Effect of Glyprolines PGP, GP, and PG on Homeostasis of Gastric Mucosa in Rats with Experimental Ethanol-Induced Gastric Ulcers

Falalyeyeva, Tetyana; Samonina, G. E.; Beregovaya, T. V.; Андреева, Л. А.; Dvorshchenko, E. A.

doi:10.1007/s10517-010-1028-7

Cited by 15 publications

(25 citation statements)

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“…Oligopeptides were shown to be involved in the regulation of intracellular communication processes, nociception, vessel permeability, neoangiogenesis, nervous impulse transduction as well as affect the activity of hormones and enzymes and exhibit neuro-and immunomodulatory effects [13][14][15][16][17][18][19][20][21]. It is also hypothesized that biological activity of short peptides is mainly associated with their prominent antioxidant properties, although this data is a little bit contradictory as some compounds were reported to have an opposite effect, increasing the processes of oxidation [2,8,16,[24][25][26].Due to the recent literary data, the most explored representatives of oligopeptides with gastroprotective properties are met-enkephaline (His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) [27,28] and leu-enkephaline (Tyr-Gly-Gly-Phe-Leu) [27][28][29], demorphine (Н-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH 2 ) and sedatine (H-ArgTyr-D-Ala-Phe-Gly-OH) [5,30], pentadecapeptide BPC 157 (GlyGlu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val) [10,[31][32][33]; proline-and hydroxyproline-containing products …”

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confidence: 99%

“…Thus, introduction of glyprolines caused the decrease of the area of gastric lesions induced by stress, ethanol, indomethacin and pylorus ligation [9,24,25,35,36]. It was documented that glyprolins posess not only protective untiulcer properties, but also accelerate ulcer healing [7,9,24,25,35,36,40].The most prominent untiulcer effects on all models of ulceration were evaluated in Pro-Gly-Pro and Pro-Gly-Pro-ProGly-Pro [7,24,25]. Due to the literary data the untiulcer effects of Pro-Gly, Pro-Gly-Pro, Gly-Pro-Gly-Pro and Gly-Pro-Gly-Pro-GlyPro, administered intraperitoneally, made 71%, 72%, 64% and 60% respectively; and 83%, 64%, 72% and 65% in the case of intragastral administration [7,9,24,25,35,36,40].…”

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confidence: 99%

“…It was documented that glyprolins posess not only protective untiulcer properties, but also accelerate ulcer healing [7,9,24,25,35,36,40].…”

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confidence: 99%

“…On the model of acetate-induced lesions of the gastric mucos, glyprolines were reported to decrease the severity of inflammation in the zone of ulcer defect both in the period of formation of the ulcerative defect and during healing [7,9,24,25,35,36,40]. The anti-inflammatory effect of glyprolines is proved by significant decrease of the number of polymorphonuclear leukocytes in the ulcer zone [7,9,24,25,35,36,40].Accelerating healing of the acetic acid lesions of the stomach on experimental models, glyprolines caused earlier total differentiation of the superficial epithelium and glands of the gastric mucosa, promoted the production of the large amount of fibroblasts in the place of regenerating ulcer and decreased the number of macrophages [7,9,24,25,35,36,40]. The studies conducted in rats with gastric lesions, caused by ethanol application and water-immersion restraint stress provide data that prominent preventive effect of Pro-Gly-Pro and Gly-Pro are determined by antioxidant properties of these substances [24,25].…”

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confidence: 99%

“…The anti-inflammatory effect of glyprolines is proved by significant decrease of the number of polymorphonuclear leukocytes in the ulcer zone [7,9,24,25,35,36,40].…”

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Gastroprotective Oligopeptides

Nasadyuk¹

2015

GHOA

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IntroductionPeptic ulcer disease and its complications still remain a hot issue in modern gastroenterology and one of the constantly important targets for pharmacologic research [1][2][3]. It is commonly acknowledged that nonsteroidal anti-inflammatory drugs (NSAIDs), being the most commonly prescribed group of drugs worldwide for the management of pain and inflammation, play an important role in provoking gastrointestinal tract ulceration, bleeding and perforation [1,4,5]. This mediates the necessity of the effective gastroprotective measures in patients, who are at risk of gastric ulceration, in particular chronic NSAIDs users. Nowadays for this purpose proton pump inhibitors and H 2 -antagonists are commonly used, but due to side effects of these drugs the search for new compounds with gastroprotective properties, suitable for longterm use, remains actual [1,2]. Contemporary literature gives accumulating evidence that a number of oligopeptides play an important role in the regulation of the function of gastrointestinal tract and their synthetic analogues were reported to be effective in the prevention and treatment of gastric ulceration [1,[5][6][7][8][9][10][11][12].That is why the purpose of this review was to summarize the current data on the oligopeptides with documented gastroprotective properties and their possible mechanisms of action. DiscussionDue to the modern outlook, regulatory peptides are considered to be phylogenetically the oldest form of bioregulation [13][14][15][16][17][18][19][20][21]. Thus, the mechanisms of peptidergic regulation of homeostasis open huge perspectives for the creation of the essentially new methods for the prevention and treatment of different diseases [13][14][15][16]. Interestingly, deep studies of the mechanisms of action of regulatory peptides showed that in many cases life-sustaining processes are regulated not by the total peptide molecules but their short-chained derivatives -oligopeptides that are produced in the course of limited proteolysis from proteins-precursors (cytokines, thymic peptides, immunoglobulins) [13,14,18,20,21].The term "oligopeptide" refers to proteins, composed of not more than 20 amino acid residues [22]. For example, it was shown that the inhibition of pancreatic juice secretion by 28-amino acidscontaining hormone ghrelin is realized by its biologically active part -pentapeptide with the sequence of amino acids Gly-Ser-Ser (n-octanoyl)-Phe [23].The advantages of the short peptides above their long-chain derivatives are high biological activity, that often many fold exceeds the activity of the peptide-precursor, high tissue specificity, lack of species specificity and lack of immunogenicity [13,14,[15][16][17][18]20,21]. It was established that low-weighing oligopeptides realize their effect on the cellular, chromosomal, genomic and molecular levels [13][14][15][16][17][18][19][20][21]. The interaction with DNA was proposed to be the key moment of the realization of the biological effect of the short peptides [17][18][19]21]. This concept is s...

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confidence: 99%

mentioning

confidence: 99%

“…It was documented that glyprolins posess not only protective untiulcer properties, but also accelerate ulcer healing [7,9,24,25,35,36,40].…”

mentioning

confidence: 99%

mentioning

confidence: 99%

“…The anti-inflammatory effect of glyprolines is proved by significant decrease of the number of polymorphonuclear leukocytes in the ulcer zone [7,9,24,25,35,36,40].…”

mentioning

confidence: 99%

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Gastroprotective Oligopeptides

Nasadyuk¹

2015

GHOA

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Effects of Glyprolines on DNA Synthesis and Free Radical Oxidation in Mouse Gastric Mucosa Under Physiological Conditions and During Therapy with Oral Non-Steroid Anti-Inflammatory Drugs

et al. 2015

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Studies by (3)H-thymidin autoradiography showed that injections of Pro-Gly-Pro and Arg-Gly-Pro peptides caused no changes in the DNA synthesis processes in the gastric mucosa. Both peptides induced a reduction of free radical oxidation activity, which was shown by chemiluminescence. Indomethacin induced lesions in the gastric mucosa, triggered oxidative stress, and reduced proliferative activity. Injection of Pro-Gly-Pro peptide before indomethacin corrected disorders in oxidative status and normalized DNA synthesis. Preinjection of Arg-Gly-Pro led to enlargement (by 4.6 times) of the focus of lesions in animals treated by indomethacin and augmented oxidative stress.

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