Effect of folic acid and vitamin B12 administration on phenytoin induced toxicity in rats

Ekaidem, Itemobong S.; Akpanabiatu, M. I.; Uboh, F. E.; Eka, O.U.

doi:10.1007/bf02913310

Cited by 7 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed restorations in the activity of previous enzymes after folic acid incubation are in agreement with previous studies (Al-Bazii, 2009). Similarly (Ekaidem et al, 2007). Reported that serum ALT and AST activities were return to normal activity by folic acid therapy.…”

Section: Hypoalbuminemiamentioning

confidence: 99%

Protective Effect of Folic Acid on Oxidative Stress Induced by Methionine Overload in Male Mice

Rahi¹,

albazi²,

Aljarah³

et al. 2021

PLANT ARCHIVES

View full text Add to dashboard Cite

Methionine is a basic sulfur that contains important amino acid and is necessary for many vital activities necessary in the body, Methionine is considered a preventive agent for many liver damages, But in the case of excessive iron administration, it has a negative effect. One hundred and fifty (150) mice model selected for present study is Albeno pulp-c and their ages between (12-16) a week, One hundred fifty (150) adult mice were randomly divided into 5 groups (thirty each group) and treated for six weeks. Group I animals were incubated orally tap water, serving as control, Group II animals were incubated orally L-methionine, Group III animals were incubated orally folic acid ,Group IV animals were incubated methionine plus folic acid, and after the end of the experiment, the following criteria were measured GSH, MDA, AST, ALP, ALT, albumin concentration and globulin concentration. methionine overload administration leads to a decrease in concentration of GSH in G2 and an increase in concentration of GSH in G3and G4, and an increase in concentration of MDA in G2 and decrease in concentration of MDA in G3 and G4, and a significant decrease in globulin concentration in G2 compared to G1 and non significant difference between G3,G4 and G1, Also, the albumin concentration in this experiment was found to have a significant increase in G3 compared to G1, and also there was a significant decrease in G2, and there was non significant difference between G4 and G1, a significant increase in activity of AST in G2 compared to G1 and a significant decrease in activity AST in G4 and G3, compared to G1, a significant increase in G2 in the ALT activity compared to G1, and a significant decrease in activity in G3 compared with G1 and there was non significant difference in activity ALT between G1 and G4, Also showed a significant increase in activity ALP in G2 compared to G1 and a significant decrease in activity ALP in G3 and non significant difference in activity ALP in G4 compared to G1, methionine overload may cause oxidative stress in most cells of the body resulting in the release of free radicals in the cells of the tissues.

show abstract

Section: Hypoalbuminemiamentioning

confidence: 99%

Protective Effect of Folic Acid on Oxidative Stress Induced by Methionine Overload in Male Mice

Rahi¹,

albazi²,

Aljarah³

et al. 2021

PLANT ARCHIVES

View full text Add to dashboard Cite

show abstract

“…received both of Vitamins B9 (50 mg/kg/day using intragastric tube) [15] and B12 (15 μg/kg intraperitoneal twice a week) [16], and the fifth, diabetic group received Vitamins D, B9, and B12 as previously described.…”

Section: Experimental Protocolmentioning

confidence: 99%

Efficacy of Cosupplementation Therapy With Vitamins B9, B12, and D on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats

JOUFI

Bana

Tewfik

et al. 2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: This study evaluated the effects of Vitamins D, B9, and B12 given individually or combined in ameliorating some biochemical parameters related to endothelial dysfunction in diabetic rats.Methods: A total of 50 Sprague-Dawley male rats were divided into five groups: Control, diabetic, diabetic received Vitamin D, diabetic received Vitamins B9 and B12, and diabetic received Vitamins B9, B12, and D. At the end of 6 weeks, the rats were sacrificed and a set of assays was carried out to determine: Fasting blood sugar (FBS), lipid profile, nitric oxide (NO), homocysteine (Hcy), malondialdehyde (MDA), and serum levels of Vitamins B9, B12, and D.Results: Diabetic rat received Vitamin D and diabetic rat received Vitamins B9 and B12 had a significant decline in the levels of FBS, lipid profile, and Hcy with reduced MDA (p<0.05) release but significant increase in NO level. On the same hand, diabetic rat received combined supplementation of Vitamins B9, B12, and D had more pronounced effect (p<0.00).Conclusion: Given these findings, the combined vitamins therapy had antiatherosclerotic effects by inhibiting lipid peroxidation and stimulating NO production, resulting in amelioration the endothelial dysfunction in diabetic rat.

show abstract

“…Vitamin supplementation is known to impart significant benefits in terms of disease prevention and treatments and has been widely accepted as a measure of control of micro-nutrient deficiencies Eka Idem, Akpanabiatu, Uboh, & Eka, (2007). The addition of vitamins to food upgrade the food value and prevent malnutrition and other noncommunicable diseases.…”

Section: Introductionmentioning

confidence: 99%

Effects of Red Banana Meal Supplemented With Vitamin on Rats Biochemical Indices

Iniubong Abasiodiong Thomas,

Nkoyo Isong,

M.I. Akpanabiatu

et al. 2023

njhe

View full text Add to dashboard Cite

This study aimed at comparing the effects of peeled and unpeeled red banana meal with vitamin C, B12 andB complex supplementation on some biochemical indices of different groups of Wistar rats. Forty eight (48)weanling albino Wistar rats weighing between 41 – 57 g were used. They were randomly selected into six(6) groups consisting of eight (8) rats. Coded as Unpeeled Red Banana with Vitamin (URWV), UnpeeledRed Banana without Vitamin (URWO), Peeled Red Banana with Vitamin (PRWV), Peeled Red Bananawithout Vitamin (PRWV), nutribom and normal rat pellet. They experimental animals were acclimatized for3days and animals were given food and water for 21days the left overs were recorded daily. At the end ofthe 21days feeding, animals were anesthetized using chloroform vapour, blood sample taken for biochemicalanalyses serum AST, ALT, ALP, lipid profile were assayed .The results of the study showed that serum ALTof rat fed with unpeeled red banana with vitamin (URWV) was 26.88 ± 2.65µl/L while rat fed with nutribom(control) was 26.75 ± 1.60 µl/L. The ALP of rats fed with URWV was 239.43 ± 35.25 µl/L which increasedsignificantly (P ? 0.05) when compared with control (184.11 ± 16.68 µl\L/). Total cholesterol increasedsignificantly in URWV 3.87 ± 0.13 µl/L (p ? 0.05) when compared with control 1.86 ± 0.17 µl/L, TG & HDLlevel were not significantly higher than the control in URWV, PRWV and PRWO. Total protein, albumin andglobulin in all the groups were not significantly different (p ? 0.05) when compared with nutribom thecontrol.

show abstract

Effect of folic acid and vitamin B12 administration on phenytoin induced toxicity in rats

Abstract: ABSTRACT

Cited by 7 publications

References 12 publications

Protective Effect of Folic Acid on Oxidative Stress Induced by Methionine Overload in Male Mice

Protective Effect of Folic Acid on Oxidative Stress Induced by Methionine Overload in Male Mice

Efficacy of Cosupplementation Therapy With Vitamins B9, B12, and D on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats

Effects of Red Banana Meal Supplemented With Vitamin on Rats Biochemical Indices

Contact Info

Product

Resources

About