Effect of ginsenoside Rg<sub>1</sub> on insulin binding in mice liver and brain membranes

Tchilian, Elma; Zhelezarov, I.E.; Hadjiivanova, Ch.

doi:10.1002/ptr.2650050114

Cited by 30 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 Insulin binding in rat liver, brain, and bone marrow was also increased by ginsenoside Rg1 or Asian ginseng extract. [18][19] The third possible mechanism, modulation of glucose transport, suggests that ginseng extracts and compounds may increase glucose transport in various cell lines. In the livers of mice, glucose transporter (GLUT)-2 protein expression was increased by Asian ginseng extract.…”

Section: Discussionmentioning

confidence: 99%

Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Bang

Kwak

Ahn

et al. 2014

Journal of Medicinal Food

View full text Add to dashboard Cite

This study was designed to evaluate the effect of Korean red ginseng (KRG) supplementation on glucose control in subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or newly diagnosed type 2 diabetes mellitus (T2DM). The study was a 12-week randomized, double-blinded, placebo-controlled (5 g of KRG [n = 21] or placebo [n = 20] in tablet form) trial. Glucose-related biomarkers, including serum and whole blood levels of glucose, insulin, and Cpeptide, were measured by 2-h oral glucose tolerance tests (OGTTs) at baseline and after the 12-week intervention. After the intervention, the test group showed a significant decrease in serum levels of glucose at 30 min ( -22.24 -10.77 mg/dL) and whole blood levels of glucose at 30 min ( -17.52 -5.22 mg/dL). In addition, the test group tended to have lower whole blood levels of glucose at 0 min and glucose area under curve (AUC). However, the placebo group did not show any changes in blood glucose-related indices. The changes (difference from baseline) in serum glucose levels at 30 min, whole blood glucose levels at 60 min, and glucose AUC during OGTTs in the test group exhibited a tendency toward a decrease from those in the placebo group. There were significant decreases or trends toward a decrease in both serum insulin and C-peptide concentrations at most time intervals in the test group. In conclusion, KRG supplementation (5 g/day) may be beneficial for controlling serum and whole blood glucose levels compared with placebo among patients with IFG, IGT, or T2DM.

show abstract

Section: Discussionmentioning

confidence: 99%

Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Bang

Kwak

Ahn

et al. 2014

Journal of Medicinal Food

View full text Add to dashboard Cite

show abstract

“…Another important biological effect reported for Panax ginseng or its saponins is hypoglycemic and antihyperglycemic activity (133,134). It has been shown that ginsenoside Rg1 increased the number of insulin receptors (135) and panaxan B, the main constituent of Panax ginseng for hypoglycemic activity, increased the plasma insulin level and enhanced insulin sensitivity (133). Ginseng also shows anti-stress activities against physical (i), chemical (ii), and biological (iii) stressful circumstances.…”

Section: Other Pharmacological Effects Of Ginsengmentioning

confidence: 99%

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Gille²,

et al. 2006

View full text Add to dashboard Cite

Abstract. Ginseng, the root of Panax species, is a well-known herbal medicine. It has been used as a traditional medicine in China, Korea, and Japan for thousands of years and is now a popular and worldwide used natural medicine. The active ingredients of ginseng are ginsenosides which are also called ginseng saponins. Recently, there is increasing evidence in the literature on the pharmacological and physiological actions of ginseng. However, ginseng has been used primarily as a tonic to invigorate week bodies and help the restoration of homeostasis. Current in vivo and in vitro studies have shown its beneficial effects in a wide range of pathological conditions such as cardiovascular diseases, cancer, immune deficiency, and hepatotoxicity. Moreover, recent research has suggested that some of ginseng's active ingredients also exert beneficial effects on aging, central nervous system (CNS) disorders, and neurodegenerative diseases. In general, antioxidant, anti-inflammatory, anti-apoptotic, and immune-stimulatory activities are mostly underlying the possible ginseng-mediated protective mechanisms. Next to animal studies, data from neural cell cultures contribute to the understanding of these mechanisms that involve decreasing nitric oxide (NO), scavenging of free radicals, and counteracting excitotoxicity. In this review, we focus on recently reported medicinal effects of ginseng and summarize the current knowledge of its effects on CNS disorders and neurodegenerative diseases.

show abstract

“…Ginsenoside Rg 1 was reported to increase the number of insulin receptors rather than to change the receptor affinity. 247 Panaxan A was also reported as a main component for hypoglycemic activity of P. ginseng. 248 Research on the mechanisms of hypoglycemic activity suggested that panaxan B increased the plasma insulin level and enhancement of insulin sensitivity, while panaxan A worked by other mechanisms.…”

Section: Antihyperglycemic Effectmentioning

confidence: 99%

Panax ginseng: A Role in Cancer Therapy?

Seo²,

et al. 2003

View full text Add to dashboard Cite

Panax ginseng is a plant that has been used in traditional medicine in China for thousands of years. It is used as a general tonic or adaptogen with chronically ill patients and is frequently featured in traditional medicine prescriptions from China, Japan, and Korea used by cancer patients. The putative active compounds are the ginsenosides, of which there are more than two dozen. These compounds are found in both Panax ginseng and in other Panax species that are used in herbal medicine. Analysis of ginsenosides is being used in developing quality control assessments for ginseng, which has frequently been adulterated due to its high cost; many currently available standardized extracts do appear to contain the amounts of ginsenosides listed on package labeling. The toxicity of ginseng appears to be low: some of the reports of toxic episodes of ginseng may actually pertain to other components of multicomponent preparations. Very low incidence of toxicity has been observed in ginseng clinical trials using well-characterized preparations. Numerous pharmacological activities of ginseng and the ginsenosides have been explored: the authors review here the activities relating to cancer. Immune system modulation, antistress activities, and antihyperglycemic activities are among the most notable features of ginseng noted in laboratory and clinical analyses. Much testing has been done in humans to explore ginseng's purported antifatigue properties, but this area remains controversial. A number of investigations point to antitumor properties and other pharmacological activities related to cancer, but no trials have yet confirmed a clinically significant anticancer activity. Cancer patients may empirically find ginseng to be useful when they are fatigued, although clinical trials should be conducted to confirm its benefits.

show abstract

Effect of ginsenoside Rg₁ on insulin binding in mice liver and brain membranes

Cited by 30 publications

References 18 publications

Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Panax ginseng: A Role in Cancer Therapy?

Contact Info

Product

Resources

About

Effect of ginsenoside Rg1 on insulin binding in mice liver and brain membranes

Cited by 30 publications

References 18 publications

Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Korean Red Ginseng Improves Glucose Control in Subjects with Impaired Fasting Glucose, Impaired Glucose Tolerance, or Newly Diagnosed Type 2 Diabetes Mellitus

Use of Ginseng in Medicine With Emphasis on Neurodegenerative Disorders

Panax ginseng: A Role in Cancer Therapy?

Contact Info

Product

Resources

About

Effect of ginsenoside Rg₁ on insulin binding in mice liver and brain membranes