Effect of free or protein‐associated soy isoflavones on the antioxidant status in rats

Barbosa, Ana Cristina Lopes; Lajolo, Franco Maria; Genovese, Maria Inês

doi:10.1002/jsfa.4242

Cited by 28 publications

(20 citation statements)

References 46 publications

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“…Interestingly, soy protein supplementation decreased GSH in the present study indicating reduced antioxidant activity. In contrast, soy isoflavones were shown to increase the activities of antioxidant enzymes in humans [34], however the form of isoflavone administered played a role in the enhancement of antioxidant status. In fact, free soy isoflavones were shown to be more effective at increasing antioxidant status in rats when compared to protein-associated isoflavones and soy protein extracts [34].…”

Section: Discussionmentioning

confidence: 91%

Whey Protein, but Not Soy Protein, Supplementation Alleviates Exerciseinduced Lipid Peroxidation in Female Endurance Athletes

Tara¹,

Park²,

Mathison³

et al. 2013

TONUTRJ

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Purpose: The objective of this study was to assess the protective effects of whey and soy protein supplementation on inflammatory response, oxidative damage and body composition in active female endurance athletes. Methods: Healthy female endurance athletes (18-25 y; n = 18) running at least one hour per day, five days per week were randomly assigned to consume 40 g whey or soy protein daily, in a 6-wk double-blind study. Blood samples were obtained following completion of a one hour run at baseline and wk 6, and analyzed for inflammatory and oxidative biomarkers. DXA scans were completed to determine body composition. Results: Whey protein intervention decreased (P> 0.05) plasma TBARS concentrations, indicating suppressed lipid peroxidation. Supplementation with soy protein had no effect on markers of oxidative damage and inflammation, but decreased (P> 0.05) reduced glutathione indicating a reduction in antioxidant activity. Protein supplementation had no significant effect on body composition. Conclusions: Supplementation with whey protein decreased lipid peroxidation in in female endurance athletes suggesting a potential antioxidative action, while soy protein did not improve biomarkers of oxidative damage and inflammation.

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Section: Discussionmentioning

confidence: 91%

Whey Protein, but Not Soy Protein, Supplementation Alleviates Exerciseinduced Lipid Peroxidation in Female Endurance Athletes

Tara¹,

Park²,

Mathison³

et al. 2013

TONUTRJ

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show abstract

“…Soy based supplements are reported to have antioxidant effects in animals [40] and humans [41]. Furthermore, a clinical study in pre- and post-menopausal Korean women reported soy intake was inversely correlated with oxidative stress (TBARS) [42].…”

Section: Discussionmentioning

confidence: 99%

Does Glycine max leaves or Garcinia Cambogiapromote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial

Kim

Jeon

Park

et al. 2011

Nutr J

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BackgroundNatural food supplements with high flavonoid content are often claimed to promote weight-loss and lower plasma cholesterol in animal studies, but human studies have been more equivocal. The aim of this study was firstly to determine the effectiveness of natural food supplements containing Glycine max leaves extract (EGML) or Garcinia cambogia extract (GCE) to promote weight-loss and lower plasma cholesterol. Secondly to examine whether these supplements have any beneficial effect on lipid, adipocytokine or antioxidant profiles.MethodsEighty-six overweight subjects (Male:Female = 46:40, age: 20~50 yr, BMI > 23 < 29) were randomly assigned to three groups and administered tablets containing EGML (2 g/day), GCE (2 g/day) or placebo (starch, 2 g/day) for 10 weeks. At baseline and after 10 weeks, body composition, plasma cholesterol and diet were assessed. Blood analysis was also conducted to examine plasma lipoproteins, triglycerides, adipocytokines and antioxidants.ResultsEGML and GCE supplementation failed to promote weight-loss or any clinically significant change in %body fat. The EGML group had lower total cholesterol after 10 weeks compared to the placebo group (p < 0.05). EGML and GCE had no effect on triglycerides, non-HDL-C, adipocytokines or antioxidants when compared to placebo supplementation. However, HDL-C was higher in the EGML group (p < 0.001) after 10 weeks compared to the placebo group.ConclusionsTen weeks of EGML or GCE supplementation did not promote weight-loss or lower total cholesterol in overweight individuals consuming their habitual diet. Although, EGML did increase plasma HDL-C levels which is associated with a lower risk of atherosclerosis.

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“…As a result, isoflavones can be used to block estrogen from binding to its receptors on cell membrane, with several favorable health benefits such as the reduction of the risk of estrogen-dependent cancers including breast, ovarian, and endometrial cancers [3][4][5]. In addition to their estrogenic properties, isoflavones were reported to have antioxidant properties by enhancing the activities of catalase, superoxide dismutase and glutathione reductase [6]. Again, due to their resemblance to estrogen-like molecules, naturally occurring isoflavones are also thought to play an important role in the prevention of osteoporosis [7].…”

Section: Introductionmentioning

confidence: 99%

Isoflavone aglycons-sulfobutyl ether-β-cyclodextrin inclusion complexes: in solution and solid state studies

Stancanelli

Venuti

Arigò

et al. 2015

J Incl Phenom Macrocycl Chem

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The effect of a polyanionic variably substituted sulfobutyl ether-b-cyclodextrin (SBE-b-CyD), complexation on the UV absorption of genistein (Gen) and daidzein (Dai) was studied in pure water. A phase solubility study was performed, according to the method reported by Higuchi and Connors, to evaluate the changes of isoflavones in the complexation state and type-A L solubility diagrams for both isoflavones were obtained suggesting that they form complexes with 1:1 molar ratio. These results were confirmed by Job's plot method. Complexation strongly increases the water solubility of isoflavones. The in vitro dissolution of isoflavones entrapped into SBE-b-CyD significantly surpassed that of the free isoflavones (over 90 % of the loaded Gen and Dai dissolved in 15 and 30 min, respectively). Finally, 1:1 molar ratio solid complexes were prepared by the kneading method and characterized in solid state by FTIR-ATR spectroscopy, with particular regard to O-H and C=O stretching vibrations, achieving structural information on the modifications induced by complexation on the H-bond scheme, also by applying band decomposition and curve-fit.

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Effect of free or protein‐associated soy isoflavones on the antioxidant status in rats

Cited by 28 publications

References 46 publications

Whey Protein, but Not Soy Protein, Supplementation Alleviates Exerciseinduced Lipid Peroxidation in Female Endurance Athletes

Whey Protein, but Not Soy Protein, Supplementation Alleviates Exerciseinduced Lipid Peroxidation in Female Endurance Athletes

Does Glycine max leaves or Garcinia Cambogiapromote weight-loss or lower plasma cholesterol in overweight individuals: a randomized control trial

Isoflavone aglycons-sulfobutyl ether-β-cyclodextrin inclusion complexes: in solution and solid state studies

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