Effect of glass composition on the degradation properties and ion release characteristics of phosphate glass—polycaprolactone composites

Prabhakar, Roopa; Brocchini, Steve; Knowles, Jonathan C.

doi:10.1016/j.biomaterials.2004.07.016

Cited by 59 publications

(55 citation statements)

References 25 publications

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“…Young's modulus of PCL film increased gradually during incubation, while all composite films showed reduction in E t . Increase in stiffness of PCL film can be attributed to an increase in degree of crystallinity [30,31]. In the case of A2-PCL composites, the biggest changes in E t were noted in the first 3 months, and then, the values stayed on similar level until the end of the test.…”

Section: In Vitro Degradationmentioning

confidence: 73%

“…It was previously shown that the smaller particles of bioactive glass, incorporated into poly(e-caprolactone-co-DL-lactide) matrix, significantly enhanced the water absorption compared to larger particles, resulting in faster loss of polymer molecular weight [9]. In the literature, there are several works indicating that the chemical composition of resorbable phosphate glasses significantly affects degradation of PCL matrix [31,51]. Phosphate glass fillers, depending on formulation, dissolve in different rate, creating voids and channels within the polymer matrix, affecting water absorption, and therefore polymer degradation.…”

Section: In Vitro Degradationmentioning

confidence: 99%

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A new insight into in vitro behaviour of poly(ε-caprolactone)/bioactive glass composites in biologically related fluids

et al. 2017

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In the present work, the role of content, size and chemical composition of gel-derived bioactive glass particles from the SiO 2 -CaO-P 2 O 5 system in modulating the in vitro bioactivity, osteoinductive properties and long-term (up to 15 months) degradation behaviour of poly(e-caprolactone)-based composite films was investigated. Bioactivity was assessed in simulated body fluid (SBF) and HEPES-free Dulbecco's modified Eagle medium (DMEM) supplemented with 10% foetal bovine serum (FBS), while hydrolytic degradation tests were performed in phosphate buffer saline. Obtained composite films showed excellent calcium phosphate (CaP) layer forming ability in both SBF and DMEM-10% FBS. However, kinetics of bioactivity process strongly depended on the type of medium used. The layer of amino acids and proteins, derived from cell culture medium, on the surfaces of composites created barrier that inhibited release of the ions on the one hand, while increasing nucleation density of calcium phosphates, affecting the morphology of formed CaP layers on the other. The presence of bioactive glass fillers was shown to impart osteoinductive properties to obtained films, supporting osteoblast attachment and proliferation, as well as stimulating cell differentiation and also matrix mineralization process in vitro. We showed that kinetics of bioactivity process and also osteoinductive properties of composite films could be easily modulated with the use of different contents and chemical compositions of fillers. The results showed that modification of PCL matrix with bioactive glass particles accelerated its degradation. We proved that the degradation rate of composites could be controlled and optimized for bone regeneration, in particular by using bioactive fillers causing different calcium phosphate layer forming ability on the surfaces of composites, depending on particle size and chemical composition. We have presented new opportunities to design and obtain multifunctional composites with tunable degradation and bioactivity kinetics, as well as biological properties that can meet complex requirements of bone tissue engineering.

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Section: In Vitro Degradationmentioning

confidence: 73%

Section: In Vitro Degradationmentioning

confidence: 99%

A new insight into in vitro behaviour of poly(ε-caprolactone)/bioactive glass composites in biologically related fluids

et al. 2017

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“…Degradation data for particulate PG-PCL composite given by Prabhakar et al 10 are more rapid than the results given in Figure 1 and may be attributable to different glass formulations ((Na 2 O) 0.552x (CaO) x (P 2 O 5 ) 0.45 in Prabhakar et al) and to the form of the reinforcements, since both surface area and residual stress levels will influence dissolution rates. Prabhakar et al 10 also point out internal voids and microcracks as a means of accelerating dissolution in the aqueous environment.…”

Section: Degradationmentioning

confidence: 83%

“…Prabhakar et al 10 also point out internal voids and microcracks as a means of accelerating dissolution in the aqueous environment. Note also that sizing with 3-aminopropyl triethoxy silane coating the fiber surface may also protect the fibers from rapid hydrolysis, in addition to its main duty as an adhesion promoter.…”

Section: Degradationmentioning

confidence: 96%

Water absorption properties of phosphate glass fiber‐reinforced poly‐ϵ‐caprolactone composites for craniofacial bone repair

Önal

Cozien-Cazuc

Jones

et al. 2007

J of Applied Polymer Sci

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The moisture uptake of polymers and composites has increasing significance where these materials are specified for invasive, long-term medical applications. Here we analyze mass gain and the ensuing degradation mechanisms in phosphate glass fiber reinforced poly-e-caprolactone laminates. Specimens were manufactured using in situ polymerization of e-caprolactone around a bed of phosphate glass fibers. The latter were sized with 3-aminopropyltriethoxysilane to control the rate of modulus degradation. Fiber content was the main variable in the study, and it was found that the moisture diffusion coefficient increased significantly with increasing fiber volume fraction. Diffusion, plasticization, and leaching of constituents appear to be the dominant aspects of the process over these short-term tests.

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“…Unlike bioglass, CRG dissolves completely in fluids at a predetermined rate, leaving no solid residues because phosphorous pentoxide is a main component within its formulation. The metal ions in CRG are found naturally occurring within the body (Probhakar, Brocchini et al 2005) and upon glass degradation (dissolution) the released ions become removed by the bodies own metabolic system without causing a toxic response, avoiding the need for surgical removal if implanted into the body. Because CRG has a controllable solubility in body fluids and do not need surgical removal, this makes them an ideal scaffold material for promoting neotissue formation in vivo (Ahmed, Lewis et al 2003).…”

Section: Tissue Engineering For Tissue and Organ Regeneration 144mentioning

confidence: 99%

Tissue Engineering of Ligaments

Rathbone¹,

Cartmell²

2011

Tissue Engineering for Tissue and Organ Regeneration

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Effect of glass composition on the degradation properties and ion release characteristics of phosphate glass—polycaprolactone composites

Cited by 59 publications

References 25 publications

A new insight into in vitro behaviour of poly(ε-caprolactone)/bioactive glass composites in biologically related fluids

A new insight into in vitro behaviour of poly(ε-caprolactone)/bioactive glass composites in biologically related fluids

Water absorption properties of phosphate glass fiber‐reinforced poly‐ϵ‐caprolactone composites for craniofacial bone repair

Tissue Engineering of Ligaments

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