Effect of Garcinia kola biflavonoid fractions on some biochemical parameters of P407-induced hyperlipidemic albino rats: a phytopreventive and phytotherapeutic studies

Ameh, D. A.; Adejor, Ene Blessing; James, Dorcas Bolanle

doi:10.1007/s00580-013-1868-4

Cited by 5 publications

(4 citation statements)

References 20 publications

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“…In the hyperlipidemia model, the decreased levels of ALB may be closely related to the decline of liver function resulting in decreased liver production. 56 The lower level of ALB could increase the risk of cardiovascular disease in the elderly and affect their prognosis. 57 ALB has a heart-shaped tertiary structure consisting of three structurally homologous helical structural domains (I–III), each of which comprises two subdomains (A and B).…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology combined with metabolomics and lipidomics to reveal the hypolipidemic mechanism ofAlismatis rhizomain hyperlipidemic mice

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Network pharmacology combined with metabolomics and lipidomics to reveal the hypolipidemic mechanism ofAlismatis rhizomain hyperlipidemic mice

et al. 2022

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“…The rats were randomly divided into 2 major groups (Prophylactic and Therapeutic); with a total of 10 sub-groups comprising of 6 rats each as previously described by Ameh et al [16]. Briefly, sub-groups 3-6 were administered atorvastatin, root bark, stem bark and seed biflavonoid fractions respectively for 19 days and on the 19 th day, injected with P407 (500 mg/kg b. wt) and sacrificed 48 h after (Prophylactic study) while subgroups 7-10 were administered P407 (500 mg/kg b. wt) at 48 h interval for 21 days; treatment commenced 2 h after induction (Therapeutic Study).…”

Section: Animal Groupingmentioning

confidence: 99%

Effects of Garcinia kola biflavonoid fractions on serum lipid profile and kidney function parameters in hyperlipidemic rats

et al. 2016

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Background: Garcinia kola is used in traditional medicine in various parts of Africa including Nigeria for the amelioration of hypertension, cough, diabetes, sickle cell anemia, bacterial and fungal infections amongst others. The prophylactic and therapeutic efficacy of Garcinia kola biflavonoid fractions (GKBF); root bark (RBBF), stem bark (SBBF) and seed (SBF)) on the lipid profile and kidney function of Poloxamer 407 (P407) induced hyperlipidemic rats were determined.

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“…However, Ameh et al, [ 23 ] found no effect on ALT except on AST, while Johnston et al, [ 24 ] reported that P407 does not cause hepatic injury or damage.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effect of Camel Milk on Poloxamer 407 Induced Hyperlipidaemic Wistar Rats

Zuberu

Saleh

Alhassan

et al. 2017

Open Access Maced J Med Sci

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AIM:To investigate the effect of oral administration of camel milk on liver enzymes, total proteins and histology of poloxamer 407 induced hyperlipidaemic wistar rats.MATERIAL AND METHODS:Thirty male wistar rats weighing between 150-200 g were randomly assigned into six groups of five each; group I: administered distilled water, group II: induced with P407, group III: induced with P407 and treated with atorvastatin (20 mg/kg) and groups IV, V and VI: induced with P407 and treated with camel milk 250 mg/kg, 500 mg/kg and 1000 mg/kg respectively. After three weeks, blood samples and liver tissues were collected for the determination of alkaline phospatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein, albumin, globulin, albumin/globulin ratio and histological studies respectively.RESULTS:All camel milk treated groups showed significant (p < 0.05) decrease in ALT and AST. Camel milk treated groups; 250 mg/kg and 1000mg/kg showed significant (p < 0.05) decrease in total protein, globulin with all camel milk treated groups having significant (p < 0.05) increase in A/G ratio. Histological examination of liver tissues showed that camel milk at a dose of 250 mg/kg had slight adipocytes infiltration.CONCLUSION:The results of our findings highlight the hepatoprotective effect of camel milk in poloxamer 407 induced hyperlipidaemic wistar rats.

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Effect of Garcinia kola biflavonoid fractions on some biochemical parameters of P407-induced hyperlipidemic albino rats: a phytopreventive and phytotherapeutic studies

Cited by 5 publications

References 20 publications

Network pharmacology combined with metabolomics and lipidomics to reveal the hypolipidemic mechanism ofAlismatis rhizomain hyperlipidemic mice

Network pharmacology combined with metabolomics and lipidomics to reveal the hypolipidemic mechanism ofAlismatis rhizomain hyperlipidemic mice

Effects of Garcinia kola biflavonoid fractions on serum lipid profile and kidney function parameters in hyperlipidemic rats

Hepatoprotective Effect of Camel Milk on Poloxamer 407 Induced Hyperlipidaemic Wistar Rats

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