Effect of gastrectomy on biliary dynamics.

Wyatt, A P

doi:10.1136/gut.10.2.91

Cited by 8 publications

(4 citation statements)

References 4 publications

(4 reference statements)

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“…Early work by Wyatt (1967Wyatt ( , 1969 showed that gastric peristaltic contractions decreased the SO perfusion resistance and a Polya type of gastrectomy ceased this coordination but did not cause biliary hypertension reflecting an increase in the SO resistance in the dog. Although the coordination of the gastric contraction and the SO motility was not observed in the present experiment, the perfusion pressure of the SO, an indicator of its resistance, and the frequency of phasic contractions of the SO increased significantly after gastrectomy (from the level at the gastric and gastroepiploic vessel to the uppermost duodenum), but not after sham-gasterctomy or vagosympathectomy.…”

Section: Discussionmentioning

confidence: 99%

Effects of Gastrectomy on Motility, Perfusion Pressure, and Caerulein-Induced Relaxation of Sphincter of Oddi in Dogs.

Kobayashi¹,

Hosoba²,

Mori³

et al. 1994

J. Smooth Muscle Res.

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Section: Discussionmentioning

confidence: 99%

Effects of Gastrectomy on Motility, Perfusion Pressure, and Caerulein-Induced Relaxation of Sphincter of Oddi in Dogs.

Kobayashi¹,

Hosoba²,

Mori³

et al. 1994

J. Smooth Muscle Res.

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“…To further complicate our understanding of SO activity, the SO has distinct regions and intra‐sphincteric reflexes may exist between these regions 11,51,52 . In addition, SO activity is also modulated by neural reflexes that exist between the SO and the stomach, 53,54 the duodenum, 14,37,40,55,56 and the CBD/gallbladder 57–59 . Of these reflexes, the most extensively studied is the duodenal‐SO reflex.…”

Section: Neural Reflexes Between the So And Other Organsmentioning

confidence: 99%

The sphincter of Oddi: understanding its control and function

Woods

Mawe

Toouli

et al. 2005

Neurogastroenterology Motil

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The most common functional disorders of the biliary tract and pancreas are associated with disordered motility of the sphincter of Oddi (SO). The SO is a neuromuscular structure located at the junction of the bile and pancreatic ducts with the duodenum. The primary functions of the SO are to regulate the delivery of bile and pancreatic juice into the duodenum, and to prevent the reflux of duodenal contents into the biliary and pancreatic systems. Disordered motility of the SO leads to the common and painful clinical conditions of SO dysfunction and acute pancreatitis. In order to understand normal SO motility, studies have been performed addressing SO function, control of spontaneous SO activity, responses to bioactive agents, SO innervation, and reflexes with other gastrointestinal organs. These studies have led to the current understanding of how the SO functions and may permit the development of targeted therapy for SO dysfunction and acute pancreatitis. This review summarizes the current knowledge regarding the control and regulation of SO motility, highlighting laboratory based and clinical research performed over the last 5 years.

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“…The object of this review was to see whether, in fact, ulcer surgery might be a significant aetiological factor in cholelithiasis. Johnson andBoyden (1952), Cox et al (1958), and Tinker and Cox (1969) noted alterations of gall-bladder physiology after vagotomy, and Wyatt (1969) noted changes after partial gastrectomy. After vagotomy there is an increased gall-bladder volume with increased emptying rate, the gall bladder becoming supersensitive to cholecystokinin.…”

Section: Commentmentioning

confidence: 99%