Effect of Garlic (Allium sativum) on Heavy Metal (Nickel II and ChromiumVI) Induced Alteration of Serum Lipid Profile in Male Albino Rats

Gupta, Ajay; Das, Swastika; Dhundasi, Salim A; Das, Kusal K.

doi:10.3390/ijerph5030147

Cited by 16 publications

(7 citation statements)

References 28 publications

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“…In addition, the low hemoglobin concentration in this study may be as a result of a decrease in the succinyl and glycine pools, as well as the key enzymes such as, ALAD (Aminolevulinic Acid Dehydratase) that are required in the hem biosynthesis [43]. The leucopenia after nickel treatment may be attributed to the inhibition of white blood cell maturation, their release from tissue reservoir or occurrence of leucopoenia in an organism as a response to a stress caused by toxic compounds associated with allergic reaction [27].…”

Section: Discussionmentioning

confidence: 94%

Effect of Silymarin Extracted From Silybum Marianum on Nickel Hematotoxicity and Nephrotoxicity in Male Albino Wistar Rats

Bouhalit

Kechrid

Elfeki

2017

Int J Pharm Pharm Sci

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Objective: The objective of this study was to investigate the effect of silymarin extract from Silybum marianum against nickel-induced alterations in haematological indices, kidney dysfunction and renal antioxidant defence system. Methods:Male albino Wistar rats were divided into four groups seven each. Control, silymarin, nickel and nickel plus silymarin. Silymarin was administrated orally (100 mg/kg b. wt) and nickel as nickel sulfate (NiSO4 6H2 Results:The treatment with nickel led to a significant decrease in body weight with an increase in both absolute and relative kidney weights and a significant increase in renal markers, which confirmed by histopathological alteration. A microcytic anemia was also observed, which was manifested by a reduction of red blood cells count (RBC), hemoglobin (Hb) concentration, platelet counts (Plt), hematocrit and white blood cells counts (WBC). The level of lipid peroxidation was increased. Whereas, GSH concentration and enzymatic antioxidants SOD, GSH-Px and CAT activities were decreased. The co-treatment with methanolic extract of milk thistle attenuated the variation in the hematological and renal markers, decreasing renal lipid peroxidation (p<0.05) with a concomitant increasing reduced glutathione content (p<0.01) and restoring the antioxidant enzymes (SOD, CAT, GSH-Px) in kidney, as well as an improvement in histological changes compared to those previously noticed in nickel group. 0) was given intraperitoneally (20 mg/kg b. wt) at alternative days. The experiment continued for three consecutive weeks. Body weight was recorded regularly. After overnight fasting, animals were killed and serum creatinine, serum urea, serum uric acid, hematological parameters and renal antioxidant markers were determined. Conclusion:To conclude, these findings demonstrated that silymarin extract effectively improved heamatotoxicity and nephrotoxicity caused by nickel.

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Section: Discussionmentioning

confidence: 94%

Effect of Silymarin Extracted From Silybum Marianum on Nickel Hematotoxicity and Nephrotoxicity in Male Albino Wistar Rats

Bouhalit

Kechrid

Elfeki

2017

Int J Pharm Pharm Sci

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“…Owing to the use of harmful chemicals in fish farming, which threatened human health, several studies are attempting the introduction of vegetable supplements in fish feeds. Garlic, which has been widely used in traditional medicine since ancient times, is one such example of a vegetable plant supplement (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

“…Garlic, used as a feed additive in fish breeding, is also used to raise meat quality. Garlic reportedly protects fish from heavy metal effects and causes changes in the lipid profile (2). Many studies have investigated the effects of garlic on fish but have mainly focused upon the influence of garlic on blood parameters and immunity of fish; however, research regarding the effects on fatty acids content in and body composition of fish remain limited.…”

Section: Introductionmentioning

confidence: 99%

Effect of garlic (Allium sativum) - supplemented diet on growth performance, body composition and fatty acid profile of rainbow trout (Oncorhynchus mykiss)

Öz

Dikel

2022

Cell Mol Biol (Noisy-le-grand)

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In this study, rainbow trout were fed for a total of 90 days with different feed mixes containing 0.00%, 1.00%, 1.50% and 2.00% garlic (Allium sativum). The effect of garlic on the growth performance, body composition and fatty acid profile of rainbow trout was researched. The starting weight of fish in the experimental group was approximately 64.12±0.29 gr, which increased to 234.12±3.54gr, 246.31±4.41gr, 258.74±4.42gr, and 268.79±4.79gr, while the difference in growth between the groups was observed to be statistically significant (p<0.05). At the end of the feeding period, the specific growth rate (SGR), the economic conversion ratio (ECR), the feed conversion ratio (FCR), the economic profit index (EPI) and the protein efficiency ratio (PER) were checked. In this study, the nutritional composition and fatty acid profiles of fish after 90 days of feeding were examined. As a result of this study, the supplementation of garlic to the diet given to rainbow trout caused an increase in their protein ratio and a decrease in their moisture content and fat ratio. Additionally, it led to a decrease in fatty acid and monounsaturated fatty acid levels and an increase in polyunsaturated fatty acids.

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“…As a food additive in fish, garlic has a food calling effect and improves flesh quality. Garlic may also prevent heavy metal-induced alterations in the lipid profile (Gupta et al 2008). These effects of garlic are attributed to the presence of various organosulfur compounds, including allicin (Augusti et al 1974).…”

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confidence: 99%

Review of the Application of Garlic, Allium sativum, in Aquaculture

Lee¹,

Gao²

2012

J World Aquaculture Soc

108

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The extensive use of antibiotics and various chemical compounds has resulted in drug residue and resistant pathogens in treated fish. Drug residue not only pollutes the environment, but also threatens human consumers. In contrast, garlic as a well‐known natural antibiotic that causes no environmental or physical side effects has shown to be effective for the treatment of many diseases in humans and animals owing to its antimicrobial, antioxidant, and antihypertensive properties. In aquacultural operations, garlic with dose optimization is strongly recommended. This review focuses on the application of garlic in various fish diseases treatments and the prospects of using garlic preparations in aquaculture.

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Effect of Garlic (Allium sativum) on Heavy Metal (Nickel II and ChromiumVI) Induced Alteration of Serum Lipid Profile in Male Albino Rats

Cited by 16 publications

References 28 publications

Effect of Silymarin Extracted From Silybum Marianum on Nickel Hematotoxicity and Nephrotoxicity in Male Albino Wistar Rats

Effect of Silymarin Extracted From Silybum Marianum on Nickel Hematotoxicity and Nephrotoxicity in Male Albino Wistar Rats

Effect of garlic (Allium sativum) - supplemented diet on growth performance, body composition and fatty acid profile of rainbow trout (Oncorhynchus mykiss)

Review of the Application of Garlic, Allium sativum, in Aquaculture

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