Effect of Glycyrrhizin on Estrogen Action

Kumagai, Akira; Nishino, Kazuhiko; Shimomura, Atsushi; Kin, Takekazu; Yamamura, Yuichi

doi:10.1507/endocrj1954.14.34

Cited by 35 publications

(6 citation statements)

References 6 publications

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“…Dong quai [ Angelica sinensis (Oliv.) Diels (AS)] is a common Chinese herb used for women's health, and licorice ( Glycyrrhiza glabra L.) has been reported to have both estrogenic and antiestrogenic activities ( , ). Several case reports implicate Asian ginseng [ Panax ginseng C.A.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms

Liu

Burdette

et al. 2001

J. Agric. Food Chem.

390

348

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Eight botanical preparations that are commonly used for the treatment of menopausal symptoms were tested for estrogenic activity. Methanol extracts of red clover (Trifolium pratense L.), chasteberry (Vitex agnus-castus L.), and hops (Humulus lupulus L.) showed significant competitive binding to estrogen receptors alpha (ER alpha) and beta (ER beta). With cultured Ishikawa (endometrial) cells, red clover and hops exhibited estrogenic activity as indicated by induction of alkaline phosphatase (AP) activity and up-regulation of progesterone receptor (PR) mRNA. Chasteberry also stimulated PR expression, but no induction of AP activity was observed. In S30 breast cancer cells, pS2 (presenelin-2), another estrogen-inducible gene, was up-regulated in the presence of red clover, hops, and chasteberry. Interestingly, extracts of Asian ginseng (Panax ginseng C.A. Meyer) and North American ginseng (Panax quinquefolius L.) induced pS2 mRNA expression in S30 cells, but no significant ER binding affinity, AP induction, or PR expression was noted in Ishikawa cells. Dong quai [Angelica sinensis (Oliv.) Diels] and licorice (Glycyrrhiza glabra L.) showed only weak ER binding and PR and pS2 mRNA induction. Black cohosh [Cimicifuga racemosa (L.) Nutt.] showed no activity in any of the above in vitro assays. Bioassay-guided isolation utilizing ER competitive binding as a monitor and screening using ultrafiltration LC-MS revealed that genistein was the most active component of red clover. Consistent with this observation, genistein was found to be the most effective of four red clover isoflavones tested in the above in vitro assays. Therefore, estrogenic components of plant extracts can be identified using assays for estrogenic activity along with screening and identification of the active components using ultrafiltration LC-MS. These data suggest a potential use for some dietary supplements, ingested by human beings, in the treatment of menopausal symptoms.

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Section: Introductionmentioning

confidence: 99%

Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms

Liu

Burdette

et al. 2001

J. Agric. Food Chem.

390

348

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“…At highdose ratios, reduced inhibition or an additive effect was observed. 121 More recently, glabridin was shown to increase uterine weight in female rats. 120 Both glabridin 120 and glabrene 118 induced the activity of creatine kinase, an immediate early estrogen-induced protein, in the rat model.…”

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confidence: 99%

Phytoestrogens in Botanical Dietary Supplements: Implications for Cancer

Piersen¹

2003

Integr Cancer Ther

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Phytoestrogens are plant constituents that possess either estrogenic or antiestrogenic activity. Although their activities are weak as compared with human endogenous estrogens, the consumption of phytoestrogens may have clinically significant consequences. A number of botanicals, or the compounds contained therein, have been identified as putative estrogenic agents, but consensus in the biomedical community has been hampered by conflicting data from various in vitro and in vivo models of estrogenic activity. Phytoestrogens may serve as chemopreventive agents while at the same time being capable of promoting growth in estrogen receptor positive cancer cell lines. Furthermore, they may exert their estrogenic influence through receptor-dependent and/or receptor-independent mechanisms. These findings have led to speculation that phytoestrogen intake might be ill advised for patients at an increased risk for hormone-dependent cancers, cancer patients, or cancer survivors. This article will attempt to sort out discrepancies between various experimental models and establish whether certain herbs possess estrogenic activity. The review will focus on 5 popular botanical dietary supplements: Trifolium pratense (red clover), Cimicifuga racemosa (black cohosh), Humulus lupulus (hops), Angelica sinensis (dong quai), and Glycyrrhiza glabra (licorice). It will address their mechanisms of action, clinical evidence bases, and implications for use in cancer.

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“…Estrogen stimulates cell proliferation in the endometrium, which leads to endometrial hyperplasia and increases the risk of developing cancer [79] . GL has been shown to have anti-estrogenic effects in mice and rats at dose ratios of 500:1 and 1000:1 of glycyrrhizin:estradiol-17β, suggesting that it may exert its chemopreventive effects by acting on the estrogen receptor [80] . There is also evidence that treatment of ovariectomized mice on an estrogen-containing diet with GL significantly reduced the expression of COX-2 mRNA in their uteri compared to mice that were fed the estrogen-containing diet without any additional treatment [78] .…”

Section: Anticancer Mechanisms Of Action Of Licorice Triterpenoidsmentioning

confidence: 99%

Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights

Jain

Hussein

Pierce

et al. 2022

Pharmacological Research

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Effect of Glycyrrhizin on Estrogen Action

Cited by 35 publications

References 6 publications

Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms

Evaluation of Estrogenic Activity of Plant Extracts for the Potential Treatment of Menopausal Symptoms

Phytoestrogens in Botanical Dietary Supplements: Implications for Cancer

Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights

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