Effects of Glucose on Bicarbonate Reabsorption in the Dog Kidney

Suki, Wadi N.; Herbert, Charles; Stinebaugh, Bobby J.; Martinez-Maldonado, M.; Eknoyan, Garabed

doi:10.1172/jci107730

Cited by 12 publications

(4 citation statements)

References 25 publications

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“…In view of the differences in perfusate composition mentioned above, this suggestion might be particularly pertinent in explaining quantitative differences between their results and those of the present study. Thus, it has been shown (Suki, Hebert, Stinebaugh, Martinez-Maldano & Eknoyan, 1974;Wen, 1976) that glucose and anion transports may be interrelated in the proximal tubule. An additional explanation of differences between these studies may arise from the suggestion originally proposed by Walker et al (1941), and subsequently confirmed (Seely, 1973;Lingard, Rumrich & Young, 1973;Fr6mter & Gessner, 1974;Jacobson & Kokko, 1976) Collecting all the available information from the present study and from the literature, we consider it probable that the reductions in mean sodium flux in the glucose-phlorizin and saline series are real effects, albeit not statistically significant, and that there does exist a linkage between glucose and sodium reabsorption.…”

Section: Discussionmentioning

confidence: 99%

Effects of glucose on water and sodium reabsorption in the proximal convoluted tubule of rat kidney.

Bishop¹,

Green²,

Thomas³

1978

The Journal of Physiology

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SUMMARY1. The effects of glucose on sodium and water reabsorption by rat renal proximal tubules was investigated by in situ microperfusion of segments of proximal tubules with solutions containing glucose or no glucose, with and without phlorizin.2. Absence of glucose did not significantly alter net water flux. Sodium flux was reduced by about 10 % but this was not statistically significant.3. In the absence of glucose in the perfusion fluid net secretion of glucose occurred. 4. Phlorizin reduced either net reabsorption or net secretion of glucose; and net water flux.5. The data suggest that in later parts of the proximal convoluted tubule some sodium may be co-transported with glucose, but that this represents only a small fraction of the total sodium reabsorption.6. It is suggested that the glucose carrier is reversible and in appropriate circumstances could cause glucose secretion.7. Althoughphlorizin alters net water flux the underlying mechanisms are not clear. 8. The calculated osmolality of the reabsorbate was significantly greater than the perfusate osmolality and greater than plasma osmolality although this was not quite significant statistically.

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Section: Discussionmentioning

confidence: 99%

Effects of glucose on water and sodium reabsorption in the proximal convoluted tubule of rat kidney.

Bishop¹,

Green²,

Thomas³

1978

The Journal of Physiology

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“…Those studies, however, do not permit a differentiation between the effects of glucose delivered by the peritubular capillaries from the effects of glucose within the tubular lumen. A specific effect of glucose on renal ion transport has also been proposed from studies in which, following the administration of glucose, there is enhanced tubular reabsorption of bicarbonate (17); reduced tubular reabsorption of calcium (10); and, in starving patients, increased reabsorption of sodium (13). These observations, however, have not been adequately explained.…”

Section: Discussionmentioning

confidence: 99%

“…capable of net water and electrolyte transport, a specific effect of D-glucose on these transport processes has been suggested (7,8,11,14,18). Indirect evidence has also been advanced for a specific effect of n-glucose on electrolyte and water transport in the kidney of the rat, dog, and man (7, 10, 13, 17,18). The current studies were designed to directly examine the effect of n-glucose within the tubular lumen on water reabsorption from the proximal convoluted tubule of the rat kidney.…”

mentioning

confidence: 99%

D-Glucose enhancement of water reabsorption in proximal tubule of the rat kidney

Weinman¹,

Suki²,

Eknoyan³

1976

American Journal of Physiology-Legacy Content

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Water reabsorption in the proximal convoluted tubule of the rat kidney was examined by in vivo microperfusion techniques in order to examine the effect of D-glucose within the tubular lumen. When tubules were perfused with a balanced artificial solution containing Na, K, Cl, HCO3, urea, and D-glucose, absolute reabsorption averaged 4.01 +/- 0.24 nl/min per mm. Addition of D-glucose to the NaCl perfusate enhanced water reabsorption to values similar to those obtained with the balanced artificial perfusate. The enhanced water reabsorption consequent to the addition of D-glucose to the NaCl perfusion solution was completely inhibited by addition of phloridzin to the perfusate. The addition of an unabsorbed hexose, 2-deoxy-D-glucose, to the NaCl perfusate failed to enhance water reabsorption, whereas the addition of an incompletely reabsorbed sugar that is not metabolized, 3-O-methyl-D-glucose, resulted in partial enhancement of theabsolute rate of water reabsorption. These studies demonstrate that D-glucose has the specific effect of augmenting water reabsorption in the proximal tubule of the rat kidney.

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“…Methods for Na2 * 4, K+, inulin and phosphorus in the plasma and urine were described previously [3], Chloride was measured in a Cotlove Chloridometer (Buchler Instruments Div., Nuclear-Chicago Corp., Fort Lee, N.J.). Glomerular filtration rate (GFR) was determined by inulin clearance.…”

Section: Methodsmentioning

confidence: 99%

Disequilibrium pH and Bicarbonate Reabsorption

Stinebaugh

Ghafary

Goldstein

et al. 1978

Nephron

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An augmented renal capacity to reabsorb bicarbonate (RHCO^-₃) has been noted in patients with distal renal tubular acidosis (dRTA), and construed as evidence that the basic defect in dRTA is abnormal distal tubular permeability. According to this interpretation, the absence of a disequilibrium pH due to a back-leak of H₂CO₃ permits increased distal H+ secretion and results in an increased RHCO^-₃. To test this assumption, we have evaluated the effect of acute elimination of the disequilibrium pH by carbonic anhydrase infusion. The results establish that this maneuver does not cause a rise in RHCO^-₃. Thus, the elevated value for RHCO^-₃ described in dRTA cannot be the consequence of increased back-diffusion of H₂CO₃, and is more likely due to coexisting extracellular volume depletion and/or potassium deficiency.

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Effects of Glucose on Bicarbonate Reabsorption in the Dog Kidney

Cited by 12 publications

References 25 publications

Effects of glucose on water and sodium reabsorption in the proximal convoluted tubule of rat kidney.

Effects of glucose on water and sodium reabsorption in the proximal convoluted tubule of rat kidney.

D-Glucose enhancement of water reabsorption in proximal tubule of the rat kidney

Disequilibrium pH and Bicarbonate Reabsorption

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