Effect of gamma interferon on lung function of mustard gas exposed patients, after 15 years

Ghanei, Mostafa; Panahi, Yunes; Mojtahedzadeh, Mojtaba; Khalili, Ali Reza Hosseini; Aslani, Jafar

doi:10.1016/j.pupt.2005.07.003

Cited by 28 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…64 A 6-month treatment with gamma interferon, an anti-inflammatory effect via down-regulation transforming growth factor-b gene expression, is associated with an improvement in the lung function in SM-exposed patients with bronchiolitis. 65 In summary, the enhanced activity of antioxidant enzymes and depleted glutathione content is indicative of oxidative tissue injury in lung of SM-induced chronic bronchitis patients. The increased malondialdehyde level is indicative of the damage that occurs in membranes of tissues as a result of free radical generation.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of plasma, erythrocytes, and brochoalveolar lavage fluid antioxidant defense system in sulfur mustard-injured patients

Jafari

Ghanei

2010

Clinical Toxicology

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Evaluation of plasma, erythrocytes, and brochoalveolar lavage fluid antioxidant defense system in sulfur mustard-injured patients

Jafari

Ghanei

2010

Clinical Toxicology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although spirometric parameters showed an increasing trend from baseline to the end of trial, these changes were not of statistical significance, apart from FEV 1 that had a borderline significant elevation. Findings from a previous investigation implied that treatment with IFNg improved spirometric function (Ghanei et al, 2006). In the study by Ghanei et al (2006), treatment with 200 mg IFNg (three times per week) plus 7.5 mg of prednisolone (once a day) for 6 months was associated with significant elevation of both FEV 1 and FVC compared to the control group.…”

Section: Discussionmentioning

confidence: 73%

“…Findings from a previous investigation implied that treatment with IFNg improved spirometric function (Ghanei et al, 2006). In the study by Ghanei et al (2006), treatment with 200 mg IFNg (three times per week) plus 7.5 mg of prednisolone (once a day) for 6 months was associated with significant elevation of both FEV 1 and FVC compared to the control group. Lack of significant changes in spirometric parameters in the present study could be due to the smaller population size and not administering an oral corticosteroid as adjunctive therapy.…”

Section: Discussionmentioning

confidence: 73%

Effect of recombinant human IFNγ in the treatment of chronic pulmonary complications due to sulfur mustard intoxication

Panahi¹,

Ghanei²,

Vahedi³

et al. 2013

Journal of Immunotoxicology

Self Cite

View full text Add to dashboard Cite

Pulmonary problems are among the most common chronic complications of sulfur mustard (SM) intoxication and adversely affect patients' quality-of-life. The present trial investigated the impact of immunotherapy with interferon (IFN)-g on quality-of-life, respiratory symptoms, and circulating immunologic and oxidative parameters in patients suffering from chronic SMinduced complications. Patients (n ¼ 15) were administered IFNg (100 mg) every other day for a period of 6 months. Assessment of quality-of-life [using St. George respiratory Questionnaire (SGRQ) and COPD Assessment Test (CAT) indices], the severity and frequency of respiratory symptoms, and serum levels of immunologic [including interleukin (IL)-2, IL-4, IL-6, IL-10, IFNg, calcitonin gene related peptide (CGRP), matrix metallopeptidase (MMP)-9, and tumor necrosis factor (TNF)-a], oxidative stress [malondialdehyde (MDA) as well as total and reduced glutathione, and catalase and superoxide dismutase (SOD) activity], and fibrogenic [transforming growth factor (TGF)-b] parameters were performed at baseline and at trial end. The results indicated that IFNg therapy is associated with improvements in SGRQ (p50.001) and CAT (p50.001) scores, decreased severity of cough (p ¼ 0.001), dyspnea (p50.001), and morning dyspnea (p50.001), reduced frequency of sputum production (p50.001) and hemoptysis (p50.001), and elevated FEV 1 (p ¼ 0.065). Serum levels of IL-4 (p50.001), IL-6 (p50.001), IL-10 (p50.001), CGRP (p50.001), MMP-9 (p ¼ 0.001), TNFa (p50.001), TGFb (p50.001) and MDA (p ¼ 0.001) were decreased while those of IL-2 (p50.001), IFNg (p50.001), and both total (p ¼ 0.005) and reduced glutathione (p ¼ 0.061) increased by the end of the trial. It was concluded that IFNg has favorable effects on the quality-of-life and alleviates respiratory symptoms in patients suffering from chronic SM-induced pulmonary complications. A modulation of cytokines and oxidative stress appears responsible for the clinical efficacy of IFNg.

show abstract

“…A recent study shows that the level of transforming growth factor- β is significantly increased in lavage fluid of patients with sulfur mustard-exposure, compared with veterans not exposed to sulfur mustard [52]. A 6-month treatment with gamma interferon, an anti-inflammatory effect via down-regulation transforming growth factor- β gene expression, is associated with an improvement in the lung function in sulfur mustard exposed patients with bronchiolitis [53]. However, recent studies showed that the serum levels of inflammatory cytokines such as IL-8, IL-6 [54], IL-1alpha, IL-1beta, and TNF-alpha, except for IL-1Ra and MMP-9 [55], decreased in SM-exposed subjects.…”

Section: Discussionmentioning

confidence: 99%

The Role of Fas-FasL Signaling Pathway in Induction of Apoptosis in Patients with Sulfur Mustard-Induced Chronic Bronchiolitis

Pirzad

Jafari

Tavana

et al. 2010

Journal of Toxicology

Self Cite

View full text Add to dashboard Cite

Sulfur mustard (SM) is an alkylating agent that induces apoptosis and necrosis in cells. Fas-Fas ligand (FasL) interaction could induce apoptosis as well. In this study, it was hypothesized that apoptosis might play an important role in the pathogenesis of SM-induced lung injury via Fas-FasL signaling pathway. In a case-control study, Fas and FasL levels, caspase-3 activity and percent of apoptotic cells were measured in bronchoalveolar lavage (BAL) fluid of patients 20 years after exposure to sulfur mustard and compared with the control group. Results show that Fas and FasL levels were significantly higher in BAL fluid cells in patients group compared with the control (P = .001). No significant differences were observed between mild and moderate-severe groups. BAL fluid cells caspase-3 activity was not significantly different among the mild, moderate-severe, and control groups. The data suggest that Fas-FasL-induced apoptosis was impaired in BAL fluid cells of SM-exposed patients which might be one of the initiators of pathogenesis in SM-induced lung injury in these patients.

show abstract

Effect of gamma interferon on lung function of mustard gas exposed patients, after 15 years

Cited by 28 publications

References 29 publications

Evaluation of plasma, erythrocytes, and brochoalveolar lavage fluid antioxidant defense system in sulfur mustard-injured patients

Evaluation of plasma, erythrocytes, and brochoalveolar lavage fluid antioxidant defense system in sulfur mustard-injured patients

Effect of recombinant human IFNγ in the treatment of chronic pulmonary complications due to sulfur mustard intoxication

The Role of Fas-FasL Signaling Pathway in Induction of Apoptosis in Patients with Sulfur Mustard-Induced Chronic Bronchiolitis

Contact Info

Product

Resources

About