Effect of genistein, daidzein and coumestrol on sex-related genes expression in Russian sturgeon (Acipenser gueldenstaedtii)

Fajkowska, Magdalena; Adamek‐Urbańska, Dobrochna; Ostaszewska, Teresa; Szczepkowski, M.; Rzepkowska, Małgorzata

doi:10.1016/j.aquaculture.2020.735872

Cited by 5 publications

(3 citation statements)

References 71 publications

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“…Wang et al (2020) demonstrated that the agonistic activity of equol to erα in wild mullet Mugil soiuy was 3.5 times higher than that of medaka, correlating to a stronger potential to induce intersex. In sturgeon fed the phytoestrogen daidzein, erα and erβ were significantly upregulated in both normal and intersex males when compared to controls, while females, normal, and intersex males all had upregulated vtg (Fajkowska et al, 2021). It has been suggested that knowledge of transcriptional changes at the organismal level can be used by scientists and management agencies as early warning signals of potential population-level effects (Connon et al, 2012), which could be used to support managerial action.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Reproductive health and endocrine disruption in smallmouth bass (Micropterus dolomieu) from the Lake Erie drainage, Pennsylvania, USA

Walsh

Rafferty

Gordon

et al. 2021

Environ Monit Assess

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Smallmouth bass Micropterus dolomieu were sampled from three sites within the Lake Erie drainage (Elk Creek, Twentymile Creek, and Misery Bay, an embayment in Presque Isle Bay). Plasma, tissues for histopathological analyses, and liver and testes preserved in RNALater® were sampled from 30 smallmouth bass (of both sexes) at each site. Liver and testes samples were analyzed for transcript abundance with Nanostring nCounter® technology. Evidence of estrogenic endocrine disruption was assessed by the presence and severity of intersex (testicular oocytes; TO) and concentrations of plasma vitellogenin in male fish. Abundance of 17 liver transcripts associated with reproductive function, endocrine activity, and contaminant detoxification pathways and 40 testes transcripts associated with male and female reproductive function, germ cell development, and steroid biosynthesis were also measured. Males with a high rate of TO (87–100%) and plasma vitellogenin were noted at all sites; however, TO severity was greatest at the site with the highest agricultural land cover. Numerous transcripts were differentially regulated among the sites and patterns of transcript abundance were used to better understand potential risk factors for estrogenic endocrine disruption. The results of this study suggest endocrine disruption is prevalent in this region and further research would benefit to identify the types of contaminants that may be associated with the observed biological effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Reproductive health and endocrine disruption in smallmouth bass (Micropterus dolomieu) from the Lake Erie drainage, Pennsylvania, USA

Walsh

Rafferty

Gordon

et al. 2021

Environ Monit Assess

View full text Add to dashboard Cite

show abstract

“…In Japanese medaka (Oryzias latipes), genistein exposure induced feminization of genetic males [25], whereas, in channel catfish (Ictalurus punctatus), genistein treatment during the period of sex differentiation led to a higher proportion of male and intersex fish [24]. In Russian sturgeon (Acipenser gueldenstaedtii), the dietary phytoestrogens genistein, daidzein, and coumestrol were shown to modulate sex-related genes, leading to endocrine effects [26]. In European eels (Anguilla anguilla) fed 2 mg/kg genistein for 100 days, the proportion of females was 55%, but at 20 mg/kg, the proportion of females was only 15% [27].…”

Section: Introductionmentioning

confidence: 99%

Soy Isoflavones Induce Feminization of Japanese Eel (Anguilla japonica)

Inaba

Iwata

Suzuki³

et al. 2022

IJMS

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Under aquaculture conditions, Japanese eels (Anguilla japonica) produce a high percentage of males. However, females gain higher body weight and have better commercial value than males, and, therefore, a high female ratio is required in eel aquaculture. In this study, we examined the effects of isoflavones, genistein, and daidzein on sex differentiation and sex-specific genes of eels. To investigate the effects of these phytoestrogens on the gonadal sex, we explored the feminizing effects of soy isoflavones, genistein, and daidzein in a dose-dependent manner. The results showed that genistein induced feminization more efficiently than daidzein. To identify the molecular mechanisms of sex-specific genes, we performed a comprehensive expression analysis by quantitative real-time PCR and RNA sequencing. Phenotypic males and females were produced by feeding elvers a normal diet or an estradiol-17β- or genistein-treated diet for 45 days. The results showed that female-specific genes were up-regulated and male-specific genes were down-regulated in the gonads, suggesting that genistein induces feminization by altering the molecular pathways responsible for eel sex differentiation.

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Direct and Indirect Photodegradation of Daidzein in Different Dissociated Forms in Water: Theoretical Analysis Based on DFT/TDDFT

Lu,

Shen,

Wang

2024

Water Air Soil Pollut

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Effect of genistein, daidzein and coumestrol on sex-related genes expression in Russian sturgeon (Acipenser gueldenstaedtii)

Cited by 5 publications

References 71 publications

Reproductive health and endocrine disruption in smallmouth bass (Micropterus dolomieu) from the Lake Erie drainage, Pennsylvania, USA

Reproductive health and endocrine disruption in smallmouth bass (Micropterus dolomieu) from the Lake Erie drainage, Pennsylvania, USA

Soy Isoflavones Induce Feminization of Japanese Eel (Anguilla japonica)

Direct and Indirect Photodegradation of Daidzein in Different Dissociated Forms in Water: Theoretical Analysis Based on DFT/TDDFT

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