Effect of geometric modification of fumed nanoscale silica for medical applications on adsorption of human serum albumin: Physicochemical and surface properties

Nanostructure and thermal characteristics of silica/human serum albumin systems based on a modified nanosilica entero-vulnerosorbent

“…The details of the geometric modification are described in our previous paper. 39 The textural parameters of the obtained nanosilica materials after geometric modification were evaluated based on nitrogen adsorption/desorption isotherms, i.e., the specific surface area 296 m 2 g À1 , 286 m 2 g À1 , 283 m 2 g À1 , the average pore diameter 16.6 nm, 15.1 nm, 10.3 nm, and the total pore volume 1.15 cm 3 g À1 , 1.0 cm 3 g À1 , 0.71 cm 3 g À1 for GM-1 h, GM-4 h, and GM-7 h, respectively. 39 The maximal bulk density, d b = 275 g cm À3 (V em = 3.2 cm 3 g À1 ) was reached for the GMtreated sample in 7 h (GM-7 h).…”

“…39 The textural parameters of the obtained nanosilica materials after geometric modification were evaluated based on nitrogen adsorption/desorption isotherms, i.e., the specific surface area 296 m 2 g À1 , 286 m 2 g À1 , 283 m 2 g À1 , the average pore diameter 16.6 nm, 15.1 nm, 10.3 nm, and the total pore volume 1.15 cm 3 g À1 , 1.0 cm 3 g À1 , 0.71 cm 3 g À1 for GM-1 h, GM-4 h, and GM-7 h, respectively. 39 The maximal bulk density, d b = 275 g cm À3 (V em = 3.2 cm 3 g À1 ) was reached for the GMtreated sample in 7 h (GM-7 h). Mechanical treatments of nanosilica samples give a higher bulk density of the powder (i.e., d b = 191 g cm À3 , V em = 4.8 cm 3 g À1 for GM-1 h, d b = 234 g cm À3 , V em = 3.8 cm 3 g À1 for GM-4 h).…”

“…Mechanical treatments of nanosilica samples give a higher bulk density of the powder (i.e., d b = 191 g cm À3 , V em = 4.8 cm 3 g À1 for GM-1 h, d b = 234 g cm À3 , V em = 3.8 cm 3 g À1 for GM-4 h). 39…”

“…In our previous work, the geometric (GM) modification of fumed nanosilica was carried out by mechanical treatment (MT) under different time conditions (t MT = 1, 4, 7 h) in order to increase its bulk density to obtain an optimal enterosorbent with an approvable level of HSA adsorption capacity. 39 The surface and structure (specific surface area, particle shape, pore size, and pore volume) characteristics upon geometrical modification determine the application efficiency of the unmodified and modified materials. [39][40][41][42][43] In particular, the surface properties (chemistry, micronanostructure, morphology, and topography) determine the amount, density, and structure of the biofilms, as well as the distribution of the immobilized HSA molecules on the surfaces.…”

“…39 The surface and structure (specific surface area, particle shape, pore size, and pore volume) characteristics upon geometrical modification determine the application efficiency of the unmodified and modified materials. [39][40][41][42][43] In particular, the surface properties (chemistry, micronanostructure, morphology, and topography) determine the amount, density, and structure of the biofilms, as well as the distribution of the immobilized HSA molecules on the surfaces. 44,45 Therefore, this paper aims to study the influence of the particle morphology, micro-nanostructure, and roughness of the surface of modified silica on the degree of surface coverage with human albumin.…”