Effect of genetically modified corn on the jejunal mucosa of adult male albino rat

Ibrahim, Marwa A.; Okasha, Ebtsam F.

doi:10.1016/j.etp.2016.10.001

Cited by 9 publications

(11 citation statements)

References 29 publications

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“…Different plant varieties with improved characteristics such as resistance to insect, herbicides tolerance, and enhanced nutritional quality have been developed successfully. Recently there are more than 200 different transgenic crops having different characters approved for consumption in various countries ( 3 ). Genetically modified (GM) plants with a “ Bt ” gene expressing an insecticidal protein provide an improved technology for sustainable crop production.…”

Section: Introductionmentioning

confidence: 99%

Nutritional Assessment of Dietary Bt and Cp4EPSPS Proteins on the Serum Biochemical Changes of Rabbits at Different Developmental Stages

et al. 2018

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In recent years, the influence of genetically modified (GM) cotton expressing different types of Bt and EPSPS genes has been attested in term of reduced application of pesticides and insecticides coupled with improved cotton production. Although the cultivation of GM cotton has been authorized by the regulatory authorities of various countries in the world, based on the biosafety studies reported by most of the GM cotton producers, yet the information on its safe use are inadequate. In order to support the issues on food safety, it is therefore mandatory to conduct further safety assessment studies on GM cotton for each independent transgenic event on the basis of case assessment rule. In the present study, the effects of different doses of dietary GM cotton seed expressing Bt and EPSPS genes were studied on the level of serum biochemical in albino rabbits (Oryctolagus cuniculus). The rabbits were fed a diet containing different levels of GM cotton seeds (i.e., 20, 30, and 40% w/w) respectively mixed with standard diet for 180 days. During the course of the study, various serum enzymes, electrolytes, proteins, glucose and serum total cholesterol were examined at specific time intervals (0, 45, 90, 135, and 180) days. The results showed non-significant (P > 0.05) dose dependent effects in most of the evaluated serum biochemical parameters. Although, the results in some of the serum biochemistry were significantly different (P < 0.05) among the groups, however, they were not biologically significant, since all the differences were within the normal physiological range. These results thus, suggested that the GM cotton seed meal could be considered as safe as other conventional feed ingredients. The experimental evidence for the safe usage of GM cotton was highlighted in this study.

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Section: Introductionmentioning

confidence: 99%

Nutritional Assessment of Dietary Bt and Cp4EPSPS Proteins on the Serum Biochemical Changes of Rabbits at Different Developmental Stages

et al. 2018

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“…Ibrahim and Okasha () evaluated the effect of GM maize on the histological structure of jejunal mucosa of adult male albino rats using different histological, immunohistochemical and morphometrical methods. Histopathological changes were claimed in the intestine.…”

Section: Scientific Quality Of the Studiesmentioning

confidence: 99%

“…() observed differences in organ size and other parameters in rats fed a diet with GM maize versus controls. In this case, the same mistakes in Ibrahim and Okasha () committed (discussed above) were made. El‐Shamei et al .…”

Section: Scientific Quality Of the Studiesmentioning

confidence: 99%

Characterization of scientific studies usually cited as evidence of adverse effects of GM food/feed

Sánchez

Parrott

2017

Plant Biotechnology Journal

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SummaryGM crops are the most studied crops in history. Approximately 5% of the safety studies on them show adverse effects that are a cause for concern and tend to be featured in media reports. Although these reports are based on just a handful of GM events, they are used to cast doubt on all GM crops. Furthermore, they tend to come from just a few laboratories and are published in less important journals. Importantly, a close examination of these reports invariably shows methodological flaws that invalidate any conclusions of adverse effects. Twenty years after commercial cultivation of GM crops began, a bona fide report of an adverse health effect due to a commercialized modification in a crop has yet to be reported.

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“…Moreover, misinterpretation of artefactual or anatomical features was noted. Therefore, EFSA concludes that the findings reported by Ibrahim and Okasha () do not add scientific evidence sufficient to change the conclusions on the safety on maize MON 810.…”

mentioning

confidence: 99%

Annual post‐market environmental monitoring report on the cultivation of genetically modified maize MON 810 in 2016

Álvarez¹,

Devos²,

Georgiadis³

et al. 2018

EFS2

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Following a request from the European Commission, EFSA assessed the annual post-market environmental monitoring (PMEM) report for the 2016 growing season of the Cry1Ab-expressing maize event MON 810 provided by Monsanto Europe S.A. Partial compliance with refuge requirements was reported in Spain, as observed in previous years. EFSA reiterates the need to achieve full compliance in areas of high maize MON 810 adoption to delay resistance evolution, and therefore advocates increasing the level of compliance in such areas. Resistance monitoring data do not indicate a decrease in susceptibility to the Cry1Ab protein in the field corn borer populations tested in the 2016 season. However, EFSA identified some methodological and reporting limitations pertaining to resistance monitoring that need improvement in future PMEM reports. No complaints related to corn borer infestation of maize MON 810 were received via the farmer alert system during the 2016 cultivation season. EFSA encourages the consent holder to provide more information on this complementary resistance monitoring tool. The data on general surveillance do not indicate any unanticipated adverse effects on human and animal health or the environment arising from the cultivation of maize MON 810. EFSA reiterates its recommendations on the methodology and analysis of farmer questionnaires, and considers that future literature searches on maize MON 810 performed in the context of annual PMEM reports should follow the guidelines given in the 2017 EFSA explanatory note on literature searching. Moreover, EFSA encourages relevant stakeholders to implement a methodological framework that enables the use of existing networks in the broader context of environmental monitoring. EFSA concludes that no new evidence has been reported in the 2016 PMEM report that would invalidate previous EFSA evaluations on the safety of maize MON 810.

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Effect of genetically modified corn on the jejunal mucosa of adult male albino rat

Cited by 9 publications

References 29 publications

Nutritional Assessment of Dietary Bt and Cp4EPSPS Proteins on the Serum Biochemical Changes of Rabbits at Different Developmental Stages

Nutritional Assessment of Dietary Bt and Cp4EPSPS Proteins on the Serum Biochemical Changes of Rabbits at Different Developmental Stages

Characterization of scientific studies usually cited as evidence of adverse effects of GM food/feed

Annual post‐market environmental monitoring report on the cultivation of genetically modified maize MON 810 in 2016

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