Effect of gaseous hydrogen sulphide on growth performance and cecal microbial diversity of weaning pigs

Cui, Jiansheng; Wu, Fengyang; Yang, Xinyu; Liu, Tingting; Xia, Xueru; Chang, Xingfa; Wang, Haonan; Sun, Lei; Wei, Yuchao; Jia, Zenghao; Liu, Shudong; Han, Shuaijuan; Chen, Baojiang

doi:10.1002/vms3.324

Cited by 3 publications

(5 citation statements)

References 43 publications

(49 reference statements)

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“…Several studies have reported a higher faecal level of Escherichia coli and several Klebsiella in patients with IBS compared to non‐IBS controls 40–43 . Our data showed that these putative pathogens may contribute to intestinal production of hydrogen sulphide and served as an important component of intestinal gas leading to bloating 38,44,45 . Besides, hydrogen sulphide is a potential biomarker for small intestinal bacterial overgrowth in diarrhoea‐predominant IBS 37 .…”

Section: Discussionsupporting

confidence: 52%

“…At the microbiome functional level, in the FMT arm, the relative abundance of 22 metabolic pathways was significantly increased, while 34 pathways were significantly decreased at week 12 compared with baseline (FDR <0.05, Figure 4B). Among them, the most significantly decreased metabolic pathway in patients after receiving FMT was Assimilatory sulfate reduction I, which was known to produce hydrogen sulphide and may contribute to bloating 37–39 . The top bacteria species that contributed to the Assimilatory sulfate reduction I pathway were Escherichia coli and several Klebsiella (Figure 4C), and there was a significant decrease in the total relative abundance of these bacteria in FMT arm ( p = 0.02, Figure 4D), while no change was seen in the placebo arm ( p = 0.45).…”

Section: Resultsmentioning

confidence: 99%

“…Among them, the most significantly decreased metabolic pathway in patients after receiving FMT was Assimilatory sulfate reduction I, which was known to produce hydrogen sulphide and may contribute to bloating. [37][38][39] The top bacteria species that contributed to the Assimilatory sulfate reduction I pathway were Escherichia coli and several Klebsiella (Figure 4C), and there was a significant decrease in the total relative abundance of these bacteria in FMT…”

Section: Microbiome Dynamicsmentioning

confidence: 99%

“…[40][41][42][43] Our data showed that these putative pathogens may contribute to intestinal production of hydrogen sulphide and served as an important component of intestinal gas leading to bloating. 38,44,45 Besides, hydrogen sulphide is a potential biomarker for small intestinal bacterial overgrowth in diarrhoea-predominant IBS. 37 Our results showed that FMT can significantly decrease the relative abundance of hydrogen sulphide production pathway by reducing Escherichia coli and several Klebsiella.…”

Section: F I G U R Ementioning

confidence: 99%

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Randomised clinical trial: Faecal microbiota transplantation for irritable bowel syndrome with diarrhoea

Yau,

Su,

et al. 2023

Aliment Pharmacol Ther

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SummaryBackgroundFaecal microbiota transplantation (FMT) has been shown to improve symptoms in a proportion of patients with irritable bowel syndrome (IBS).AimWe performed a randomised trial to assess the efficacy of FMT in patients with IBS.MethodsWe randomised 56 patients with diarrhoea‐predominant IBS 1:1 to FMT or placebo via the duodenal route at baseline and week 4. The primary outcome was > 50 points decrease in IBS severity scoring system (IBS‐SSS) score at week 12. Secondary outcomes were improvement in bloating and change in gut microbiota at week 12. After 12‐week follow‐up, those in the placebo group were assigned to receive open‐label FMT.ResultsAt week 12, 57.1% in the FMT group and 46.4% in the placebo group achieved the primary endpoint (p = 0.42). More patients receiving FMT than placebo had improvement in bloating (72% vs 30%; p = 0.005). In an open‐label extension, 65.2% and 82.4% of patients achieved, respectively, the primary endpoint and improvement in bloating. Faecal microbiome of patients in the FMT group showed a reduction in bacteria like Ruminococcus gnavus and enrichment of bacteria such as Lawsonibacter at week 12, while no change in the placebo group. Functional analyses showed that the hydrogen sulphide‐producing pathway decreased in patients who had FMT (p < 0.05) accompanied by a reduction in contributing bacteria. There were no serious adverse events related to FMT.ConclusionFMT performed twice at an interval of four weeks did not significantly reduce IBS‐SSS score. However, more patients had improvement in abdominal bloating, which was associated with a reduction in hydrogen sulphide‐producing bacteria. (ClinicalTrials.gov NCT03125564).

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Section: Discussionsupporting

confidence: 52%

Section: Resultsmentioning

confidence: 99%

Section: Microbiome Dynamicsmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

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Randomised clinical trial: Faecal microbiota transplantation for irritable bowel syndrome with diarrhoea

Yau,

Su,

et al. 2023

Aliment Pharmacol Ther

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“…Hydrogen sulfide has antioxidant and immune-regulatory properties, and it can also serve as an oral gas biomarker for IBS-D, 18 while our findings explain that the accumulated hydrogen sulfide is from the increased SO4ASSIM pathway. Some studies have directly confirmed that hydrogen sulfide can induce diarrhea, 19 thus it may also be responsible for the altered stool quality in IBS-D patients. In addition, the LACTOSECAT pathway (increased in IBS-C but decreased in IBS-D and IBS-U) is mainly involved in the degradation of lactose and galactose, and a decrease in this function appears to cause lactose-related dyspepsia, which is an important trigger for IBS symptoms.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiome signatures reflect different subtypes of irritable bowel syndrome

Tun

Liu

et al. 2022

Gut Microbes

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Irritable bowel syndrome (IBS) is a heterogeneous condition with multifactorial pathogenesis. We studied deeply phenotyped individuals with microbiota sequencing enrolled in the American Gut Project. The IBS subjects were matched by age, gender, body mass index, geography, and dietary patterns with non-IBS controls. A total of 942 subjects with IBS-Diarrhea (IBS-D), IBS-Constipation (IBS-C), unclassified IBS (IBS-U), and 942 non-IBS controls were included. We compared taxonomic and functional composition of gut microbiota based on 16S sequencing data and linked them with clinical characteristics and dietary factors. Subjects with IBS-D or IBS-U but not IBS-C showed significantly reduced bacterial diversity (Shannon; p < .01). Distinct bacterial signatures were associated with different IBS subtypes, and the related functional changes were related to IBS pathogenesis, such as the increased hydrogen sulfide production pathway in IBS-D and the increased palmitoleate biosynthesis pathway in IBS-C. IBS subjects with depression showed lower abundance of Bifidobacterium, Sutterella, Butyricimonas and higher abundance of Proteus than those without depression. The relative abundance of microbial short-chain fatty acid production pathways was significantly lower in IBS patients with depression than those without depression in all three subtypes. Female, younger age in IBS-D, and older age in IBS-C were associated with more severe microbiota dysbiosis, and distinct dietary factors had significant effects on the gut microbiota in different IBS subtypes. Our analysis identified the compositional uniqueness of gut microbiota in different IBS subtypes. Distinct associations of the gut microbiota with depression in IBS provide insights into shared pathways in disease pathogenesis. These findings highlight the importance of personalized gut microbiome modulation approaches in different subtypes for optimal therapeutic effects.

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Sulfide causes histological damage, oxidative stress, metabolic disorders and gut microbiota dysbiosis in juvenile sea cucumber Apostichopus japonicus Selenka

Zhao

Wang

et al. 2023

Aquatic Toxicology

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Effect of gaseous hydrogen sulphide on growth performance and cecal microbial diversity of weaning pigs

Cited by 3 publications

References 43 publications

Randomised clinical trial: Faecal microbiota transplantation for irritable bowel syndrome with diarrhoea

Randomised clinical trial: Faecal microbiota transplantation for irritable bowel syndrome with diarrhoea

Gut microbiome signatures reflect different subtypes of irritable bowel syndrome

Sulfide causes histological damage, oxidative stress, metabolic disorders and gut microbiota dysbiosis in juvenile sea cucumber Apostichopus japonicus Selenka

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