Effect of Fluoxetine on Intraocular Pressure in the Rabbit

Psychotropic Drugs and Ocular Side Effects

“…Apart from this, the symptomatic glaucoma case related with his drug is not reported but the experimental studies have shown that fluoxetine might cause a significant IOP increase both on animals and human beings. 51,62 In conclusion, a 66 year old male patient was started using fluoxamine for headache and ACG has developed. When the use of drug was stopped, the symptoms of high IOP disappeared.…”

“…Serotonin receptors functioning in eye are; 5-HT1A, 5-HT2A, 5-HT2C ve 5-HT7. 38,40,[51][52][53][54][55] All these receptors have a role in IOP dynamics and effect can be seen on IOP increase and development of glaucoma. With the effect of serotonin on pupil sphincter localized 5-HT7 receptor and as a result of activation of adenylate cyclase it causes an increase in c-AMP and muscle relaxation and rise passive mydriasis.…”

“…With the effect of serotonin on pupil sphincter localized 5-HT7 receptor and as a result of activation of adenylate cyclase it causes an increase in c-AMP and muscle relaxation and rise passive mydriasis. [38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53] It is shown that SSRIs such as sertraline, paroxetine, fluoxetine and citalopram specifically cause pupil dilation. 38,56,57 As long as the mydriatic effect of SSRIs does not cause a dramatical increase in IOP and the development of glaucoma, it does not cause a major visual impairment or problem.…”

“…Therefore, aqueous outflow is prevented and glaucoma attack develops with IOP increase. 38,51 Indeed, more and more evidence has risen for the fact that IOP is increased by SSRIs day by day. With this, most of these cases are not reported, stays asymptomatic or turns into an ACG.…”

“…With this, most of these cases are not reported, stays asymptomatic or turns into an ACG. 38,51 In the PubMed survey, 11 articles are stated reporting the glaucoma in relation with SSRI. While 6 of these are related with paroxetine, 2 are citalopram, one is escitalopram, one is Fluoexetine, one is Fluvoxamine, there is not case notified on sertraline.…”