Effect of fluoxetine on serotonin and dopamine concentration in microdialysis fluid from rat striatum

Perry, Kenneth W.; Fuller, Ray W.

doi:10.1016/0024-3205(92)90423-m

Cited by 210 publications

(116 citation statements)

References 17 publications

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“…The two SSRIs fluoxetine and sertraline robustly increased [5-HT] ex in PFC, consistent with a number of previous studies on brain regions such as striatum and hypothalamus (Dreshfield et al 1996;Perry and Fuller 1992;Sprouse et al 1996). However, while fluoxetine treatment resulted in a sustained elevation of [NE] ex and [DA] ex in PFC, consistent with previous reports in hypothalamus (Perry and Fuller 1997) (Thomas et al 1998).…”

Section: Discussionsupporting

confidence: 91%

“…Rats were anesthetized with chloral hydrate/pentobarbital (170 mg/kg and 36 mg/kg in 30% propylene glycol and 14% ethanol, respectively) on operation day to allow the implantation of dialysis probes. Loop style microdialysis probes were constructed and implanted in the rat prefrontal cortex two days prior to use according to a previously published method (Perry and Fuller 1992). Coordinates for the PFC were: A (anterior to bregma) 3.2 mm, L (lateral from the midsagittal suture) 0.8 mm, and V (ventral from the dura surface) 4 mm (Paxinos and Watson 1986).…”

Section: Animal Surgerymentioning

confidence: 99%

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Synergistic Effects of Olanzapine and Other Antipsychotic Agents in Combination with Fluoxetine on Norepinephrine and Dopamine Release in Rat Prefrontal Cortex

Zhang

Perry

Wong

et al. 2000

Neuropsychopharmacology

191

136

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Section: Discussionsupporting

confidence: 91%

Section: Animal Surgerymentioning

confidence: 99%

Synergistic Effects of Olanzapine and Other Antipsychotic Agents in Combination with Fluoxetine on Norepinephrine and Dopamine Release in Rat Prefrontal Cortex

Zhang

Perry

Wong

et al. 2000

Neuropsychopharmacology

191

136

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“…Fluoxetine rapidly increases extracellular 5-HT in a variety of brain areas including the hypothalamus [21,24,29,36]. Thus, acute effects of fluoxetine are consistent with 5-HT's ability to inhibit female rat sexual behavior [27,38].…”

Section: Discussionmentioning

confidence: 65%

Subchronic treatment with fluoxetine attenuates effects of acute fluoxetine on female rat sexual behavior

et al. 2008

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These experiments were designed to evaluate the hypothesis that fluoxetine-induced sexual dysfunction in female rats derived from disruption of neuroendocrine events that normally facilitate sexual behavior. If so, exogenous hormonal priming to ovariectomized rats should eliminate fluoxetine's effect. Ovariectomized rats were subchronically treated with 10 mg/kg fluoxetine or distilled/deionized water vehicle for 9 consecutive days. On the 8 th day of treatment, rats were primed with 10 μg estradiol benzoate followed 48 hr later with 500 μg progesterone. In a pretest for sexual behavior on the 10 th day, there was no difference between subchronic treatments. Sexual receptivity was again monitored 30 min after injection on the 10 th day (acute treatment) with distilled/deionized water, 10 mg/kg fluoxetine or 20 mg/kg fluoxetine. Thereafter, the female's behavior was monitored for 20 min in a male preference procedure. After the acute treatment in rats subchronically treated with water, fluoxetine (10 or 20 mg/kg) significantly reduced both lordosis frequency and quality and reduced (but not significantly) time spent with the male. In rats subchronically treated with fluoxetine, the lordosis-inhibiting effect of an acute injection with fluoxetine was significantly attenuated relative to that of the subchronically water-treated rats. In contrast to expectation, subchronic treatment with fluoxetine increased, rather than reduced, the relative time females spent near the male. Activity, as measured by center crossings, and grooming were also reduced by subchronic treatment with fluoxetine. KeywordsSSRI; sexual motivation; lordosis; subchronic IntroductionFluoxetine (Prozac®) is frequently prescribed for depression as well as for a variety of other disorders such as premenstrual dysphoria, anxiety, anorexia and bulemia which are more prevalent in females than in males [4,19,22,33]. A reported undesirable side effect of fluoxetine, as well as other selective serotonin reuptake inhibitors (SSRIs), is a high incidence of sexual dysfunction [8,15,28]. Although such sexual dysfunction occurs in both genders, more experimental emphasis has been placed on identifying the responsible mechanisms in males than in females [17]. Yet, as much as 32% of female patients may experience SSRI-*Corresponding author Department of Biology, Texas Woman's University, Denton, TX 76204, Phone: 940-898-2356, FAX: 940-898-2382.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. [32]. The mechanisms responsible for such drug-induced sexual dysfunction in females have been difficult to identify,...

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“…Increased DA release may also contribute to the cueing by fluoxetine and 5-HTP which leads to the enhanced preference for the morphine environment seen in the acute morphine treated rats (discussed above). Although a number of reports have shown that fluoxetine in the doses used in this study has no effect on DA levels in the accumbens (Clark et al 1996;Ichikawa and Meltzer 1995;Perry and Fuller 1992), one recent study found that similar doses of fluoxetine significantly increased DA levels in the frontal cortex (Gobert et al 1997). The frontal cortex is one area shown to be hypofunctional during opiate abstinence and withdrawal in human opiate addicts (Danos et al 1998;Gerra et al 1998;Krystal et al 1995) and it is possible that the treatments given in this study may be effective in changing preference by altering activity in this brain region.…”

Section: Discussionmentioning

confidence: 72%

Augmented Accumbal Serotonin Levels Decrease the Preference for a Morphine Associated Environment During Withdrawal

Harris

Aston‐Jones

2001

Neuropsychopharmacology

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Recent studies have found that acute morphine administration increases serotonin (5-HT) transmission within the nucleus accumbens and other forebrain regions. In contrast, 5-HT transmission is depressed during withdrawal from chronic morphine. We show that pharmacological agents that increase brain 5-HT levels In addition to gross neurological and somatic signs the abstinence syndrome associated with opiate dependence involves important subjective responses including anxiety, anhedonia, depression and drug craving (Jaffe 1990). The control and elimination of the subjective symptoms, which linger long after the physical symptoms of opiate withdrawal have dissipated, has been a major obstacle to the successful treatment of opiate dependence (Childress et al. 1994). Understanding the alterations in brain chemistry that occur during abstinence from opiate abuse may lead to improved treatments for these symptoms, and greater success in treating opiate addiction.Acute systemic administration of morphine enhances brain 5-HT synthesis (Garcia-Sevilla et al. 1980) and tryptophan hydroxylase activity (Boadle-Biber et al. 1987). Acute morphine also enhances the turnover and release of 5-HT and dopamine (DA) in widespread areas of the forebrain (Spampinato et al. 1985;Tao and Auerbach 1994). The effect of morphine on 5-HT release appears to be mediated by activation of dorsal raphe neurons (Spampinato et al. 1985;Tao and Auerbach 1994) and may reflect disinhibition caused by direct inhibition of GABA transmission. A similar mechanism has also been proposed for the excitatory effects of opiates on DA neurons in the ventral tegmental area (Bloom et al. 1972;Bonci and Williams 1997).Neurons in the nucleus accumbens have been shown to be critically involved in the reinforcing properties of opiates (Dworkin et al. 1988;Pettit et al. 1984;Zito et al. 1985). Although morphine administration enhances 5-HT and DA levels within the accumbens (Spampinato et al. 1985;Tao and Auerbach 1995;Wise et al. 1995) (Ettenberg et al. 1982;Gerrits and Van Ree 1996;Pettit et al. 1984) or morphine place preference in animals (Mackey and van der Kooy 1985; however, also see Bozarth and Wise 1981;Smith et al. 1985;Spyraki et al. 1983). On the other hand, chemical lesions of 5-HT terminals in the accumbens impair morphine self-administration without affecting responding for food or water (Smith et al. 1987), and also block the acquisition of morphine conditioned place preference (CPP) (Spyraki et al. 1988).Withdrawal from opiates decreases both dopamine and 5-HT transmission in the brain. A single dose of morphine induces measurable reductions in both 5-HT and DA levels at 24 hours post-injection (AntkiewiczMichaluk et al. 1995). Withdrawal from longer chronic opiate treatments produces profound decreases in both dopamine (Acquas et al. 1991;Pothos et al. 1991;Rossetti et al. 1992) and 5-HT transmission (Ahtee 1980;Tao et al. 1998). Reduced 5-HT levels have been linked to both depression (Maes and Meltzer 1995) and compulsive behavior (Dolberg et al. ...

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Effect of fluoxetine on serotonin and dopamine concentration in microdialysis fluid from rat striatum

Cited by 210 publications

References 17 publications

Synergistic Effects of Olanzapine and Other Antipsychotic Agents in Combination with Fluoxetine on Norepinephrine and Dopamine Release in Rat Prefrontal Cortex

Synergistic Effects of Olanzapine and Other Antipsychotic Agents in Combination with Fluoxetine on Norepinephrine and Dopamine Release in Rat Prefrontal Cortex

Subchronic treatment with fluoxetine attenuates effects of acute fluoxetine on female rat sexual behavior

Augmented Accumbal Serotonin Levels Decrease the Preference for a Morphine Associated Environment During Withdrawal

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