Effect of ginger (Zingiber officinale) on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials

Morvaridzadeh, Mojgan; Fazelian, Siavash; Agah, Shahram; Khazdouz, Maryam; Rahimlou, Mehran; Agh, Fahimeh; Potter, Eric; Heshmati, Shilan; Heshmati, Javad

doi:10.1016/j.cyto.2020.155224

Cited by 70 publications

(66 citation statements)

References 50 publications

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“…If neuroinflammation is involved in the pathogenesis of hydrocephalus, inflammatory markers may serve as novel disease biomarkers. Modulation of inflammatory pathways affects a range of systemic illnesses [59,60] and may well serve as potential targets for pharmacological management of hydrocephalus. We reviewed the results presented in 22 studies, which investigated the presence of 58 inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review

et al. 2021

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Objective. The aim of this systematic review was to evaluate existing literature on inflammatory markers in CSF from patients with hydrocephalus and identify potential markers capable of promoting hydrocephalus development and progression. Methods. Relevant studies published before December 3rd 2020 were identified from PubMed, Embase, and reference lists. Studies were screened for eligibility using the predefined inclusion and exclusion criteria. Data from eligible studies were extracted, and sources of bias were evaluated. We included articles written in English investigating inflammatory markers in CSF from patients with hydrocephalus and control subjects. The review was conducted according to the PRISMA guidelines by three independent reviewers. Results. Twenty-two studies analyzed CSF from 311 patients with idiopathic normal pressure hydrocephalus (iNPH), 178 with posthemorrhagic hydrocephalus (PHH), 151 with other hydrocephalus diagnoses, and 394 control subjects. Fifty-eight inflammatory markers were investigated. The CSF of iNPH patients had increased CSF levels of IL-6, IL-1β, and LRG compared with control subjects, whereas the CSF of PHH patients had increased levels of IL-6, IL-18, and VEGF. CSF from patients with “other hydrocephalus diagnoses” had elevated IFN-γ compared to control subjects, and VEGF was increased in congenital hydrocephalus, spina bifida, and hydrocephalus associated with tuberculous meningitis compared with controls. Conclusion. IL-6, IL-1β, LRG, IL-18, VEGF, and IFN-γ are elevated in CSF from patients with hydrocephalus and may be involved in promotion of hydrocephalus development and progression. They may serve as novel disease biomarkers, and their signaling pathways may represent targets for pharmacological management of hydrocephalus.

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Section: Discussionmentioning

confidence: 99%

Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review

et al. 2021

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“…The first, based on 20 clinical trials showed that ginger had a statistically significant effect on serum C‐reactive protein, TNF‐α, IL‐6, total antioxidant capacity, and malondialdehyde levels (Jalali et al, 2020). The second, which included 16 RCTs ( n = 1,010 participants), demonstrated a significant impact of ginger in lowering circulating C‐reactive protein and TNF‐α levels (Morvaridzadeh et al, 2020).…”

Section: Antiinflammatory and Analgesic Effectsmentioning

confidence: 99%

Ginger (Zingiber officinale Roscoe) as a nutraceutical: Focus on the metabolic, analgesic, and antiinflammatory effects

Pagano

Souto

Durazzo

et al. 2020

Phytotherapy Research

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Ginger (from the rizhome of Zingiber officinale Roscoe) has been widely used in ethnomedicine for the cure of several ailments. Main active ingredients include phenolic compounds named gingerols. In modern phytotherapy, ginger preparations are predominantly used to counteract nausea and vomiting in pregnant women. However, a number of other pharmacological actions of potential therapeutic interest, which might broaden the spectrum of its clinical use, have been reported. This focused review aims at giving a shot on the antinflammatory, analgesic, and metabolic actions of Zingiber officinale preparations, with a discussion on the clinical applications in knee osteoarthritis, dysmenorrhea, type-2 diabetes, hyperlipidemia, overweight, and obesity.

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“…Traditional Chinese medicine (TCM) is beneficial for chronic diseases [ 19 ]. For example, ginger has a significant effect on reducing circulating C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF- α ) levels, which are systemic inflammatory markers associated with an increased risk of cardiovascular disease [ 20 ]. Curcumin may ameliorate hyperandrogenemia and hyperglycemia associated with polycystic ovary syndrome [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Antiaging Effects of 23 Traditional Chinese Medicines

Wang

Zuo

Ouyang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Aging is an inevitable stage of body development. At the same time, aging is a major cause of cancer, cardiovascular disease, and neurodegenerative diseases. Chinese herbal medicine is a natural substance that can effectively delay aging and is expected to be developed as antiaging drugs in the future. Aim of the review. This paper reviews the antiaging effects of 23 traditional Chinese herbal medicines or their active components. Materials and methods. We reviewed the literature published in the last five years on Chinese herbal medicines or their active ingredients and their antiaging role obtained through the following databases: PubMed, EMBASE, Scopus, and Web of Science. Results. A total of 2485 papers were found, and 212 papers were screened after removing the duplicates and reading the titles. Twenty-three studies met the requirements of this review and were included. Among these studies, 13 articles used Caenorhabditis elegans as the animal model, and 10 articles used other animal models or cell lines. Conclusion. Chinese herbal medicines or their active components play an antiaging role by regulating genes related to aging through a variety of signaling pathways. Chinese herbal medicines are expected to be developed as antiaging drugs or used in the medical cosmetology industry.

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Effect of ginger (Zingiber officinale) on inflammatory markers: A systematic review and meta-analysis of randomized controlled trials

Cited by 70 publications

References 50 publications

Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review

Inflammatory Markers in Cerebrospinal Fluid from Patients with Hydrocephalus: A Systematic Literature Review

Ginger (Zingiber officinale Roscoe) as a nutraceutical: Focus on the metabolic, analgesic, and antiinflammatory effects

A Systematic Review of Antiaging Effects of 23 Traditional Chinese Medicines

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