Effect of food products on endogenous generation of <i>n</i>−nitrosamines in rats

Atanasova-Goranova, V. K.; Dimova, P; Pevicharova, Galina

doi:10.1079/bjn19970151

Cited by 40 publications

(19 citation statements)

References 5 publications

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“…Furthermore, Aronia juice intake was shown to inhibit the endogenous generation of N-nitrosamines in rats treated with aminopyrin plus sodium nitrite. In consequence, histopathological changes observed in livers of rats fed with nitrosamine precursors were prevented by co-treatment with Aronia juice [90].…”

Section: Antimutagenic Effectsmentioning

confidence: 87%

“…Phenolic compounds isolated from berries of Aronia melanocarpa also exert an antimutagenic activity as documented in [89], [90]. Anthocyanins isolated from Aronia markedly inhibited the mutagenic activity of benzo[a]pyrene and 2-aminofluorene in the Ames test as well as in the sister chromatid exchange assay with cultured human lymphocytes [89].…”

Section: Antimutagenic Effectsmentioning

confidence: 99%

See 1 more Smart Citation

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

Kulling¹,

Rawel²

2008

Planta Med

450

458

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Botanical Background and Cultivation ! Aronia berries originate from the eastern parts of North America and East Canada [1], [2], [3]. Their migration to Europe occurred around 1900 via Germany to Russia and back. Around 1946 the plant was established as a cultivar in the former Soviet Union. More recently it is cultivated also in East European countries and Germany (Oberlausitz) [1], [2]. The genus name Aronia has been replacing the common name, chokeberry. Two species can be distinguished: Aronia melanocarpa [Michx.] Elliot (black chokeberry, Aronia noir) and Aronia arbutifolia [L.] Elliot (red chokeberry, Aronia rouge) [3]. A third entity is intermediate and has variously been considered a species (A. prunifolia), a variety of each of the other two, or a hybrid [3]. The other common names for Aronia besides chokeberries include black apple berry and rowanberries (Sorbus aucuparia L.), whereby in the latter case the hybrids of rowanberry with Aronia are likely to be addressed [4], [5], [6]. Aronia is a member of the Rosaceae family, and the cultivars used for fruit production are from the species Aronia melanocarpa [6], [7], [8], [9]. Cultivars have been bred for larger edible fruits and ornamental value. The plants have no known pest problems [10]. Some cultivars are bred of true black chokeberry (Aronia melanocarpa) and some are hybrid cultivars (e. g., Aronia x Sorbus) [5], [11]. The more important cultivars include "Nero" (Czechia), "Rubina" (crossing from Russian and Finnish plants), "Viking" (Finland), "Kurkumäcki" (Finland), "Hugin" (Sweden), "Fertödi" (Hungary) and "Aron" (Denmark) [2]. "Viking" and "Nero" are cultivars that are commonly available in North American plant catalogues [7]. The Aronia shrubs can grow to a height of 2-3 m, which produce in May to June umbels of some 30 small white flowers, ripening to bright red (red chokeberry) or to purplish black berries (black chokeberry; Ø 6-13 mm, 0.5-2 g) [1], [2], [8], [12]. Harvest is performed mechanically between August and September. Five to twelve tons per hectare can be expected in about five years, once plants have matured [7], [8]. The effect of fertiliser rate on fruit quality parameters in the black chokeberry showed that an increased fertiliser application results in increased growth and higher yield whereas pigment content and total acidity decreased. Maximum production of anthocyanins per plant was obtained with a medium high fertiliser rate (50 kg N/ha, 44 kg P/ha, 100 kg K/ ha) [13]. The content of undesirable brown compounds and that of desirable anthocyanins is also dependent on maturation as documented in [11]. A recent study illustrates that applied fertilization may exert a differential influence on the chemical composition of Aronia fruits especially with regard to sugar content and the quantity

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Section: Antimutagenic Effectsmentioning

confidence: 87%

Section: Antimutagenic Effectsmentioning

confidence: 99%

Chokeberry(Aronia melanocarpa)– A Review on the Characteristic Components and Potential Health Effects

Kulling¹,

Rawel²

2008

Planta Med

450

458

View full text Add to dashboard Cite

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“…Garlic derivatives have shown protective effects against genotoxic materials by changing their metabolic pathway. Garlic has anticancer effects through inhibiting the production and bioactivity of nitrosamines (Atanasova‐Goranova, Dimova, & Pevicharova, ). Nitrosamines play important roles in causing and increasing the risk of cancer (Gankhuyag, Lee, & Cho, ).…”

Section: A Sativummentioning

confidence: 99%

Allium vegetables for possible future of cancer treatment

Asemani

Zamani

Bayat

et al. 2019

Phytotherapy Research

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Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerous diseases. The phytochemical analysis of various Allium genus members showed that, to date, 16 species have proved potential anticancer properties due to the accumulation of various sulfur and organic compounds like S‐allyl mercaptocysteine, quercetin, flavonoids, and ajoene. These compounds with various mechanisms such as hindering cell cycle, inhibiting signaling pathways, inducing apoptosis, and antioxidant activity interfere with diverse stages of formation, growth, differentiation, and metastasis of cancer cells. Similar to garlic and onion, other species have exhibited anticancer activities, so that active natural molecules extracted from them might serve as possible anticancer agents. Therefore, evaluating the main ingredients and studying their anticancer mechanisms are of great importance. In this review, we aim to summarize the available data on anticancer mechanisms of 16 species of Allium genus and their major compounds to assist further researches on the treatment and prevention of cancers.

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“…[7][8][9] A number of different colonic bacteria are able to catalyze formation of N-nitroso compounds, 10,11 although the significance of the healthy colon as a site for nitrosation is unclear. 12 Nitrosation reactions are inhibited by vitamin C, as well as vitamin E and some carotenoids, 7,[13][14][15] resulting in lower production of N-nitroso compounds in the stomach. It is unclear, however, whether these compounds are available to inhibit nitrosation in the colon.…”

mentioning

confidence: 99%