Effect of Glucose Diuresis on Renal Excretion of Bicarbonate.

Goodyer, Allan V. N.; Welt, Louis G.; Darragh, James H.; Abele, William A.; Meroney, William H.

doi:10.3181/00379727-86-20999

Cited by 2 publications

(2 citation statements)

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“…A similar effect has been shown with urea (2). While not previously investigated in the dog, glucose, another osmotic agent, increases bicarbonate reabsorption in man (3). This may not be a unique effect of glucose since mannitol also increases hydrogen ion secretion in man (4).…”

Section: Introductionsupporting

confidence: 48%

Effects of Glucose on Bicarbonate Reabsorption in the Dog Kidney

Suki¹,

Herbert²,

Stinebaugh³

et al. 1974

J. Clin. Invest.

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Section: Introductionsupporting

confidence: 48%

Effects of Glucose on Bicarbonate Reabsorption in the Dog Kidney

Suki¹,

Herbert²,

Stinebaugh³

et al. 1974

J. Clin. Invest.

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“…During mannitol diu-resis there is a progressive linear increase in the bicarbonate concentration of the reabsorbate as urine flow increases, whereas following chloride loading in most of our experiments there is a fall in the bicarbonate concentration of the reabsorbate as urine flow increases. Since it has also been shown that osmotic diuresis per se does not particularly increase the excretion of bicarbonate (13,14) it is apparent that the increases in the excretion of bicarbonate and decreases in the reabsorption of bicarbonate following chloride loading are brought about by some other mechanism.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Acute Elevation of the Plasma Chloride Concentration on the Renal Excretion of Bicarbonate During Acute Respiratory Acidosis 1

Hilton¹,

Capeci²,

Kiss³

et al. 1956

J. Clin. Invest.

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It has been postulated recently that renal bicarbonate reabsorption is entirely dependent on the exchange of hydrogen ions, derived from the dissociation of carbonic acid within the cells of the renal tubule, for the fixed base of filtered bicarbonate in the tubular urine (1-3). According to this theory, an elevation of the CO2 tension of the extracellular fluid results in an increase in the rate of bicarbonate reabsorption because it leads to an increase in the rate of hydrogen ion secretion.Earlier studies, however, indicate that chloride reabsorption may interfere with bicarbonate reabsorption presumably because of competition between these two ions for some common transport mechanism in the proximal tubule (4). Since plasma pCO2 was apparently within normal range in those experiments, it was thought of interest to study the effect of hyperchloremia on bicarbonate reabsorption in the presence of an elevated extracellular pCO2.Our results indicate that under these circumstances the rate of bicarbonate reabsorption does not depend entirely on the CO2 tension, but may, in part, depend upon the rate of chloride ion reabsorption. METHODSNormal adult mongrel female dogs were anesthetized by the intravenous administration of 0.46 to 0.62 mg. of sodium pentobarbital per kilogram of body weight. The trachea was cannulated with a "Y"-shaped glass tube, the two free arms of which served as inspiratory and expiratory airways by means of flutter valves. The animals breathed spontaneously throughout the entire experiment. The abdomen was opened by a midline in-1 Supported by grants-in-aid from the New York Heart Association and the American Heart Association.2Fellow of the New York Heart Association.3 Frances H. Zabriskie Fellow, St. Luke's Hospital.cision and each ureter cannulated with a polyethylene tube. The abdomen was then closed by a continuous silk suture and the polyethylene tubes brought through the suture line, care being taken not to kink the ureters and tubes. Urine was collected directly under mineral oil contained in a graduated cylinder.During the successive periods of study, the dog breathed first room air, then a mixture of CO, and air containing 10 per cent of CO,,The different solutions were administered at desired rates by means of a constant-speed Bowman pump via a cannulated brachial vein. As the operative procedure was begun, the animal was given intravenously within a 5 to 24-minute period 400 ml. of a 0.15 molar sodium bicarbonate solution containing 0.375 Gram per cent of creatinine. Then a sustaining infusion containing from 0.93 Gram per cent of NaHCO, to 1.175 Gram per cent of NaHCO, (0.11 to 0.14 molar solution) was administered at rates varying between 6.4 and 18.5 ml. per minute. This infusion also contained an amount of creatinine such that the dog received 15 mgm. of creatinine per minute. When the operative procedures were completed, a fifteen to thirty-minute equilibration period was allowed. Then control determinations were made, the animal breathing room air and receiving the sustaini...

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Effect of Glucose Diuresis on Renal Excretion of Bicarbonate.

Cited by 2 publications

References 0 publications

Effects of Glucose on Bicarbonate Reabsorption in the Dog Kidney

Effects of Glucose on Bicarbonate Reabsorption in the Dog Kidney

The Effect of Acute Elevation of the Plasma Chloride Concentration on the Renal Excretion of Bicarbonate During Acute Respiratory Acidosis 1

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