponement Of Puberty In Female Catsmentioning

confidence: 99%

Suppression of Fertility in Pre‐pubertal Dogs and Cats

Schäfer-Somi

Kaya

Gültiken

et al. 2014

Reprod Domestic Animals

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Contents Pre‐pubertal gonadectomy in dogs and cats is still controversially discussed because some consequences cause health problems. Nevertheless, postponement of puberty, that is, prevention of an increase in sexual hormones and thereby prevention of their manifold effects, is of major importance, not only in controlling overpopulation but also to preserve the genetic base for future breeding stock and pets. Therefore, alternatives for surgical suppression of fertility in pre‐pubertal animals were critically reviewed. As a promising alternative, the slow‐release GnRH agonist deslorelin and other GnRH analogues have been investigated. In female dogs and cats, puberty could be significantly postponed without initial flare‐up effect and without disturbance of body development. First trials to delay puberty in female and male cats by application of a 4.7‐mg deslorelin implant 24 h after birth so far are promising. In female dogs, a previous investigation showed that when the implant was inserted at the age of 4 months, the initial flare‐up effect was prevented. Body development was normal in the studies reviewed here, and with the 9.4‐mg implant, puberty was significantly delayed until the age of 21 months or older. In one study, bitches either received a 4.7‐ or a 9.4‐mg implant at the age of 4 months and the epiphyses were mostly closed before the time of first oestrus. Using a 4.7‐mg deslorelin implant in pre‐pubertal male dogs significantly postponed puberty, and age at puberty was >2 years when a 9.4‐mg implant was used. However, further investigations are required, especially concerning the effect of different GnRH agonist dosages and resorption rates on the duration of postponement of puberty as well as long‐term effects in both dogs and cats.

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Effect of GnRH analogs in postnatal domestic cats

Cited by 24 publications

References 22 publications

GnRH-agonist implants suppress reproductive function and affects ovarian LHR and FSHR expression in prepubertal female cats

GnRH-agonist implants suppress reproductive function and affects ovarian LHR and FSHR expression in prepubertal female cats

Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?

Suppression of Fertility in Pre‐pubertal Dogs and Cats

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