Effect of ginseng saponins on cholesterol metabolism. III. Effect of ginsenoside-Rb1 on cholesterol synthesis in rats fed on high-fat diet.

Ikehara, M; Shibata, Yasuo; Higashi, Tokuhiko; Sanada, Shuichi; Shoji, Jun

doi:10.1248/cpb.26.2844

Cited by 11 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase of TC and LDL levels in plasma is the main factor leading to cardiovascular disease. Ginsenoside Rb1 can decrease the cholesterol content in the liver of HFD‐fed mice by suppressing HMGCR (Ikehara, Shibata, Higashi, Sanada, & Shoji, 1978). Rb1 significantly ameliorated hepatic fat accumulation in HFD‐induced obese rats, as demonstrated by reduced liver weight and hepatic triglyceride content (Shen et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

Biotransformation of ginsenoside Rb1 with wild Cordyceps sinensis and Ascomycota sp. and its antihyperlipidemic effects on the diet‐induced cholesterol of zebrafish

Sui

2020

J Food Biochem

View full text Add to dashboard Cite

Biotransformation major ginsenoside into minor ginsenoside via microbial fermentation has been proposed as a viable option to produce minor ginsenoside, because of its biological activity superior to major ginsenoside. Cordyceps sinensis contains a complex enzymatic system and many ingredients with medicinal value that could be useful tools for biotransformation applications in the ginseng industry. Wild C. sinensis and Ascomycota sp. were collected from Changbai Mountain and identified. Analysis by UPLC‐MS and HPLC indicates that the underlying pathway of major ginsenoside Rb1 during fermentation with strains was Rb1→Rd→F2→CK and Rb1→Rd→Rg3. C. sinensis and Ascomycota sp. can be applied to minor ginsenoside preparation in the food and medical industries. The antihyperlipidemic effects of Rb1 were further screened from fermentation in larvae zebrafish based on the fluorescence intensity. In the adult zebrafish model, treatment with high‐dose ginsenoside Rb1 group exhibited a significant decrease in the plasma total cholesterol (TC) and triglyceride (TG) levels by 36.49% (p < .05) and 29.97% (p < .05), respectively, compared with high cholesterol group (HC). Furthermore, ginsenoside Rb1 treatment decreased the mRNA levels of LDLR and SREBP2 in the adult zebrafish liver. Ginsenoside Rb1 diet supplement significantly increased the mRNA expression of HMGCR and CYP7A1. These results suggest that ginsenoside Rb1 attenuates hypercholesterolemia via the downregulation of cholesterol synthesis and assembly or secretion of lipoproteins as well as the upregulation of cholesterol transport and efflux, providing a novel idea of ginsenoside keeping cholesterol levels down for the clinical application. Practical applications Wild Cordyceps sinensis has the potential to be applied to the preparation for minor ginsenoside. Furthermore, the final fermentation product has more functional characteristics, including cordyceps acid, cordycepin, and adenosine. Wild Cordyceps sinensis and Ascomycota sp. could potentially be employed in the food and medical industries.

show abstract

Section: Resultsmentioning

confidence: 99%

Biotransformation of ginsenoside Rb1 with wild Cordyceps sinensis and Ascomycota sp. and its antihyperlipidemic effects on the diet‐induced cholesterol of zebrafish

Sui

2020

J Food Biochem

View full text Add to dashboard Cite

show abstract

“…It has been shown that red ginseng extract and ginsenosides can increase the expression of CYP7A1, CYP8B1, and MRP2 in vitro and in vivo [81] , [82] . Ginsenoside Rb1 can decrease the cholesterol content in the liver of HFD-fed mice by suppressing HMGCR [83] , and ginsenoside Rb2 can upregulate the expression of the low density lipoprotein receptor (LDL-R), which mediates the clearance of cholesterol from plasma to hepatocytes [55] , [84] . Qureshi et al [68] and Muwalla and Abuirmeileh [85] showed that dietary supplementation of ginseng can suppress avian hepatic cholesterogenesis and decrease plasma LDL cholesterol.…”

Section: Effect On Livermentioning

confidence: 99%

Ginseng and obesity

2018

Journal of Ginseng Research

View full text Add to dashboard Cite

Although ginseng has been shown to have an antiobesity effect, antiobesity-related mechanisms are complex and have not been completely elucidated. In the present study, we evaluated ginseng’s effects on food intake, the digestion, and absorption systems, as well as liver, adipose tissue, and skeletal muscle in order to identify the mechanisms involved. A review of previous in vitro and in vivo studies revealed that ginseng and ginsenosides can increase energy expenditure by stimulating the adenosine monophosphate-activated kinase pathway and can reduce energy intake. Moreover, in high fat diet-induced obese and diabetic individuals, ginseng has shown a two-way adjustment effect on adipogenesis. Nevertheless, most of the previous studies into antiobesity effects of ginseng have been animal based, and there is a paucity of evidence supporting the suggestion that ginseng can exert an antiobesity effect in humans.

show abstract

“…Further, Rb 2 enhanced the fibrinolytic activity of bovine aortic endothelial cells [14]. In contrast, the hypolipidemic effects of ginseng saponins were examined in rats fed a high-fat diet and in cyclophosphamideinduced hyperlipidemic rabbits [15,16]. Yokozawa et al [17] demonstrated the hyperlipidemia-improving and hypoglycemic effects of Rb 2 on streptozotocin-induced diabetic rats.…”

Section: Identification Of Anticoagulant Components In Korean Red Ginmentioning

confidence: 99%

Identification of Anticoagulant Components in Korean Red Ginseng

Wee¹,

Kim²,

Kyung³

et al. 2010

Journal of Ginseng Research

View full text Add to dashboard Cite

In this study, the anticoagulant compounds in Korean red ginseng (KRG) were investigated. KRG powder was extracted using hot methanol, and the methanol extract was fractionated into n-hexane, ethylacetate, n-butanol, and aqueous fractions by solvent partitioning. The remains from the methanol extraction were further extracted with water and then dialyzed to obtain low and high molecular weight fractions. The anticoagulant activities of the seven fractions were evaluated in terms of thrombin time, prothrombin time, and activated partial thromboplastin time. Among these fractions, the ethylacetate fraction showed the most potent anticoagulant activity. The active components in the ethylacetate fraction were identified as the phenolic compounds vanillic, caffeic, ferulic, and p-coumaric acid via TLC and HPLC. These findings suggest that the anticoagulant activities of phenolic compounds contribute to the cardiovascular effects of KRG.

show abstract

Effect of ginseng saponins on cholesterol metabolism. III. Effect of ginsenoside-Rb1 on cholesterol synthesis in rats fed on high-fat diet.

Cited by 11 publications

References 0 publications

Biotransformation of ginsenoside Rb1 with wild Cordyceps sinensis and Ascomycota sp. and its antihyperlipidemic effects on the diet‐induced cholesterol of zebrafish

Biotransformation of ginsenoside Rb1 with wild Cordyceps sinensis and Ascomycota sp. and its antihyperlipidemic effects on the diet‐induced cholesterol of zebrafish

Ginseng and obesity

Identification of Anticoagulant Components in Korean Red Ginseng

Contact Info

Product

Resources

About