2022
DOI: 10.1016/j.phrs.2022.106138
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Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights

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Cited by 47 publications
(27 citation statements)
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“…Licorice is composed of more than 20 triterpenoids and nearly 300 flavonoids, with the key active constituents being glycyrrhizin, glycyrrhetinic acid, licochalcone A, licochalcone E, glabridin, and liquiritigenin [ 25 , 26 ] ( Table 2 ). The licorice triterpenoid glycyrrhizin and its derivatives have been studied for their potential oncopreventive and oncotherapeutic functions [ 27 ]. On the contrary, it is also known that the chronic use of licorice may induce nephrotoxicity, which causes hypertension by inducing a hyper-mineralocorticoid state to suppress the renin-angiotensin system, possibly due to its glycyrrhetinic acid content [ 28 ].…”
Section: Licorice (Glycyrrhiza Radix)mentioning
confidence: 99%
“…Licorice is composed of more than 20 triterpenoids and nearly 300 flavonoids, with the key active constituents being glycyrrhizin, glycyrrhetinic acid, licochalcone A, licochalcone E, glabridin, and liquiritigenin [ 25 , 26 ] ( Table 2 ). The licorice triterpenoid glycyrrhizin and its derivatives have been studied for their potential oncopreventive and oncotherapeutic functions [ 27 ]. On the contrary, it is also known that the chronic use of licorice may induce nephrotoxicity, which causes hypertension by inducing a hyper-mineralocorticoid state to suppress the renin-angiotensin system, possibly due to its glycyrrhetinic acid content [ 28 ].…”
Section: Licorice (Glycyrrhiza Radix)mentioning
confidence: 99%
“…Compounds isolated from licorice have a pronounced anti-inflammatory effect. Studies show that licorice inhibits toll-like receptor 4 (TLR4) activation, mitogen-activated protein kinase (MAPK) signaling pathway, nuclear factor kappa B (NF-κB) expression, and activator protein (AP)-1 transcriptional activity, which subsequently leads to a decrease in the expression of pro-inflammatory cytokines and chemokines and other inflammatory mediators such as COX-2, inducible nitric oxide synthase (iNOS), TNF-α, IL-6, IL-1β, IL-12, and IL-23 and vascular endothelial growth factor (VEGF) [ 29 , 30 , 31 , 32 , 33 , 34 ]. It was shown that an intravenous injection of glycyrrhizin inhibited the expression of TLR-4 in BALB/c mice after intraperitoneal administration of LPS as well as a significantly decreased protein content, inflammatory cell counts, TNF-α, IL-1α, IL-6, myeloperoxidase activity, and expressions of COX-2iNOS, and NF-κB [ 35 ].…”
Section: Anti-inflammatory Properties Of G Glabramentioning
confidence: 99%
“…Збільшена продукція активних форм кисню та азоту, зниження активності антиоксидантних ферментів та вичерпання неферментативних антиоксидантів призводить до розвитку оксидативного ушкодження біологічних полімерів в клітині (ДНК, РНК, клітинна мембрана, білкові молекули, тощо). Оксидативне ушкодження біологічних полімерів (оксидативний стресс) лежить в основі багатьох патологій, які опосередковуються такими типовими патологічними процесами як запалення, пухлинний ріст, тощо [7,8]. Також розвиток оксидативного стресу може бути пов'язаний із порушенням внутрішньоклітинної сигналізаці внаслідок надмірної активації або інгібіції редокс-чутливих транскрипційних факторів, таких як NF-kB [9].…”
Section: примітка: л -кількість лекційних годин; п -кількість практич...unclassified