Effect of Ginsenoside Re on Depression- and Anxiety-Like Behaviors and Cognition Memory Deficit Induced by Repeated Immobilization in Rats

Lee, Bom Bi; Shim, In Sop; Lee, Hye Jung; Hahm, Dae Hyun

doi:10.4014/jmb.1112.12046

Cited by 53 publications

(52 citation statements)

References 51 publications

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“…Previous studies have demonstrated the antidepressant-like effect of an intestinal metabolite of ginseng, 20 (S)-protopanaxadiol in bulbectomized animals (Xu et al, 2010). Lee et al (2012) also showed that treatment with ginsenoside Re decreased immobility time in the forced swimming test.…”

Section: Discussionmentioning

confidence: 94%

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

Holzmann

Silva

et al. 2015

Pharmacology Biochemistry and Behavior

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Section: Discussionmentioning

confidence: 94%

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

Holzmann

Silva

et al. 2015

Pharmacology Biochemistry and Behavior

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“…In particular, G-Re, a compound derived from Panax ginseng, improved anti-diabetic effects by suppression of phospho-JNK and NF-κB in diabetic animals [19]. In addition, G-Re treatment improved cognitive impairment and helpless behaviors by regulation of the noradrenergic system in animal models [20]. However, the molecular mechanisms of G-Re remain unknown.…”

Section: Discussionmentioning

confidence: 99%

Effects of ginsenoside Re on LPS-induced inflammatory mediators in BV2 microglial cells

Lee

Jung

Choi

et al. 2012

BMC Complement Altern Med

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BackgroundMicroglial activation plays an important role in neurodegenerative diseases by producing several pro-inflammatory enzymes and pro-inflammatory cytokines. Lipopolysaccharide (LPS)-induced inflammation leads to the activation of microglial cells in the central nervous system (CNS) and is associated with the pathological mechanisms of neurodegenerative diseases, including PD, AD, and ALS. Ginseng is a natural antioxidant used in herbal medicine and contains ginsenosides (Rb1, Rg1, Rg3, Re, and Rd), which have anti-neoplastic and anti-stress properties.This study demonstrates the involvement of the anti-inflammatory signaling pathway, ginsenoside-Re (G-Re), which is one of the ginsenosides mediated by LPS-induced neuroinflammation in BV2 microglial cells.MethodsBV2 microglial cells were pretreated with 2 μg/ml G-Re and stimulated with 1 μg/ml LPS to induce neuroinflammation. To investigate the effect of G-Re on LPS-induced cell signaling, we performed western blotting and immunofluorescence using specific antibodies, such as phospho-p38, COX2, and iNOS.ResultsPretreatment with 2 μg/ml G-Re was neuroprotective against 1 μg/ml LPS-treated microglial cells. The neuroprotective events induced by G-Re treatment in neuroinflammation occurred via the phospho-p38, iNOS, and COX2 signaling pathways in BV2 cells.ConclusionTaken together, we suggest that G-Re exerts a beneficial effect on neuroinflammatory events in neurodegenerative diseases.

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“…For example, the 5th, 6th, and 7th prescriptions contained several important polyphenols and ginsenoside, including ferulic acid, naringenin, nobiletin, hesperidin, chlorogenic acid, and apigenin (Supplementary Figure S11). Studies have shown that these polyphenols and ginsenoside possessed antidepressant-like activity in animal model of depression57585960. We will further screen the active components of each TCM prescription using the larval locomotor activity assay, thereby isolate them from the mixtures of prescriptions.…”

Section: Discussionmentioning

confidence: 99%

Behavioural screening of zebrafish using neuroactive traditional Chinese medicine prescriptions and biological targets

Wang

Hou

Sun

et al. 2014

Sci Rep

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The mechanism of the therapeutic action of antidepressants remains uncertain in traditional Chinese medicine (TCM). In this study, we selected 7 classical TCM prescriptions and utilised an automatic video-tracking system to monitor the rest/wake behaviour of larval zebrafish at 4 days post-fertilisation (dpf) for 48 hours. We found that the curative effects of the prescriptions were dose-dependent. K-means clustering was performed according to the shared behavioural phenotypes of the zebrafish. The results revealed that the rest/wake behavioural profiles induced by the same class of prescriptions were similar. A correlation analysis was conducted between the TCM prescriptions and the known compounds. The results showed that the TCM prescriptions correlated well with some well-known compounds. Therefore, we predicted that they may share a similar mechanism of action. This paper describes the first study to combine TCM research with zebrafish rest/wake behaviour in vivo and presents a powerful approach for the discovery of the mechanism of action of TCM prescriptions.

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Effect of Ginsenoside Re on Depression- and Anxiety-Like Behaviors and Cognition Memory Deficit Induced by Repeated Immobilization in Rats

Cited by 53 publications

References 51 publications

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

Antidepressant-like effect of quercetin in bulbectomized mice and involvement of the antioxidant defenses, and the glutamatergic and oxidonitrergic pathways

Effects of ginsenoside Re on LPS-induced inflammatory mediators in BV2 microglial cells

Behavioural screening of zebrafish using neuroactive traditional Chinese medicine prescriptions and biological targets

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