Effect of garlic (Allium sativum L.) extract on degree of hydration, fructose, sulphur and phosphorus contents of rat eyelens and intestinal absorption of nutrients

Abstract

Influence of aqueous garlic extract on degree of hydration, fructose, sulphur and phosphorus contents of rat eyelens and intestinal absorption of nutrients were assessed. Inclusion of garlic extract in culture medium containing glucose and xylose inhibited the hydration of rat eyelens, whereas galactose evinced the reverse trend. Aqueous garlic extract in general decreased the concentration of fructose and phosphorus, whereas sulphur concentration increased when rat eyelenses, were incubated with galactose and xylose. Garlic extract inhibited intestinal absorption of glutamic acid, sucrose and glucose to different extents. The rate of absorption of glutamic acid was found to be considerably higher than that of glucose and sucrose. KEY WORDSGarlic, allium, medicinal value, degree of hydration, rat eyelens, nutrients absorption, drug equivalents.Garlic (Alfium sativum L) is an important and commercial bulbous crop that is popularly available both at immature and mature stages, but consumed to a limited extent due to reserved and unreserved preferences of the population. Garlic possesses higher nutritive value than other bulbous crops and rich source of carbohydrates, proteins and ascorbic acid (1). Critical appraisal of antioxidant and lipid oxidation of foods reviewed recently showed antioxidant capacity of 232 to garlic (2). Therapeutic properties of garlic have been recognized in processing of garlic capsules, tablets and other formulations related to human health (3). it has been also valued since long for its characteristic pungency, flavour and wide ranging medicinal properties due to accumulation of high concentration of different metabolites that constitute the basis for drug equivalents (3-5). Aqueous garlic extract contains the water soluble thiosulfinates and have strong antimicrobial activity (6, 7). Studies on phenols, structural carbohydrates and levels of peroxidase and acid phosphatase were also carried out during garlic bulb development (8). The

Preventive Effects and Mechanisms of Garlic on Dyslipidemia and Gut Microbiome Dysbiosis

“…It is reported that L -Glutamate supplementation decreased HFD-deepened crypt depth, and enhanced the cell maturing rate and the secretory function of epithelial cells [40]. On the other hand, excessive consumption of garlic could result in the loss of intestinal epithelial cells [41], leading to the inhibition of intestinal absorption of glutamic acid, sucrose, and glucose [42], which might be the reason why garlic shortens the height of villi in a normal diet.…”

Stability and extraction of bioactive sulfur compounds from Allium genus processed by traditional and innovative technologies

“…To date, only a few bioactive OSCs have been extracted from Allium sp. by conventional procedures, mainly for analytical purposes and/or for the determination of biological activities (Arnault et al, 2003;Bocchini et al, 2001;Bose and Laha, 2013;Cavallito and Bailey, 1944;Gîtin et al, 2014;Han et al, 1995;Li et al, 2017;Mansor et al, 2016;Sekar et al, 2015;Songsungkan and Chanthai, 2014;Sood et al, 2003;Ueda et al, 1994). For instance, Ueda et al (1994) extracted trans-(+)-S-propenyl-L-cysteine sulfoxide (PeCSO), γ-glutamyl-PeCSO, and cycloalliin from onion.…”

Histological Evaluation of the Jejunum and Ileum of Rats after Administration of High Dose Garlic Aqueous Extract

“…Also Sood et al (14) reported alterations of brush border membrane, thinning and sloughing off of villous structures and vacuolization in jejunum of rats that were treated with garlic.…”

“…(2) However, excessive consumption of garlic could result in gastric mucosal erosion, reddening of the mucosa, and loss of intestinal epithelial cells. (3) Studies by Sood et al (14) showed that garlic intake led to inhibition of intestinal absorption of glutamic acid, sucrose and glucose. This research was aimed at studying the implications of excessive consumption of garlic on the histochemistry and functions of the small intestine.…”