Effect of Glucocorticoids on Athletic Performance: A Systematic Review and Meta-Analysis

Trinh, Kien; Chen, Kevin Jia Qi; Diep, Dion

doi:10.1097/jsm.0000000000000911

Cited by 4 publications

(1 citation statement)

References 22 publications

(124 reference statements)

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“…Depending on sport‐specific variables and amounts of glucocorticoids used, a growing body of evidence supports the position that this drug class indeed possesses the potential to enhance athletic performance. At the same time, glucocorticoids can cause harm to health in athletes, 108 and in consideration of a substantial amount of scientific and medical data, substance‐specific laboratory reporting levels as well as guidance as to washout periods following permissive and therapeutic drug use were presented in a comprehensive review by Ventura et al 105 A concept was created and applied where the upper range of the normal physiological daily cortisol production (26.4 mg) plus a 20% margin was taken into consideration, above which the cortisol‐equivalent resulting from synthetic glucocorticoid intake yields a continuum of increasing risk for performance enhancement. By means of published administration study data, reporting levels ranging from 15 to 300 ng/ml were suggested.…”

Section: Glucocorticoids and Cannabinoidsmentioning

confidence: 99%

Annual banned‐substance review: Analytical approaches in human sports drug testing 2020/2021

Thevis

Kuuranne

Geyer

2021

Drug Testing and Analysis

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Most core areas of anti‐doping research exploit and rely on analytical chemistry, applied to studies aiming at further improving the test methods' analytical sensitivity, the assays' comprehensiveness, the interpretation of metabolic profiles and patterns, but also at facilitating the differentiation of natural/endogenous substances from structurally identical but synthetically derived compounds and comprehending the athlete's exposome. Further, a continuously growing number of advantages of complementary matrices such as dried blood spots have been identified and transferred from research to sports drug testing routine applications, with an overall gain of valuable additions to the anti‐doping field. In this edition of the annual banned‐substance review, literature on recent developments in anti‐doping published between October 2020 and September 2021 is summarized and discussed, particularly focusing on human doping controls and potential applications of new testing strategies to substances and methods of doping specified in the World Anti‐Doping Agency's 2021 Prohibited List.

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Section: Glucocorticoids and Cannabinoidsmentioning

confidence: 99%