Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights

Jain, Rifika; Hussein, Mohamed Ali; Pierce, Shannon; Martens, C. P.; Shahagadkar, Preksha; Munirathinam, Gnanasekar

doi:10.1016/j.phrs.2022.106138

Cited by 47 publications

(27 citation statements)

References 172 publications

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“…Licorice is composed of more than 20 triterpenoids and nearly 300 flavonoids, with the key active constituents being glycyrrhizin, glycyrrhetinic acid, licochalcone A, licochalcone E, glabridin, and liquiritigenin [ 25 , 26 ] ( Table 2 ). The licorice triterpenoid glycyrrhizin and its derivatives have been studied for their potential oncopreventive and oncotherapeutic functions [ 27 ]. On the contrary, it is also known that the chronic use of licorice may induce nephrotoxicity, which causes hypertension by inducing a hyper-mineralocorticoid state to suppress the renin-angiotensin system, possibly due to its glycyrrhetinic acid content [ 28 ].…”

Section: Licorice (Glycyrrhiza Radix)mentioning

confidence: 99%

Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator

Zhang

Yung

2022

Antioxidants

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Oxidative stress could lead to a variety of body dysfunctions, including neurodegeneration and cancer, which are closely associated with intracellular signal transducers such as reactive oxygen species (ROS). It has been suggested that ROS is the upstream regulator of autophagy, and that it provides a negative feedback regulation to remove oxidative damage. Defects in the ROS-autophagic redox homeostasis could lead to the increased production of ROS and the accumulation of damaged organelles that in turn promote metabolic reprogramming and induce tumorigenesis. One significant characteristic of pancreatic cancer is the reprogramming of cellular energy metabolism, which facilitates the rapid growth, invasiveness, and the survival of cancer cells. Thus, the rectification of metabolic dysfunction is essential in therapeutic cancer targeting. Isoliquiritigenin (ISL) is a chalcone obtained from the plant Glycyrrhiza glabra, which is a powdered root licorice that has been consumed for centuries in different regions of the world. ISL is known to be a natural antioxidant that possesses diversified functions, including redox regulation in cells. This review contains discussions on the herbal source, biological properties, and anticancer potential of ISL. This is the first time that the anticancer activities of ISL in pancreatic cancer has been elucidated, with a coverage of the involvement of antioxidation, metabolic redox regulation, and autophagy in pancreatic cancer development. Furthermore, some remarks on related compounds of the isoflavonoid biosynthetic pathway of ISL will also be discussed.

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Section: Licorice (Glycyrrhiza Radix)mentioning

confidence: 99%

Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator

Zhang

Yung

2022

Antioxidants

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“…Compounds isolated from licorice have a pronounced anti-inflammatory effect. Studies show that licorice inhibits toll-like receptor 4 (TLR4) activation, mitogen-activated protein kinase (MAPK) signaling pathway, nuclear factor kappa B (NF-κB) expression, and activator protein (AP)-1 transcriptional activity, which subsequently leads to a decrease in the expression of pro-inflammatory cytokines and chemokines and other inflammatory mediators such as COX-2, inducible nitric oxide synthase (iNOS), TNF-α, IL-6, IL-1β, IL-12, and IL-23 and vascular endothelial growth factor (VEGF) [ 29 , 30 , 31 , 32 , 33 , 34 ]. It was shown that an intravenous injection of glycyrrhizin inhibited the expression of TLR-4 in BALB/c mice after intraperitoneal administration of LPS as well as a significantly decreased protein content, inflammatory cell counts, TNF-α, IL-1α, IL-6, myeloperoxidase activity, and expressions of COX-2iNOS, and NF-κB [ 35 ].…”

Section: Anti-inflammatory Properties Of G Glabramentioning

confidence: 99%

Atheroprotective Effects of Glycyrrhiza glabra L.

et al. 2022

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Cardiovascular diseases associated with atherosclerosis are the major cause of death in developed countries. Early prevention and treatment of atherosclerosis are considered to be an important aspect of the therapy of cardiovascular disease. Preparations based on natural products affect the main pathogenetic steps of atherogenesis, and so represent a perspective for the long-term prevention of atherosclerosis development. Numerous experimental and clinical studies have demonstrated the multiple beneficial effects of licorice and its bioactive compounds—anti-inflammatory, anti-cytokine, antioxidant, anti-atherogenic, and anti-platelet action—which allow us to consider licorice as a promising atheroprotective agent. In this review, we summarized the current knowledge on the licorice anti-atherosclerotic mechanisms of action based on the results of experimental studies, including the results of the in vitro study demonstrating licorice effect on the ability of blood serum to reduce intracellular cholesterol accumulation in cultured macrophages, and presented the results of clinical studies confirming the ameliorating activity of licorice in regard to traditional cardiovascular risk factors as well as the direct anti-atherosclerotic effect of licorice.

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“…Збільшена продукція активних форм кисню та азоту, зниження активності антиоксидантних ферментів та вичерпання неферментативних антиоксидантів призводить до розвитку оксидативного ушкодження біологічних полімерів в клітині (ДНК, РНК, клітинна мембрана, білкові молекули, тощо). Оксидативне ушкодження біологічних полімерів (оксидативний стресс) лежить в основі багатьох патологій, які опосередковуються такими типовими патологічними процесами як запалення, пухлинний ріст, тощо [7,8]. Також розвиток оксидативного стресу може бути пов'язаний із порушенням внутрішньоклітинної сигналізаці внаслідок надмірної активації або інгібіції редокс-чутливих транскрипційних факторів, таких як NF-kB [9].…”

Section: примітка: л -кількість лекційних годин; п -кількість практич...unclassified

Refleсtions on Implementing Elective Course in Molecular Pathology Into the Educational Program for Master’s Degree Students

Akimov¹

2022

Act. Probl. of the Modern Med.

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Currently, the training of Master’s degree students in the specialty 222 “Medicine” does not provide the wide coverage of the molecular mechanisms of cellular disorders that would allow the students to get deeper understanding of modern approaches to the pathogenetic therapy of many diseases including type II diabetes mellitus, metabolic syndrome, coronary heart disease, etc. The curriculum of the mandatory component “Pathophysiology” implies the coverage of the above mentioned diseases and pathological conditions, however, because of the voluminous material the students need to assimilate, the course can not offer deeper insight into the molecular mechanisms of diseases and conditions. This article highlights the theoretical grounds for implementing the elective course “Molecular Pathology” into the training program for Master’s degree students in Medicine. The total workload of the elective course “Molecular Pathology” should not exceed 120 hours (4.0 ECTS credits). The study of the course can be divided into 2 modules of 60 hours each (2.0 ECTS credits): Module 1 “Pathophysiology of the cell” and Module 2 “Molecular mechanisms of the development of systemic pathologies”. Module 1 of the course “Molecular Pathology” is designed to promote the development of the following competencies including the ability to determine pathological changes in the cell during typical pathological processes; to assess the functional state of the antioxidant system of the body; to develop pathogenetically substantiated correction of oxidative damage to the body. Module 2 is elaborated to provide applicants with an opportunity to acquire the following competencies: analysis of the effect of cytokines on the development of typical pathologies in various organs and systems; make up a customized plan for pathogenetic therapy of patients with impaired insulin signalling; assessment of the functional state of the circadian oscillator system of the body. The implementation of the elective course of molecular pathology into the training program for Master’s medical students ensures the better understanding of pathological body processes, contributes to the high-quality education as well as increases the competitiveness of future specialists.

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Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights

Cited by 47 publications

References 172 publications

Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator

Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator

Atheroprotective Effects of Glycyrrhiza glabra L.

Refleсtions on Implementing Elective Course in Molecular Pathology Into the Educational Program for Master’s Degree Students

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