Effect of Glycemic Control on Left Ventricular Diastolic Function in Type 1 Diabetes Mellitus

Grandi, Anna Maria; Piantanida, Eliana; Franzetti, Ivano; Bernasconi, Mara; Maresca, Andrea Maria; Marnini, P; Guasti, Luigina; Venco, Achille

doi:10.1016/j.amjcard.2005.07.110

Cited by 63 publications

(45 citation statements)

References 21 publications

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“…These findings are in agreement with previous observations by other authors and ourselves, since left atrium dimensions had been found related to hypertension associated to metabolic abnormalities 29 and impairment of the diastolic function had been observed in subjects with increased insulin resistance 30 as well as in diabetic patients. 31 Moreover, these findings also confirm that myocardial dysfunction increases according to the number of risk factors: 32 in the case of MS there are at least three concomitant cardiovascular risk factors.…”

Section: Discussionsupporting

confidence: 66%

Cardiac structure and function and arterial circulation in hypertensive patients with and without metabolic syndrome

et al. 2007

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High blood pressure (BP) is one of the crucial determinants of the metabolic syndrome (MS). The extent to which MS, diagnosed according to the criteria of the International Federation of Diabetes, impacts on cardiovascular organ damage, independently of BP, is debated. Three hundred and forty hypertensive patients and 100 normotensive controls underwent the following procedures: (1) physical examination and resting BP measurements, (2) 24 h ambulatory BP monitoring, (3) laboratory routine examination, (4) echocardiography, (5) carotid ultrasonography and (6) ankle-brachial BP index. The syndrome was found in 104 of the 340 hypertensive patients (30.6). In comparison to those without MS, those with MS had significantly higher prevalence of left ventricular (LV) hypertrophy by mass/height 2.7 criteria (46 vs 42%, Po0.01) but not by LV mass/body surface criteria (30 vs 31%); the ratio between early-to-late peak velocities of the LV filling waves (E/A) was higher (E/ A ¼ 0.9970.14 vs 0.8970.15, Po0.01) and left atrium was larger (3.870.3 vs 3.570.5 cm, Po0.01). Both hypertensive groups had significantly greater LVM and carotid intima-media thickness than normotensives, without between-group-difference. In this hypertension outpatient clinic almost one-third hypertensive patients have MS. They show a deterioration in structure and function of the heart in comparison to hypertensive patients without MS, but no difference was detected in the carotid and peripheral arterial circulation.

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Section: Discussionsupporting

confidence: 66%

Cardiac structure and function and arterial circulation in hypertensive patients with and without metabolic syndrome

et al. 2007

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“…This was in accordance with Fiorina, who demonstrated that glycemic levels had an impact on diastolic dysfunction (Fiorina, 2000). There was one study done by Ann m. Grandi et al, showed a close relationship between glycemic control and left ventricular diastolic dysfunction in 36 type 1 diabetic patients, which improved with glycemic control (Grandi, 2006). It was also noted that normal body mass index could be due to the racial and dietary factors, which is different between the South East Asian population and the Caucasian and the Black population.…”

Section: Discussionsupporting

confidence: 67%

Asymptomatic Left Ventricular Diastolic Dysfunction in Niddm; Evaluation and Association with Glycemic Control

Kashif¹,

Ali²,

Hakim³

et al. 2016

Int. j. endorsing health sci. res.

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DM is an established risk factor for congestive cardiac failure, in which the diastolic function is impaired. The majority of these patients may be asymptomatic without signs of overt heart failure. The aim of this study was to determine asymptomatic Left Ventricular Diastolic Dysfuction (LVDD) in Non-Insulin Dependent Diabetes Mellitus (NIDDM) in association with glycemic control and to assess the risk factors for the development of diastolic dysfunction. This cross sectional study was conducted at the Tabba Heart Institute, Karachi from Dec, 2011 to Nov 2012, 101 asymptomatic patients with type 2 diabetes without evidence of cardio-respiratory illness were enrolled. LVDD was evaluated by Doppler echocardiography, which included the valsalva manoeuvre. A total of 101 patients, LVDD was found in 67 subjects (66.34%) of whom 52 (51.48%) had impaired relaxation and 15 (14.85%) had a pseudonormal pattern of ventricular filling. The potential risk factors for the development of LVDD in type 2 diabetics were (a) age ≥45 years was associated with an almost three times higher risk for LVDD, (b) females had almost two times a higher risk of LVDD as compared with men, and (c) Diabetic patients of more than two years' duration had a two times higher risk of LVDD. The study results also indicate that LVDD was significantly associated with increased age, longer duration of Diabetes and glycemic control (glycated HbA1c levels) and LVDD is found in diabetic patients before the onset of clinically detectable disease. The high prevalence of LVDD suggests that screening for LVDD should include procedures such as the valsalva manoeuvre.

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“…16,39,[126][127][128][129][130][131][132] The extent of atherosclerosis by intravascular ultrasound also correlated with HbA 1c over 18 years of follow-up in the Oslo Study; a 1% increase in mean HbA 1c was associated with a 6.4% increase in coronary vessel stenosis. 78 Intensive DM therapy has been shown to prevent the increase in resting heart rate characteristic of patients with T1DM, 133 and autonomic function was significantly better in patients with intensive DM management.…”

Section: Glycemic Controlmentioning

confidence: 91%

Type 1 Diabetes Mellitus and Cardiovascular Disease

Ferranti¹,

Boer²,

Fonseca³

et al. 2014

Circulation

300

126

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Effect of Glycemic Control on Left Ventricular Diastolic Function in Type 1 Diabetes Mellitus

Cited by 63 publications

References 21 publications

Cardiac structure and function and arterial circulation in hypertensive patients with and without metabolic syndrome

Cardiac structure and function and arterial circulation in hypertensive patients with and without metabolic syndrome

Asymptomatic Left Ventricular Diastolic Dysfunction in Niddm; Evaluation and Association with Glycemic Control

Type 1 Diabetes Mellitus and Cardiovascular Disease

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